| 301. | PROPTOSIS is the best and worst Item at the same time | The Binding of Isaac: Repentance | 43 | | The Binding of Isaac: Rebirth
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| 302. | Skinny Odd Mushroom had such a GLOW UP | 35 | | The Binding of Isaac: Rebirth
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| 303. | Holy Infinibrim | The Binding of Isaac: Repentance | 35 | | The Binding of Isaac: Rebirth
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| 304. | Strawman became a LEGEND | 62 | | The Binding of Isaac: Rebirth
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| 305. | This Start goes SO HARD | The Binding of Isaac: Repentance | 44 | | The Binding of Isaac: Rebirth
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| 306. | Just Add Damage | The Binding of Isaac: Repentance | 48 | | The Binding of Isaac: Rebirth
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| 307. | Toxic Warfare | 41 | | The Binding of Isaac: Rebirth
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| 308. | Lasers. Lasers Everywhere. | The Binding of Isaac: Repentance | 59 | | The Binding of Isaac: Rebirth
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| 309. | One of the oldest GG Combos | 42 | | The Binding of Isaac: Rebirth
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| 310. | Pulling the Tearspam together | The Binding of Isaac: Repentance | 50 | | The Binding of Isaac: Rebirth
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| 311. | CHAOS START! | The Binding of Isaac: Repentance | 50 | | The Binding of Isaac: Rebirth
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| 312. | Occular Rift can CARRY Runs! | 43 | | The Binding of Isaac: Rebirth
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| 313. | Wiggly Scythes | The Binding of Isaac: Repentance | 50 | | The Binding of Isaac: Rebirth
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| 314. | CHAOS is the KING of Greed Mode! | 52 | | The Binding of Isaac: Rebirth
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| 315. | One of the OG BUSTED Combos! | The Binding of Isaac: Repentance | 48 | | The Binding of Isaac: Rebirth
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| 316. | Winning in Room 1 | The Binding of Isaac: Repentance | 52 | | The Binding of Isaac: Rebirth
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| 317. | This run was UNBELIEVABLE | 49 | | The Binding of Isaac: Rebirth
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| 318. | This run was just RIDICULOUS | The Binding of Isaac: Repentance | 57 | | The Binding of Isaac: Rebirth
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| 319. | Ultimate FLY BUILD! | 82 | | The Binding of Isaac: Rebirth
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| 320. | I tried out BUFFED MARS so you don't have to | The Binding of Isaac: Repentance | 46 | | The Binding of Isaac: Rebirth
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| 321. | My First Rep+ Run featured BRIMSANITY | The Binding of Isaac: Repentance | 68 | | The Binding of Isaac: Rebirth
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| 322. | Pew Pew Goes the Holy Light | 32 | | The Binding of Isaac: Rebirth
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| 323. | MISSILE BOMBS require some good Defenses | The Binding of Isaac: Repentance | 43 | | The Binding of Isaac: Rebirth
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| 324. | Light and Darkness | The Binding of Isaac: Repentance | 39 | | The Binding of Isaac: Rebirth
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| 325. | Vortex of Scythes | The Binding of Isaac: Repentance | 51 | | The Binding of Isaac: Rebirth
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| 326. | The Start of Starts | The Binding of Isaac: Repentance | 64 | | The Binding of Isaac: Rebirth
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| 327. | Black Ring of DESTRUCTION | The Binding of Isaac: Repentance | 63 | | The Binding of Isaac: Rebirth
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| 328. | I found all of the BEST BOX SYNERGIES | The Binding of Isaac: Repentance | 40 | | The Binding of Isaac: Rebirth
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| 329. | Big Isaac, Little Twins | The Binding of Isaac: Repentance | 40 | | The Binding of Isaac: Rebirth
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| 330. | Tear Spam and Tech Zero leads to DESTRUCTION | The Binding of Isaac: Repentance | 60 | | The Binding of Isaac: Rebirth
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| 331. | This Combo is ABSURD | The Binding of Isaac: Repentance | 37 | | The Binding of Isaac: Rebirth
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| 332. | Average Streamer Run | The Binding of Isaac: Repentance | 58 | | The Binding of Isaac: Rebirth
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| 333. | SO. MANY. SCYTHES. | The Binding of Isaac: Repentance | 44 | | The Binding of Isaac: Rebirth
