| 1. | Super Mario Odyssey | 2,447,692 | 15.41% | 29 | 7:38:55 |
| 2. | Super Mario Bros. | 1,037,248 | 6.53% | 49 | 20:35:31 |
| 3. | Super Mario 3D Land | 701,963 | 4.42% | 9 | 2:17:49 |
| 4. | Super Mario Advance 4: Super Mario Bros. 3 | 614,149 | 3.87% | 65 | 14:38:43 |
| 5. | Super Mario World 2: Yoshi's Island | 519,382 | 3.27% | 43 | 12:54:58 |
| 6. | The Legend of Zelda: Twilight Princess | 482,489 | 3.04% | 48 | 11:10:39 |
| 7. | Mario vs. Donkey Kong 2: March of the Minis | 440,431 | 2.77% | 39 | 7:31:05 |
| 8. | Mega Man X: Command Mission | 412,866 | 2.60% | 35 | 16:01:26 |
| 9. | Mega Man X6 | 368,285 | 2.32% | 7 | 3:30:00 |
| 10. | Mario Kart Arcade GP 2 | 329,166 | 2.07% | 14 | 3:08:04 |
| 11. | Mario Sports Mix | 303,802 | 1.91% | 21 | 10:30:00 |
| 12. | Super Smash Bros. Ultimate | 258,456 | 1.63% | 5 | 2:01:00 |
| 13. | Super Mario All-Stars | 252,966 | 1.59% | 18 | 8:00:26 |
| 14. | Street Fighter IV | 231,464 | 1.46% | 19 | 9:03:14 |
| 15. | Paper Mario: Sticker Star | 208,240 | 1.31% | 29 | 5:41:14 |
| 16. | Star Fox 64 | 206,324 | 1.30% | 13 | 6:30:00 |
| 17. | Star Fox: Assault | 177,395 | 1.12% | 36 | 17:02:56 |
| 18. | Street Fighter IV | 167,828 | 1.06% | 15 | 6:30:26 |
| 19. | Mega Man 7 | 138,056 | 0.87% | 8 | 4:00:00 |
| 20. | No More Heroes | 119,014 | 0.75% | 36 | 12:17:06 |
| 21. | Monster Hunter Tri | 112,680 | 0.71% | 14 | 6:45:30 |
| 22. | Super Smash Bros. Brawl | 107,983 | 0.68% | 75 | 23:26:40 |
| 23. | Monster Hunter Portable 3rd | 98,223 | 0.62% | 22 | 10:01:57 |
| 24. | Sparkster | 93,926 | 0.59% | 20 | 4:09:14 |
| 25. | Tekken 6 | 90,460 | 0.57% | 6 | 3:00:00 |
| 26. | Pokémon Mystery Dungeon: Blue Rescue Team and Red Rescue Team | 87,684 | 0.55% | 6 | 3:00:00 |
| 27. | Pac-Man Party | 68,482 | 0.43% | 60 | 1:05:31:18 |
| 28. | Mega Man & Bass | 64,905 | 0.41% | 3 | 1:30:00 |
| 29. | Resident Evil 5 | 64,718 | 0.41% | 1 | 30:00 |
| 30. | Super Smash Bros. for Wii U | 62,424 | 0.39% | 35 | 8:18:38 |
| 31. | Mega Man 10 | 62,378 | 0.39% | 6 | 3:00:00 |
| 32. | Mario Hoops 3-on-3 | 58,335 | 0.37% | 3 | 1:30:00 |
| 33. | Tales of Destiny | 55,231 | 0.35% | 8 | 4:00:00 |
| 34. | Mega Man X7 | 54,473 | 0.34% | 5 | 2:30:00 |
| 35. | Super Smash Bros. | 52,061 | 0.33% | 15 | 4:36:00 |
| 36. | The Legend of Zelda | 47,063 | 0.30% | 6 | 1:30:49 |
| 37. | Tatsunoko vs. Capcom: Ultimate All-Stars | 46,626 | 0.29% | 40 | 16:08:05 |
