Have you ever wondered what would big ToB battles look like without active pause, and without pausing in inventory? I did, and let me tell you this run was wild. Especially the last battle seemed impossible, even with all the cheesy tactics I could think of like chaining Time Stops and Protection from Magic scrolls. But with a some practice and a hefty dose of luck I managed to beat it without turning into a Ravager (which is bugged and can be unkillable).
Everything up to the final fight I deem doable on no-reload, albeit extremely difficult. Final fight... would require hours and hours of practice to maybe pull it off.
Annoying sound you can hear is the heal-on-hit effect from Silver Dragon scale armor, from Dorn's ToB quest. In hindsight I should have disabled it somehow.
SCS 35.21 + Ascension, Double Damage Insane fine tuned to LoB, Dwarven Defender MC