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| 334. | Insane Damage, No Tears | The Binding of Isaac: Repentance | 44 | | The Binding of Isaac: Rebirth
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| 335. | Not Only Strong in Greedier | The Binding of Isaac: Repentance | 50 | | The Binding of Isaac: Rebirth
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| 336. | Soy Milk Start to DELIRIUM | The Binding of Isaac: Repentance | 40 | | The Binding of Isaac: Rebirth
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| 337. | No Holes | The Binding of Isaac: Repentance | 48 | | The Binding of Isaac: Rebirth
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| 338. | Ipecacubus | The Binding of Isaac: Repentance | 48 | | The Binding of Isaac: Rebirth
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| 339. | A Cat and his Succubus | The Binding of Isaac: Repentance | 33 | | The Binding of Isaac: Rebirth
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| 340. | Close | The Binding of Isaac: Repentance | 47 | | The Binding of Isaac: Rebirth
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| 341. | I got handed this SPEEDRUN BUILD so I just went with it | The Binding of Isaac: Repentance | 37 | | The Binding of Isaac: Rebirth
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| 342. | More like Machine Gun Milk | The Binding of Isaac: Repentance | 76 | | The Binding of Isaac: Rebirth
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| 343. | Eden Roulette LIVE | 8 | |
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| 344. | Shielded Tear Barrage | 41 | | The Binding of Isaac: Rebirth
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| 345. | Fist BARRAGE | The Binding of Isaac: Repentance | 52 | | The Binding of Isaac: Rebirth
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| 346. | Ordinarily Overpowered | The Binding of Isaac: Repentance | 56 | | The Binding of Isaac: Rebirth
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| 347. | I blundered hard, but Haemo was there for me | 32 | | The Binding of Isaac: Rebirth
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| 348. | So. Many. BABIES. | 47 | | The Binding of Isaac: Rebirth
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| 349. | SUPER FRIENDS | 40 | | The Binding of Isaac: Rebirth
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| 350. | Shopping Spree | The Binding of Isaac: Repentance | 42 | | The Binding of Isaac: Rebirth
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| 351. | Slay the Spire 2 LIVE | 4 | |
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| 352. | A Big Lasers Solves All Problems | 35 | | The Binding of Isaac: Rebirth
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| 353. | DEAD EYE and HOMING go Hand in Hand (Godhead helps too I guess) | 76 | | The Binding of Isaac: Rebirth
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| 354. | Eve's Mascara is LEGIT Now! | The Binding of Isaac: Repentance | 48 | | The Binding of Isaac: Rebirth
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| 355. | I gave a Baby a Laser | 31 | | The Binding of Isaac: Rebirth
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| 356. | I had to go to Mega Satan and this was the best I got | 33 | | The Binding of Isaac: Rebirth
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| 357. | Zapping my Way to Victory | 45 | | The Binding of Isaac: Rebirth
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| 358. | Absurd Laser Build | The Binding of Isaac: Repentance | 68 | | The Binding of Isaac: Rebirth
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| 359. | Start so good it's impossible to lose | 50 | | The Binding of Isaac: Rebirth
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| 360. | Bouncy Ball Bath | 43 | | The Binding of Isaac: Rebirth
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| 361. | My Most Absurd GOD HEAD Build this Year | 53 | | The Binding of Isaac: Rebirth
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| 362. | Maybe this was a BAD Idea... | The Binding of Isaac: Repentance | 37 | | The Binding of Isaac: Rebirth
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| 363. | Just Good Old-Fashioned Tears | 46 | | The Binding of Isaac: Rebirth
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| 364. | I found my FAVOURITE Item and DESTROYED everything | The Binding of Isaac: Repentance | 42 | | The Binding of Isaac: Rebirth
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| 365. | Homing Lasers from Heaven | 86 | | The Binding of Isaac: Rebirth
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| 366. | HOMING is Split Shot's BEST FRIEND | The Binding of Isaac: Repentance | 67 | | The Binding of Isaac: Rebirth
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| 367. | Adding some Lasers to my Lasers | 38 | | The Binding of Isaac: Rebirth
