Plague Inc: Evolved - Simian Flu Mega-Brutal Guide (2025 World Update)

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Published on June 15, 2025 3:00:18 PM ● Video Link: https://www.youtube.com/watch?v=CXThhkqxk1c

Game:

Plague Inc: Evolved (2015)

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Welcome to a new series of Plague Inc: Evolved mega-brutal guides, remastered for the 2025 World Update!

The Simian Flu is profoundly different than any other scenario we've played up to this point, and most players struggle on Mega Brutal. But it turns out, once you understand its mechanics, beating this becomes trivial and easily repeated.

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Evolution Order:
-Simian Neuro-Genesis
-Ape Colonies
Place first colony.
-Inter-Genus Dissemination 1
-Cognitive Shift
-Education
Always devolve Neuro-Enhancement if it mutates
Place second colony.
-Organized Travel
Send Apes (NOT COLONIES) on long trips through as many countries as possible.
-Place third colony.
-Drug Resistance 1
-Cold Resistance 1
Place fourth colony.
-Cold Resistance 2
-Drug Resistance 2
Place fifth colony.
If EVERY country in the world has a wild ape, evolve Hominidae Bridge
-Ape Rampage
-Primal Hunt
-Fomites 1
-Fomites 2
-Fomites 3
-Blood 1
-Blood 2
-Extreme Haemoaerosol
Attack GenSys labs wherever they appear. Do not move camps unless you have to.
-Photophobia
-Subconjunctival Bleed
-Subconjunctival Haemorrhage
-Blindness
-Headache
-Fever
-Coma
-Meningitis
-Weapon Creation
-Nausea
-Vomiting
-Diarrhea
-Dysentery
Evolve any cheap symptoms with infectivity. Mutation will carry you for the rest of the game.
Always save a few points to move camps if drones appear, or attack labs.
Use attacks in countries to force more infection.


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Plague Inc: Evolved copyright is owned by their respective owners which includes but is not limited to Ndemic Creations. I did not make the game (or assets) and do not claim to. I do claim recording the video and audio associated with this playthrough.

Music credit:

"Forger"
by Quarter Roll
Provided by Epidemic Sound (http://www.epidemicsound.com/)

#plagueinc #plagueincevolved #strategy

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