There are only three small keys and locked drawers in the castle. Unlike the village area, they can be taken at any order, as long as Leon has not entered the final area, which is the clock tower. So avoid going there until you have opened all the locked drawers. Alternatively, you can keep a separate save file just before you go to the clock tower.
Time Stamps:
First small key location: 0:17
Second small key location: 1:06
Third small key location: 1:56
Please note the game recordings were made after version 1.0005, if anything changes in future game updates, I will post any differences in the video description or make a separate video, depending on how much was changed.
At this time, Nick SPP has 11,160 views for Resident Evil 4 spread across 131 videos. The game makes up over 10 days of published video on his channel, roughly 22.68% of Resident Evil 4 content that Nick SPP has uploaded to YouTube.