| 1. | The Original Binding of Isaac | 11,415 | | The Binding of Isaac
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| 2. | BEST OF LEONARD | 10,410 | | The Binding of Isaac
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| 3. | Best of Tim... and Hutts | 8,382 | | The Binding of Isaac
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| 4. | I'm Retiring from Isaac... (Not really) | 7,555 | | The Binding of Isaac
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| 5. | The Binding of Isaac: Four Souls - UNBOXING | 6,075 | | The Binding of Isaac
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| 6. | The Binding of Isaac VR EXPERIMENT! [HTC Vive] | 4,876 | | The Binding of Isaac
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| 7. | Thanks, I hate this challenge... | 4,103 | | The Binding of Isaac
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| 8. | Best of Hutts 16.5 | 3,755 | | The Binding of Isaac
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| 9. | ISAAC'S BEST RUN [EPIC LASER] - The Binding of Isaac #11 | 3,423 | | The Binding of Isaac
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| 10. | Best of Hutts 7 | 3,001 | | The Binding of Isaac
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| 11. | New Character, Tarnished Eden | 2,737 | | The Binding of Isaac
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| 12. | Best of Hutts 10 | 2,174 | | The Binding of Isaac
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| 13. | We Raised Over $4,000 for Childrens' Cancer Research, and NEW VLOG CHANNEL | 1,135 | Vlog | The Binding of Isaac
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| 14. | Yolo Series 2 - Binding of Isaac | 376 | | The Binding of Isaac
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| 15. | Rebirth Mod - Heretic Mod [2] | 357 | | The Binding of Isaac
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| 16. | TOO MUCH HEALTH - The Binding of Isaac #6 | 310 | | The Binding of Isaac
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| 17. | 🧠🧠Third Save File Eden Post-it💩💩Late night chats with Edmund McMillen🤯🤯St. Jude Play Live (!StJude) | 278 | | The Binding of Isaac
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| 18. | Filled to the BRIMSTONE - Binding of Isaac #7 | 74 | | The Binding of Isaac
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| 19. | Let's Play The Binding of Isaac - Back to Basics | 68 | Let's Play | The Binding of Isaac
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| 20. | I Love This Game - The Binding of Isaac [18] | 59 | | The Binding of Isaac
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| 21. | UNLUCKIEST RUN EVER - The Binding of Isaac [12] | 58 | | The Binding of Isaac
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| 22. | NEW STUFF! - Isaac COMMUNITY REMIX | 52 | | The Binding of Isaac
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| 23. | Yolo Series 3 - Binding of Isaac - LAAASSSERRSS ZZZZT | 52 | | The Binding of Isaac
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| 24. | 24 HOUR STREAM TODAY - Isaac New Save, GIVEAWAYS, and more! | 47 | | The Binding of Isaac
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| 25. | Brimstone was a MISTAKE -- Binding of Isaac #9 | 40 | | The Binding of Isaac
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| 26. | NO LIFE!? -- The Binding of Isaac #8 | 38 | | The Binding of Isaac
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| 27. | Double Mom's Knife?! -- Binding of Isaac [25] | 36 | | The Binding of Isaac
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| 28. | The Binding of Isaac Challenge #1 - Curse of Darkness | 36 | | The Binding of Isaac
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| 29. | Too Risky - Hutts Plays Binding of Isaac [13] | 36 | Let's Play | The Binding of Isaac
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| 30. | Let's Play The Binding of Isaac - Back to Basics (Part 2) | 36 | Let's Play | The Binding of Isaac
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| 31. | Brimstone FTW - Lets Play Binding of Isaac - Yolo Series #4 | 33 | Let's Play | The Binding of Isaac
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| 32. | F!@# You Isaac -- The Binding of Isaac [15] | 30 | | The Binding of Isaac
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| 33. | Isaac Was Good Today -- Challenge Run #9 | 29 | | The Binding of Isaac
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| 34. | Quest to the CHEST! - Binding of Isaac [17] | 29 | | The Binding of Isaac
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| 35. | Meat 4EVAR!! - Isaac Challenge Run [7] | 28 | | The Binding of Isaac
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| 36. | I BLEW IT - Isaac PURIST CHALLENGE | 26 | | The Binding of Isaac
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| 37. | Fantastically Annoying - The Binding of Isaac [14] | 26 | | The Binding of Isaac
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| 38. | The Doctor's Revenge! - Isaac Challenge #6 | 25 | | The Binding of Isaac
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| 39. | SpiderBoy! -- Challenge Run #8 | 23 | | The Binding of Isaac
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| 40. | Random Run! - Binding of Isaac [19] | 21 | | The Binding of Isaac
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| 41. | Slice and Dice - Binding of Isaac [20] | 20 | | The Binding of Isaac
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| 42. | Too Much Damage? - Binding of Isaac [22] | 20 | | The Binding of Isaac
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| 43. | Effed by the Devil's long black... horns -- Lets play Binding of Isaac - Yolo #5 | 18 | Let's Play | The Binding of Isaac
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| 44. | You've Gotta Be Kidding Me - Binding of Isaac [21] | 18 | | The Binding of Isaac
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| 45. | Closest Isaac Fight - Hutts Highlights | 17 | | The Binding of Isaac
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| 46. | Screwed... maybe - Binding of Isaac [29] | 16 | | The Binding of Isaac
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