| 1. | The Binding of Isaac Rebirth - Super OP Breaking Run (E51) | 39,600 | | The Binding of Isaac: Rebirth
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| 2. | The Binding of Isaac Afterbirth: Most Overpowered Run Yet (E6 - Breaking) | 16,024 | | The Binding of Isaac: Rebirth
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| 3. | The Binding of Isaac: Rebirth Episode 1 - Amazing | 7,641 | Show | The Binding of Isaac: Rebirth
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| 4. | The Binding of Isaac: Afterbirth - Greed Mode Top Secret Room Glitch | 6,972 | | The Binding of Isaac: Rebirth
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| 5. | The Binding of Isaac: Rebirth Episode 2 - Carry | 5,407 | | The Binding of Isaac: Rebirth
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| 6. | The Binding of Isaac Rebirth - All of the Tears! (60 FPS test) | 4,933 | | The Binding of Isaac: Rebirth
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| 7. | Channel Update: Isaac? | 4,775 | | The Binding of Isaac: Rebirth
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| 8. | The Binding of Isaac Rebirth - Sonic Glitch | 4,049 | | The Binding of Isaac: Rebirth
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| 9. | The Binding of Isaac Afterbirth: Episode 1 - Additional | 3,735 | | The Binding of Isaac: Rebirth
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| 10. | The Binding of Isaac Rebirth: Episode 6 - Nerfed (But Still OP) | 3,509 | | The Binding of Isaac: Rebirth
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| 11. | The Binding of Isaac: Rebirth Episode 3 - Cursed? | 3,497 | | The Binding of Isaac: Rebirth
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| 12. | The Binding of Isaac Rebirth: Episode 8 - Hearty | 3,488 | Show | The Binding of Isaac: Rebirth
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| 13. | The Binding of Isaac Rebirth Episode 13 - Clear | 3,380 | Show | The Binding of Isaac: Rebirth
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| 14. | The Binding of Isaac Rebirth: Episode 10 - Skip | 3,332 | Show | The Binding of Isaac: Rebirth
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| 15. | The Binding of Isaac Rebirth: Episode 30 - Protected | 3,304 | Show | The Binding of Isaac: Rebirth
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| 16. | The Binding of Isaac Rebirth: Episode 15 - Unnecessary | 3,192 | Show | The Binding of Isaac: Rebirth
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| 17. | The Binding of Isaac Rebirth: Episode 29 - Sarcasm | 3,139 | Show | The Binding of Isaac: Rebirth
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| 18. | The Binding of Isaac Rebirth: Episode 19 - Michael Bay | 3,121 | Show | The Binding of Isaac: Rebirth
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| 19. | The Binding of Isaac Rebirth: Episode 4 - Return Fire | 3,102 | | The Binding of Isaac: Rebirth
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| 20. | MrIwont4get Streams Isaac - Hubris | 3,070 | | The Binding of Isaac: Rebirth
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| 21. | The Binding of Isaac Rebirth: Episode 20 - Speed | 3,065 | Show | The Binding of Isaac: Rebirth
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| 22. | The Binding of Isaac Rebirth: Episode 12 - Bad | 3,057 | Show | The Binding of Isaac: Rebirth
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| 23. | The Binding of Isaac Rebirth: Episode 14 - Tetrahedron | 3,041 | Show | The Binding of Isaac: Rebirth
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| 24. | The Binding of Isaac: AFTERBIRTH+ - Episode 1 [Delirious] | 3,006 | | The Binding of Isaac: Rebirth
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| 25. | The Binding of Isaac Rebirth: Episode 7 - Resurrection | 2,869 | Show | The Binding of Isaac: Rebirth
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| 26. | MrIwont4get Streams Isaac - Redemption | 2,856 | | The Binding of Isaac: Rebirth
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| 27. | The Binding of Isaac Afterbirth: Episode 2 - Maw | 2,802 | | The Binding of Isaac: Rebirth
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| 28. | The Binding of Isaac Rebirth: Episode 27 - Shade | 2,799 | Show | The Binding of Isaac: Rebirth
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| 29. | The Binding of Isaac - Afterbirth: All of the lasers! | 2,793 | | The Binding of Isaac: Rebirth
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| 30. | The Binding of Isaac Rebirth: Episode 26 - Jump | 2,758 | Show | The Binding of Isaac: Rebirth
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| 31. | The Binding of Isaac Rebirth: Episode 17 - Regret | 2,748 | Show | The Binding of Isaac: Rebirth
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| 32. | The Binding of Isaac Rebirth: Episode 18 - Science! | 2,738 | Show | The Binding of Isaac: Rebirth
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| 33. | The Binding of Isaac Rebirth: Episode 9 - Stab | 2,719 | Show | The Binding of Isaac: Rebirth
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| 34. | MrIwont4get Streams Isaac - Positive | 2,706 | | The Binding of Isaac: Rebirth
