| 401. | They Made A NEW Gamemode In Isaac FOR ME? | 59 | | The Binding of Isaac: Rebirth
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| 402. | They Made Gambling Into A Character, It Was A Mistake. | 53 | | The Binding of Isaac: Rebirth
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| 403. | How Deals CARRIED This Run | 42 | | The Binding of Isaac: Rebirth
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| 404. | How One Room Changed Our WHOLE Game | 43 | | The Binding of Isaac: Rebirth
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| 405. | This NEW Item Changes EVERYTHING | 45 | | The Binding of Isaac: Rebirth
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| 406. | Is This The BEST Secret Room Item? | 44 | | The Binding of Isaac: Rebirth
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| 407. | T. Lost's "Better Items" Are INSANE | 44 | | The Binding of Isaac: Rebirth
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| 408. | Least RIGGED Youtuber Run | 44 | | The Binding of Isaac: Rebirth
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| 409. | The BEST Item In The Game CARRIED This Run | 44 | | The Binding of Isaac: Rebirth
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| 410. | This DELIRIUM Mod Made Me Go CRAZY. | 66 | | The Binding of Isaac: Rebirth
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| 411. | The MOST EXPLOSIVE Brimstone Build | 46 | | The Binding of Isaac: Rebirth
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| 412. | How BROKEN Did They Make This Character? | 46 | | The Binding of Isaac: Rebirth
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| 413. | Isaac's BIGGEST Update Is Coming | 47 | Vlog | The Binding of Isaac: Rebirth
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| 414. | The Most RIGGED Secret Room Run | 47 | | The Binding of Isaac: Rebirth
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| 415. | This NEW Forgotten Rework Is AMAZING | 46 | | The Binding of Isaac: Rebirth
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| 416. | They Made CHAOS Into A Dice, It's INSANE. | 64 | | The Binding of Isaac: Rebirth
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| 417. | This NEW Item Makes Isaac HARDER | 54 | | The Binding of Isaac: Rebirth
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| 418. | The MOST EXPLOSIVE Synergy In The Game | 48 | | The Binding of Isaac: Rebirth
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| 419. | Isaac's Most Broken Item, But I'm ALWAYS Blind! | 52 | | The Binding of Isaac: Rebirth
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| 420. | This NEW Character Is ABSOLUTELY Broken | 60 | | The Binding of Isaac: Rebirth
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| 421. | T. Cain = INSANE Synergies | 49 | | The Binding of Isaac: Rebirth
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| 422. | I Gave Isaac EVERY Item Possible. It Was A Mistake. | 62 | | The Binding of Isaac: Rebirth
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| 423. | The FASTEST Mega Satan Kill | 49 | | The Binding of Isaac: Rebirth
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| 424. | How We Broke EVERYTHING With QUALITY 4 Items | 49 | | The Binding of Isaac: Rebirth
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| 425. | Making Every Boss Look EASY | 49 | | The Binding of Isaac: Rebirth
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| 426. | The UNLUCKIEST Modded Isaac Run Ever. | 93 | | The Binding of Isaac: Rebirth
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| 427. | How These NEW Tainted Items Broke My Run | 64 | | The Binding of Isaac: Rebirth
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| 428. | This Made TWISTED PAIR Look WEAK | 51 | | The Binding of Isaac: Rebirth
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| 429. | This Run Was INSANE! | 51 | | The Binding of Isaac: Rebirth
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| 430. | The MOST DANGEROUS Build In The Game | 51 | | The Binding of Isaac: Rebirth
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| 431. | The CRAZIEST Run In The Game | 52 | | The Binding of Isaac: Rebirth
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| 432. | This NEW Challenge Made Me Break EVERY Limit. | 58 | | The Binding of Isaac: Rebirth
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| 433. | The Most RIGGED Blue Baby Run | 52 | | The Binding of Isaac: Rebirth
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| 434. | This Character Was A Mistake. | 59 | | The Binding of Isaac: Rebirth
