| 1. | The Original Binding of Isaac | 897,035 | | The Binding of Isaac
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| 2. | ISAAC'S BEST RUN [EPIC LASER] - The Binding of Isaac #11 | 556,166 | | The Binding of Isaac
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| 3. | The Binding of Isaac VR EXPERIMENT! [HTC Vive] | 281,524 | | The Binding of Isaac
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| 4. | Best of Hutts 7 | 219,723 | | The Binding of Isaac
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| 5. | BEST OF LEONARD | 189,996 | | The Binding of Isaac
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| 6. | Best of Hutts 10 | 154,642 | | The Binding of Isaac
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| 7. | The Binding of Isaac: Four Souls - UNBOXING | 150,996 | | The Binding of Isaac
|
| 8. | Best of Tim... and Hutts | 132,568 | | The Binding of Isaac
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| 9. | I'm Retiring from Isaac... (Not really) | 123,345 | | The Binding of Isaac
|
| 10. | Best of Hutts 16.5 | 110,745 | | The Binding of Isaac
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| 11. | Thanks, I hate this challenge... | 87,488 | | The Binding of Isaac
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| 12. | New Character, Tarnished Eden | 59,754 | | The Binding of Isaac
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| 13. | Rebirth Mod - Heretic Mod [2] | 38,401 | | The Binding of Isaac
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| 14. | We Raised Over $4,000 for Childrens' Cancer Research, and NEW VLOG CHANNEL | 25,354 | Vlog | The Binding of Isaac
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| 15. | TOO MUCH HEALTH - The Binding of Isaac #6 | 18,377 | | The Binding of Isaac
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| 16. | Yolo Series 2 - Binding of Isaac | 11,771 | | The Binding of Isaac
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| 17. | 🧠🧠Third Save File Eden Post-it💩💩Late night chats with Edmund McMillen🤯🤯St. Jude Play Live (!StJude) | 8,459 | | The Binding of Isaac
|
| 18. | Filled to the BRIMSTONE - Binding of Isaac #7 | 4,393 | | The Binding of Isaac
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| 19. | 24 HOUR STREAM TODAY - Isaac New Save, GIVEAWAYS, and more! | 3,714 | | The Binding of Isaac
|
| 20. | I Love This Game - The Binding of Isaac [18] | 3,475 | | The Binding of Isaac
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| 21. | NEW STUFF! - Isaac COMMUNITY REMIX | 2,633 | | The Binding of Isaac
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| 22. | The Binding of Isaac Challenge #1 - Curse of Darkness | 2,529 | | The Binding of Isaac
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| 23. | UNLUCKIEST RUN EVER - The Binding of Isaac [12] | 2,438 | | The Binding of Isaac
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| 24. | Brimstone was a MISTAKE -- Binding of Isaac #9 | 2,363 | | The Binding of Isaac
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| 25. | Double Mom's Knife?! -- Binding of Isaac [25] | 2,269 | | The Binding of Isaac
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| 26. | Let's Play The Binding of Isaac - Back to Basics | 2,003 | Let's Play | The Binding of Isaac
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| 27. | NO LIFE!? -- The Binding of Isaac #8 | 1,818 | | The Binding of Isaac
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| 28. | Yolo Series 3 - Binding of Isaac - LAAASSSERRSS ZZZZT | 1,615 | | The Binding of Isaac
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| 29. | Too Risky - Hutts Plays Binding of Isaac [13] | 1,468 | Let's Play | The Binding of Isaac
|
| 30. | Fantastically Annoying - The Binding of Isaac [14] | 1,301 | | The Binding of Isaac
|
| 31. | F!@# You Isaac -- The Binding of Isaac [15] | 1,246 | | The Binding of Isaac
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| 32. | Quest to the CHEST! - Binding of Isaac [17] | 1,144 | | The Binding of Isaac
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| 33. | Brimstone FTW - Lets Play Binding of Isaac - Yolo Series #4 | 1,090 | Let's Play | The Binding of Isaac
|
| 34. | Isaac Was Good Today -- Challenge Run #9 | 1,004 | | The Binding of Isaac
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| 35. | The Doctor's Revenge! - Isaac Challenge #6 | 912 | | The Binding of Isaac
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| 36. | Random Run! - Binding of Isaac [19] | 890 | | The Binding of Isaac
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| 37. | I BLEW IT - Isaac PURIST CHALLENGE | 859 | | The Binding of Isaac
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| 38. | Meat 4EVAR!! - Isaac Challenge Run [7] | 856 | | The Binding of Isaac
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| 39. | Too Much Damage? - Binding of Isaac [22] | 742 | | The Binding of Isaac
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| 40. | SpiderBoy! -- Challenge Run #8 | 701 | | The Binding of Isaac
|
| 41. | You've Gotta Be Kidding Me - Binding of Isaac [21] | 680 | | The Binding of Isaac
|
| 42. | Let's Play The Binding of Isaac - Back to Basics (Part 2) | 662 | Let's Play | The Binding of Isaac
|
| 43. | Screwed... maybe - Binding of Isaac [29] | 583 | | The Binding of Isaac
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| 44. | Effed by the Devil's long black... horns -- Lets play Binding of Isaac - Yolo #5 | 580 | Let's Play | The Binding of Isaac
|
| 45. | Slice and Dice - Binding of Isaac [20] | 266 | | The Binding of Isaac
|
| 46. | Closest Isaac Fight - Hutts Highlights | 240 | | The Binding of Isaac
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