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| 35. | The Binding of Isaac Rebirth: Episode 31 - Biased | 2,648 | Show | The Binding of Isaac: Rebirth
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| 36. | The Binding of Isaac Rebirth: Episode 11 - Two | 2,627 | Show | The Binding of Isaac: Rebirth
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| 37. | The Binding of Isaac Rebirth: Episode 28 - Dwelling | 2,594 | Show | The Binding of Isaac: Rebirth
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| 38. | The Binding of Isaac Rebirth: Episode 22 - Denied | 2,590 | Show | The Binding of Isaac: Rebirth
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| 39. | The Binding of Isaac Rebirth: Episode 24 - Repeat | 2,507 | Show | The Binding of Isaac: Rebirth
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| 40. | The Binding of Isaac Rebirth: Episode 16 - Lacking | 2,506 | Show | The Binding of Isaac: Rebirth
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| 41. | The Binding of Isaac Rebirth: Episode 25 - Patience | 2,496 | Show | The Binding of Isaac: Rebirth
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| 42. | The Binding of Isaac Rebirth: Episode 5 - Bandage | 2,404 | | The Binding of Isaac: Rebirth
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| 43. | The Binding of Isaac Rebirth: Episode 36 - Incomplete | 2,380 | Show | The Binding of Isaac: Rebirth
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| 44. | MrIwont4get Streams Isaac - GG | 2,377 | | The Binding of Isaac: Rebirth
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| 45. | The Binding of Isaac Rebirth: Episode 23 - Sudden | 2,316 | Show | The Binding of Isaac: Rebirth
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| 46. | The Binding of Isaac Rebirth: Episode 32 - Drop | 2,254 | Show | The Binding of Isaac: Rebirth
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| 47. | The Binding of Isaac Afterbirth: Episode 4 - Down | 2,233 | | The Binding of Isaac: Rebirth
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| 48. | The Binding of Isaac Rebirth: Episode 33 - Saved | 2,186 | Show | The Binding of Isaac: Rebirth
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| 49. | The Binding of Isaac Rebirth: Episode 21 - Double | 2,168 | Show | The Binding of Isaac: Rebirth
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| 50. | The Binding of Isaac Rebirth: Episode 34 - Touch | 2,131 | Show | The Binding of Isaac: Rebirth
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| 51. | The Binding of Isaac Rebirth: Episode 40 - Intelligent | 2,029 | Show | The Binding of Isaac: Rebirth
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| 52. | The Binding of Isaac Afterbirth - Greed Mode | 2,025 | | The Binding of Isaac: Rebirth
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| 53. | MrIwont4get Streams Isaac - Skys! | 2,020 | | The Binding of Isaac: Rebirth
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| 54. | The Binding of Isaac Rebirth: Episode 64 - Breaking | 2,019 | | The Binding of Isaac: Rebirth
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| 55. | The Binding of Isaac Rebirth: Episode 35 - Lazarith | 2,018 | Show | The Binding of Isaac: Rebirth
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| 56. | The Binding of Isaac Rebirth: Episode 37 - Work | 2,007 | Show | The Binding of Isaac: Rebirth
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| 57. | The Binding of Isaac Rebirth: Episode 45 - Unknown | 1,982 | Show | The Binding of Isaac: Rebirth
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| 58. | The Binding of Isaac Rebirth: Episode 44 - Tears | 1,952 | Show | The Binding of Isaac: Rebirth
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| 59. | The Binding of Isaac Rebirth: Episode 39 - Dearth | 1,952 | Show | The Binding of Isaac: Rebirth
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| 60. | The Binding of Isaac Afterbirth: Episode 3 - Disconnected | 1,906 | | The Binding of Isaac: Rebirth
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| 61. | The Binding of Isaac Rebirth: Episode 42 - Technically | 1,874 | Show | The Binding of Isaac: Rebirth
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| 62. | The Binding of Isaac Rebirth: Episode 48 - Run | 1,869 | Show | The Binding of Isaac: Rebirth
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| 63. | The Binding of Isaac Afterbirth: Episode 7 - Persist (Breaking) | 1,833 | | The Binding of Isaac: Rebirth
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| 64. | The Binding of Isaac Rebirth: Episode 38 - Slow | 1,810 | Show | The Binding of Isaac: Rebirth
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| 65. | The Binding of Isaac Rebirth: Episode 55 - Delay | 1,798 | | The Binding of Isaac: Rebirth
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| 66. | The Binding of Isaac Rebirth: Episode 43 - Distraction | 1,753 | Show | The Binding of Isaac: Rebirth
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| 67. | The Binding of Isaac Rebirth: Episode 47 - Slide | 1,741 | Show | The Binding of Isaac: Rebirth
