| 1. | brimstone + haemolacria + flat stone | 115,658 | | The Binding of Isaac: Rebirth
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| 2. | what is the maximum number of eyes isaac can have? | 82,437 | | The Binding of Isaac: Rebirth
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| 3. | the binding of isaac enemy cosplay | soul sucker | 81,292 | | The Binding of Isaac: Rebirth
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| 4. | obtaining literal drip in isaac | 58,971 | | The Binding of Isaac: Rebirth
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| 5. | is it possible to recreate pong in isaac? | 54,089 | | The Binding of Isaac: Rebirth
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| 6. | the isaac big spender build | 53,970 | | The Binding of Isaac: Rebirth
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| 7. | what does giving isaac every bone look like? | 52,162 | | The Binding of Isaac: Rebirth
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| 8. | the isaac back to school build | 47,706 | | The Binding of Isaac: Rebirth
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| 9. | how does the kill switch really work? | 47,169 | | The Binding of Isaac: Rebirth
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| 10. | one of my favorite isaac synergies | 46,023 | | The Binding of Isaac: Rebirth
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| 11. | the isaac saint and sinner build | 45,253 | | The Binding of Isaac: Rebirth
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| 12. | the binding of isaac enemy cosplay | blister | 34,631 | | The Binding of Isaac: Rebirth
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| 13. | is it possible to beat isaac without jumping? | 29,712 | | The Binding of Isaac: Rebirth
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| 14. | the binding of isaac boss cosplay | little horn | 27,412 | | The Binding of Isaac: Rebirth
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| 15. | the binding of isaac boss cosplay | the haunt | 23,800 | | The Binding of Isaac: Rebirth
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| 16. | inventing TIMERS!! for isaac minigames | 23,505 | | The Binding of Isaac: Rebirth
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| 17. | the binding of isaac enemy cosplay | mom's dead hand | 23,397 | | The Binding of Isaac: Rebirth
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| 18. | the isaac time traveler build | 21,991 | | The Binding of Isaac: Rebirth
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| 19. | the isaac malpractice build | 20,453 | Let's Play | The Binding of Isaac: Rebirth
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| 20. | soy creep | the binding of isaac enemy cosplay | 16,959 | | The Binding of Isaac: Rebirth
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| 21. | the binding of isaac enemy cosplay | charger | 15,062 | | The Binding of Isaac: Rebirth
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| 22. | what's the secret of this fireplace? | 13,747 | | The Binding of Isaac: Rebirth
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| 23. | which familiar types is isaac able to control? | 13,730 | | The Binding of Isaac: Rebirth
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| 24. | a brief and inadequate explanation of cosmetic layers | 8,048 | | The Binding of Isaac: Rebirth
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| 25. | what happens when you create a trapdoor in the dogma fight? | 6,272 | | The Binding of Isaac: Rebirth
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| 26. | INSTAKILL on the beast glitch | 5,572 | | The Binding of Isaac: Rebirth
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| 27. | how big can the forgotten's bone get? | 3,672 | | The Binding of Isaac: Rebirth
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| 28. | Day 1 of Isaac Nuzlocke Runs! | 3,011 | | The Binding of Isaac: Rebirth
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| 29. | isaac becomes fast AND furious (but mostly fast) | 2,790 | | The Binding of Isaac: Rebirth
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| 30. | how to turn isaac into a metroidvania! | 2,740 | Guide | The Binding of Isaac: Rebirth
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| 31. | so apparently they buffed suplex... | 2,269 | | The Binding of Isaac: Rebirth
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| 32. | what happens if you put dogma in a minecart? | 2,121 | | The Binding of Isaac: Rebirth
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| 33. | Silly Isaac Runs + The Mystery Game | 1,929 | | The Binding of Isaac: Rebirth
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| 34. | how do these teleporters really work? everything you need to know about teleporting tiles! | 1,481 | | The Binding of Isaac: Rebirth
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| 35. | can we make runs even more random? | 1,220 | | The Binding of Isaac: Rebirth
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| 36. | More Isaac Repentance | 472 | | The Binding of Isaac: Rebirth
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| 37. | Isaac Repentance with EVEN MORE MODS | 435 | | The Binding of Isaac: Rebirth
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| 38. | The Binding of Isaac Repentance but I have one very powerful mod | 352 | | The Binding of Isaac: Rebirth
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