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| 435. | I Found The MOST MEME Item In Isaac, It's BROKEN! | 54 | | The Binding of Isaac: Rebirth
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| 436. | This VOID REWORK Makes The Item FINALLY Broken! | 54 | | The Binding of Isaac: Rebirth
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| 437. | This Start CARRIED Our Whole Game | 52 | | The Binding of Isaac: Rebirth
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| 438. | I Found The EASIEST Character In Isaac, He Is Broken. | 62 | | The Binding of Isaac: Rebirth
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| 439. | How One Item DESTROYED Our Whole Run | 53 | | The Binding of Isaac: Rebirth
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| 440. | How I Got EVERY ITEM In The Game | 53 | | The Binding of Isaac: Rebirth
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| 441. | Isaac Challenges Are So BROKEN | 54 | | The Binding of Isaac: Rebirth
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| 442. | The EASIEST Modded Character In ISAAC? | 60 | | The Binding of Isaac: Rebirth
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| 443. | The Most UNDERRATED Synergy | 55 | | The Binding of Isaac: Rebirth
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| 444. | This INSANE Synergy Broke Our Game | 57 | | The Binding of Isaac: Rebirth
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| 445. | Is This The BIGGEST Isaac Update Yet? | 58 | Vlog | The Binding of Isaac: Rebirth
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| 446. | They Added HUSH As A Playable Character, It's Insane. | 82 | | The Binding of Isaac: Rebirth
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| 447. | DEMOLISHING Every Single Boss | 59 | | The Binding of Isaac: Rebirth
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| 448. | I Found The BEST Quality4 Item, It Broke EVERYTHING. | 63 | | The Binding of Isaac: Rebirth
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| 449. | The MOST RIGGED Devil Deals Of All Time? | 60 | | The Binding of Isaac: Rebirth
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| 450. | The Genesis Incident | 60 | | The Binding of Isaac: Rebirth
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| 451. | How I RIGGED On A NEW File! | 60 | | The Binding of Isaac: Rebirth
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| 452. | We RIGGED Isaac Challenges | 60 | | The Binding of Isaac: Rebirth
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| 453. | I Found The Most BROKEN Treasure In Isaac's History! | 64 | | The Binding of Isaac: Rebirth
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| 454. | They Added A NEW Dice To Isaac, It's BROKEN. | 62 | | The Binding of Isaac: Rebirth
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| 455. | The LUCKIEST Isaac Run Ever? | 61 | | The Binding of Isaac: Rebirth
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| 456. | They FINALLY Updated The BEST Modded Character In Isaac! | 63 | | The Binding of Isaac: Rebirth
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| 457. | Glitched Crown Spawned EVERY Item In The Game | 62 | | The Binding of Isaac: Rebirth
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| 458. | The MOST BROKEN Angel Deal | 62 | | The Binding of Isaac: Rebirth
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| 459. | Tainted Lost Is INSANELY Broken | 64 | | The Binding of Isaac: Rebirth
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| 460. | Breaking Isaac With The WORST Items | 63 | | The Binding of Isaac: Rebirth
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| 461. | I Got The FASTEST Rig In All Of Isaac! | 71 | | The Binding of Isaac: Rebirth
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| 462. | How I Broke Isaac With A MASSIVE Rifle. | 88 | | The Binding of Isaac: Rebirth
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| 463. | They Made Glitched Crown Into A Dice, It''s Insane. | 66 | | The Binding of Isaac: Rebirth
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| 464. | This NEW Character Is Strangely Broken. | 77 | | The Binding of Isaac: Rebirth
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| 465. | They Gave GodHead A MASSIVE Upgrade, It's Broken. | 69 | | The Binding of Isaac: Rebirth
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| 466. | This NEW Tech Item Is BROKEN | 67 | | The Binding of Isaac: Rebirth
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| 467. | The MOST BROKEN Run To The SECRET File! | 65 | | The Binding of Isaac: Rebirth
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| 468. | How One Item CARRIED Our Whole Run | 66 | | The Binding of Isaac: Rebirth
