Resident Evil 5 Professional S Rank challenge [Chapter 5-3] (New Game; No Buying; No Item Box)
Chapter 5-3 is the longest chapter in the entire game and offers some (interesting) challenges like Reaper, a moving platform, a lot of lickers, and a very special boss fight at the end.
The problem with the Jill-Wekser fight, however, is that the A.I. does not know how to avoid getting shot by Jill, so you must take out Jill first before attacking Wesker. The easiest way to damage Wesker is to use stealth shots or when he does a spin attack, but you can also damage him while he does a forward kick or a slide attack. Three K.O. Combos and an additional shot should finish the fight - if Jill hasn't ruined you day before.
There is a way to stun Jill without the aid of your Partner. Get close to her, move left or right until she tries to kick you, and then dodge to the left or right and move backwards. You will see the option to throw here like you would have done the dodge QTE successfully.
Details about this challenge walkthrough can be seen on the playlist of this series:
https://www.youtube.com/playlist?list=PL0jciOZeBl6KO5NppU7TgFuROM8El9EpP
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