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| 368. | Buff Pair | The Binding of Isaac: Repentance | 53 | | The Binding of Isaac: Rebirth
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| 369. | Bouncy Lasers are the best kind of Lasers | 57 | | The Binding of Isaac: Rebirth
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| 370. | My FAVOURITE Angel Item loves HOMING | The Binding of Isaac: Repentance | 45 | | The Binding of Isaac: Rebirth
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| 371. | Very speyecy build | The Binding of Isaac: Repentance | 45 | | The Binding of Isaac: Rebirth
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| 372. | I tried out BUFFED ABYSS so you don't have to | The Binding of Isaac: Repentance | 55 | | The Binding of Isaac: Rebirth
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| 373. | Big Brim | The Binding of Isaac: Repentance | 59 | | The Binding of Isaac: Rebirth
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| 374. | S P I N D O W N | 45 | | The Binding of Isaac: Rebirth
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| 375. | TRIPLE SHOT and LODESTONE go Hand in Hand! | The Binding of Isaac: Repentance | 36 | | The Binding of Isaac: Rebirth
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| 376. | Ultimate Firespam | The Binding of Isaac: Repentance | 56 | | The Binding of Isaac: Rebirth
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| 377. | There is hope for Random Teammates after all | The Binding of Isaac: Repentance | 28 | | The Binding of Isaac: Rebirth
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| 378. | These two are SO MUCH FUN together | 45 | | The Binding of Isaac: Rebirth
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| 379. | Angelic Brimflection | The Binding of Isaac: Repentance | 31 | | The Binding of Isaac: Rebirth
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| 380. | This was surprisingly effective | The Binding of Isaac: Repentance | 39 | | The Binding of Isaac: Rebirth
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| 381. | Spectral Goes HARD With Jacob's Ladder | The Binding of Isaac: Repentance | 49 | | The Binding of Isaac: Rebirth
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| 382. | My Most INSANE Run of 2025 | 60 | | The Binding of Isaac: Rebirth
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| 383. | Run so good the RED STEW never runs out | The Binding of Isaac: Repentance | 56 | | The Binding of Isaac: Rebirth
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| 384. | The KINGS of CLUTCH! | The Binding of Isaac: Repentance | 35 | | The Binding of Isaac: Rebirth
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| 385. | Actual Backstabs | 41 | | The Binding of Isaac: Rebirth
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| 386. | Twisted Pair leads to the WILDEST Tear Builds | 52 | | The Binding of Isaac: Rebirth
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| 387. | Literal Backstabbing | The Binding of Isaac: Repentance | 37 | | The Binding of Isaac: Rebirth
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| 388. | GELLO EVERY ROOM | 33 | | The Binding of Isaac: Rebirth
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| 389. | We have Mega Blast at Home | 40 | | The Binding of Isaac: Rebirth
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| 390. | Magneticac | The Binding of Isaac: Repentance | 42 | | The Binding of Isaac: Rebirth
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| 391. | Big Boy Blast | The Binding of Isaac: Repentance | 44 | | The Binding of Isaac: Rebirth
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| 392. | Classic R Key Experience | 52 | | The Binding of Isaac: Rebirth
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| 393. | This FLOOR 0 WIN just kept improving | 50 | | The Binding of Isaac: Rebirth
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| 394. | Rollercoaster | The Binding of Isaac: Repentance | 49 | | The Binding of Isaac: Rebirth
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| 395. | THE DREAM | The Binding of Isaac: Repentance | 72 | | The Binding of Isaac: Rebirth
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| 396. | These two were MADE FOR EACH OTHER | 46 | | The Binding of Isaac: Rebirth
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| 397. | This Brim Synergy is AWKWARD but FUN | 49 | | The Binding of Isaac: Rebirth
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| 398. | Double the Triple | The Binding of Isaac: Repentance | 35 | | The Binding of Isaac: Rebirth
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| 399. | Bigger Brim | The Binding of Isaac: Repentance | 42 | | The Binding of Isaac: Rebirth
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| 400. | I finally used it. | 61 | | The Binding of Isaac: Rebirth
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