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| 68. | The Binding of Isaac Rebirth: Episode 50 - Ended | 1,729 | Show | The Binding of Isaac: Rebirth
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| 69. | The Binding of Isaac Rebirth: Episode 41 - Unyielding | 1,728 | Show | The Binding of Isaac: Rebirth
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| 70. | The Binding of Isaac: Afterbirth - There is always one... | 1,711 | | The Binding of Isaac: Rebirth
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| 71. | The Binding of Isaac Rebirth: Episode 59 - Firework | 1,709 | | The Binding of Isaac: Rebirth
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| 72. | MrIwont4get Streams Isaac - Tease | 1,690 | | The Binding of Isaac: Rebirth
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| 73. | The Binding of Isaac Rebirth: Episode 58 - Blind | 1,661 | | The Binding of Isaac: Rebirth
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| 74. | The Binding of Isaac Rebirth: Episode 53 - Pizza | 1,619 | Show | The Binding of Isaac: Rebirth
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| 75. | The Binding of Isaac Rebirth: Episode 46 - Missed | 1,578 | Show | The Binding of Isaac: Rebirth
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| 76. | The Binding of Isaac Rebirth: Episode 54 - Give | 1,560 | Show | The Binding of Isaac: Rebirth
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| 77. | The Binding of Isaac Rebirth: Episode 57 - Lost | 1,535 | | The Binding of Isaac: Rebirth
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| 78. | The Binding of Isaac Afterbirth: Episode 5 - Bill | 1,500 | | The Binding of Isaac: Rebirth
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| 79. | The Binding of Isaac Rebirth: Episode 52 - Return | 1,496 | Show | The Binding of Isaac: Rebirth
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| 80. | The Binding of Isaac Rebirth: Episode 56 - Gilded | 1,424 | | The Binding of Isaac: Rebirth
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| 81. | The Binding of Isaac Rebirth: Episode 60 - Vision | 1,389 | | The Binding of Isaac: Rebirth
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| 82. | The Binding of Isaac Afterbirth: Episode 13 - Lucky | 1,387 | | The Binding of Isaac: Rebirth
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| 83. | The Binding of Isaac Rebirth: Episode 49 - Streak | 1,383 | Show | The Binding of Isaac: Rebirth
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| 84. | The Binding of Isaac Afterbirth: Episode 8 - Cursor | 1,355 | | The Binding of Isaac: Rebirth
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| 85. | The Binding of Isaac Rebirth: Episode 61 - Panic | 1,318 | | The Binding of Isaac: Rebirth
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| 86. | The Binding of Isaac Afterbirth: Episode 11 - Altruistic (Breaking) | 1,307 | | The Binding of Isaac: Rebirth
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| 87. | The Binding of Isaac Afterbirth: Episode 27 - Implausible | 1,259 | | The Binding of Isaac: Rebirth
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| 88. | The Binding of Isaac Afterbirth: Episode 14 - Incendiary (Breaking) | 1,218 | | The Binding of Isaac: Rebirth
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| 89. | The Binding of Isaac Rebirth: Episode 62 - Destroyer | 1,215 | | The Binding of Isaac: Rebirth
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| 90. | The Binding of Isaac Afterbirth: Episode 10 - Percent | 1,194 | | The Binding of Isaac: Rebirth
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| 91. | The Binding of Isaac Afterbirth: Episode 15 - Behead | 1,125 | | The Binding of Isaac: Rebirth
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| 92. | The Binding of Isaac Afterbirth: Episode 17 - Transaction (Breaking) | 1,111 | | The Binding of Isaac: Rebirth
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| 93. | The Binding of Isaac Afterbirth: Episode 28 - Suction (Breaking) | 1,110 | | The Binding of Isaac: Rebirth
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| 94. | The Binding of Isaac Afterbirth: Episode 16 - Tap | 1,076 | | The Binding of Isaac: Rebirth
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| 95. | The Binding of Isaac: AFTERBIRTH+ - Episode 2 [Apollyon] | 1,046 | | The Binding of Isaac: Rebirth
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| 96. | The Binding of Isaac Afterbirth: Episode 12 - Signs | 1,008 | | The Binding of Isaac: Rebirth
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| 97. | The Binding of Isaac Afterbirth: Episode 23 - Reoccur (Breaking) | 1,004 | | The Binding of Isaac: Rebirth
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| 98. | The Binding of Isaac Rebirth: Episode 63 - Substantial | 984 | | The Binding of Isaac: Rebirth
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| 99. | The Binding of Isaac Afterbirth: Episode 24 - Neo | 980 | | The Binding of Isaac: Rebirth
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| 100. | The Binding of Isaac Afterbirth: Episode 9 - Impending | 972 | | The Binding of Isaac: Rebirth
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