Top 20 Saddest Grey's Anatomy Character Deaths

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Published on October 2, 2025 10:00:21 PM ● Video Link: https://www.youtube.com/watch?v=L9FdV3EuFzk

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Grab the tissues—this one hurts. Join us as we revisit the most heartbreaking farewells in Grey’s Anatomy history. Our countdown includes Derek Shepherd, George O’Malley, Lexie Grey, Mark Sloan, Denny Duquette, and more beloved characters whose exits shattered us. We also remember Susan Grey’s sudden post-op decline, Craig Thomas collapsing in the OR, Doc the Dog’s mercy goodbye, Adele Webber’s heartbreaking fade, Dylan Young’s sacrifice, Samuel Norbert Avery’s brief life, and Andrew DeLuca’s shocking end. Spoilers ahead!\n\nFOLLOW all our socials for more content here: https://linktr.ee/msmojo\n\nDon't forget to play our Live Trivia games at 3pm EST for a chance to win cash! The faster you answer, the more points you get!: https://www.watchmojo.com/play\n\nMsMojo is a leading producer of reference online video content of Top 10 Lists, Origins, Biographies, Commentary and more on Pop Culture, Celebrity, Movies, Music, TV, Film, Video Games, Politics, News, Comics, Superheroes. Your trusted authority on ranking Pop Culture.\n\nGreysAnatomy, MeredithGrey, DerekShepherd, GeorgeOMalley, LexieGrey, MarkSloan, DennyDuquette, AndrewDeLuca, CristinaYang, SeattleGrace, TVDeaths