Nanopore Basecalling for Directed Evolution

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United States Simons Institute for the Theory of Computing
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Published on ● Video Link: https://www.youtube.com/watch?v=sdlM_EW2saA


Duration: 28:01
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Ian Holmes (UC Berkeley)
https://simons.berkeley.edu/talks/nanopore-basecalling-directed-evolution
Computational Challenges in Very Large-Scale 'Omics'

Directed evolution offers a way to measure "fitness" of large numbers of synthetic sequences in parallel. Nanopore and other long-read sequencing technologies have the potential to probe distant epistatic interactions in such datasets, as well as resolving other genomic questions of interest in cancer, evolution, and other area of biology. I will describe our group's work in basecalling, analysis, and visualization of nanopore sequencing data, with an emphasis on synthetic biology applications.



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Tags:
Simons Institute
theoretical computer science
UC Berkeley
Computer Science
Theory of Computation
Theory of Computing
Computational Challenges in Very Large-Scale 'Omics'
Ian Holmes