The Silver Mine Writhes gives you a good look at what poison damage can do to a health bar, in short it can empty it very quickly.
Make your way through the level using the filtration machines whenever possible. There is always poison rocks wherever there is poison, break the rocks and the poison will dissipate from that particular section.
When it comes to the Giant Centipede, he never stops moving. Get above him and drop attack. The only threat is is head. Stay behind him and he'll fall quick enough
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