| 38. | Star Fox Adventures | 44,373 | 0.28% | 4 | 2:00:00 |
| 39. | Mario Superstar Baseball | 43,573 | 0.27% | 31 | 4:11:59 |
| 40. | Mega Man 2 | 37,401 | 0.24% | 3 | 1:30:00 |
| 41. | Mario Tennis Open | 36,886 | 0.23% | 22 | 7:08:00 |
| 42. | Marvel vs. Capcom: Clash of Super Heroes | 34,708 | 0.22% | 44 | 17:32:23 |
| 43. | Pokémon FireRed and LeafGreen | 33,394 | 0.21% | 4 | 1:00:10 |
| 44. | Mario Party: Island Tour | 29,015 | 0.18% | 7 | 1:33:51 |
| 45. | Mega Man V | 25,749 | 0.16% | 1 | 15:30 |
| 46. | Nintendo Land | 22,490 | 0.14% | 5 | 2:15:30 |
| 47. | Super Smash Bros. for Nintendo 3DS | 22,190 | 0.14% | 28 | 6:42:37 |
| 48. | Mega Man Network Transmission | 15,548 | 0.10% | 3 | 46:30 |
| 49. | Mega Man: Dr. Wily's Revenge | 15,470 | 0.10% | 16 | 5:35:33 |
| 50. | Tetris DS | 15,384 | 0.10% | 2 | 1:00:00 |
| 51. | Mega Man Legends 2 | 14,797 | 0.09% | 3 | 46:30 |
| 52. | Tales of Destiny 2 | 8,490 | 0.05% | 5 | 2:30:00 |
| 53. | Thunder Force III | 7,951 | 0.05% | 16 | 6:33:42 |
| 54. | Pokémon Ranger: Guardian Signs | 7,274 | 0.05% | 29 | 8:34:44 |
| 55. | The Last Story | 4,887 | 0.03% | 7 | 3:30:00 |
| 56. | Prototype | 4,466 | 0.03% | 1 | 30:00 |
| 57. | Street Fighter X Tekken | 4,183 | 0.03% | 44 | 21:30:09 |
| 58. | Streets of Rage | 3,541 | 0.02% | 31 | 14:30:19 |
| 59. | Star Fox Command | 3,430 | 0.02% | 3 | 1:30:00 |
| 60. | Street Fighter III | 3,101 | 0.02% | 1 | 30:00 |
| 61. | Far Cry | 2,073 | 0.01% | 1 | 30:00 |
| 62. | Final Fantasy XIII | 1,978 | 0.01% | 1 | 30:00 |
| 63. | Final Fantasy V | 1,832 | 0.01% | 1 | 30:00 |
| 64. | Wii Music | 1,668 | 0.01% | 3 | 46:30 |
| 65. | Nintendogs | 1,375 | 0.01% | 1 | 30:00 |
| 66. | Mega Man | 1,280 | 0.01% | 1 | 30:00 |
| 67. | Super Mario Bros. 2 | 1,186 | 0.01% | 5 | 1:00:50 |
| 68. | Soma | 1,094 | 0.01% | 1 | 30:00 |
| 69. | Theatrhythm Final Fantasy | 1,014 | 0.01% | 2 | 1:00:00 |
| 70. | Mario Golf | 969 | 0.01% | 1 | 30:00 |
| 71. | Mario vs. Donkey Kong: Mini-Land Mayhem! | 608 | 0.00% | 2 | 31:00 |
| 72. | Anti Air | 515 | 0.00% | 1 | 30:00 |
| 73. | Super Mario World | 297 | 0.00% | 1 | 30:00 |
| 74. | Lost Planet: Extreme Condition | 228 | 0.00% | 1 | 30:00 |
| 75. | Metal Slug 3 | 195 | 0.00% | 2 | 1:00:00 |
| 76. | Super Mario RPG | 168 | 0.00% | 1 | 0:06 |
| 77. | Commando | 109 | 0.00% | 1 | 30:00 |
| 78. | Sonic Unleashed | 75 | 0.00% | 1 | 4:29 |