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| 469. | How I RIGGED The Forgotten Unlock | 67 | | The Binding of Isaac: Rebirth
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| 470. | The MOST INSANE Isaac Run Ever | 66 | | The Binding of Isaac: Rebirth
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| 471. | These Bosses Had NO CHANCE | 66 | | The Binding of Isaac
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| 472. | This NEW Character Is Surpisingly DIFFICULT? | 69 | | The Binding of Isaac: Rebirth
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| 473. | We Rigged On A BRAND NEW File! | 66 | | The Binding of Isaac: Rebirth
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| 474. | How Genesis COMPLETELY RIGGED This Run | 67 | | The Binding of Isaac: Rebirth
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| 475. | This NEW Character Is Absolutely INSANE | 75 | | The Binding of Isaac: Rebirth
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| 476. | This Bethany Synergy Is AWESOME | 68 | | The Binding of Isaac: Rebirth
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| 477. | This Is The WEIRDEST Modded Character! | 77 | | The Binding of Isaac: Rebirth
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| 478. | They Made PABLO Into A Playable Character, And She's BROKEN. | 82 | | The Binding of Isaac: Rebirth
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| 479. | They FINALLY Released The HIDDEN Antibirth Character! | 70 | | The Binding of Isaac: Rebirth
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| 480. | I Found The NEW Best Item In Isaac! | 105 | | The Binding of Isaac: Rebirth
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| 481. | The ULTIMATE Youtuber Run Luck | 71 | | The Binding of Isaac: Rebirth
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| 482. | The NEW Character Is AMAZING | 72 | | The Binding of Isaac: Rebirth
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| 483. | The BEST Item In The Game RUINED This Run | 71 | | The Binding of Isaac: Rebirth
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| 484. | How We RIGGED Every Quality4 Item | 72 | | The Binding of Isaac: Rebirth
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| 485. | I Tried To Get INFINITE Stats With Damocles, This Is How It Went. | 74 | | The Binding of Isaac: Rebirth
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| 486. | This NEW Character Has The BEST Mechanics In Isaac! | 77 | | The Binding of Isaac: Rebirth
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| 487. | They Added CHAINSAWMAN To Isaac! | 85 | | The Binding of Isaac: Rebirth
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| 488. | They FINALLY Added Gabriel From ULTRAKILL In Isaac. | 82 | | The Binding of Isaac: Rebirth
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| 489. | These Modded CHAMPION Characters Are AMAZING | 77 | | The Binding of Isaac: Rebirth
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| 490. | They Just Gave Death Certificate A MASSIVE Upgrade! | 92 | | The Binding of Isaac: Rebirth
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| 491. | Binding Of Isaac, But EVERY Item is Golden. | 84 | | The Binding of Isaac: Rebirth
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| 492. | How The WORST Item In The Game CARRIED The Run | 77 | | The Binding of Isaac: Rebirth
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| 493. | How This NEW CHARACTER Completely Broke Me... | 89 | | The Binding of Isaac: Rebirth
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| 494. | Isaac, But Every Item Is QUALITY4! | 84 | | The Binding of Isaac: Rebirth
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| 495. | I Tried The CREEPIEST Character In Isaac's HISTORY. | 89 | | The Binding of Isaac: Rebirth
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| 496. | Azazel Truly Is THE EASIEST Character In The Game | 80 | | The Binding of Isaac: Rebirth
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| 497. | This NEW Character Is The SEXIEST Strongest I've EVER Tried! | 90 | | The Binding of Isaac: Rebirth
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| 498. | WEAKEST Modded Character In Isaac: | 97 | | The Binding of Isaac: Rebirth
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| 499. | This Run MELTED The Beast | 82 | | The Binding of Isaac: Rebirth
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| 500. | Isaac, But EVERY Second I Get MORE STATS! | 112 | | The Binding of Isaac: Rebirth
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