Medullary gradient is mainly developed due to (1) \( \mathrm{NaCl} ...

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Medullary gradient is mainly developed due to
(1) \( \mathrm{NaCl} \) and urea
(2) \( \mathrm{NaCl} \) and glucose
(3) Glucose and urea
\[
\text { page no. - } 296
\]
\( \mathrm{P} \)
W
(4) Ammonia and glucose
The proximity between the Henle's loop and vasa recta, as well as the counter current in them help in maintaining an increasing osmolarity towards the inner medullary interstitium, i.e., from \( 300 \mathrm{mOsmolL}^{-1} \) in the cortex to about \( 1200 \mathrm{mOsmolL}^{-1} \) in the inner medulla. This gradient is mainly caused by \( \mathrm{NaCl} \) and urea. \( \mathrm{NaCl} \) is transported by the ascending limb of Henle's loop which is exchanged with the descending limb of vasa recta \( \mathrm{NaCl} \) is returned to the interstitium by the ascending portion of vasa recta. Similarly, small amounts of urea enter the thin segment of the ascending limb of Henle's loop which is transported back to the interstitium by the collecting tubule.
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