IsaacGuru is a channel dedicated to showcase items in The Binding of Isaac Repentance and various game mechanics via instructive videos.

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The Binding of Isaac: Rebirth

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Latest Videos

The NEW NEW TARNISHED ISAAC Unlock Cutscene in Epiphany - The Binding of Isaac

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All New SOUND EFFECTS! The Binding of Isaac Repentance+ Update

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All New GOLDEN TRINKET Effects! The Binding of Isaac Repentance+ Update

2025-09-12 11:30:00 PM ● 47,460 views ● 0:00

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Item Buffs, Internal Item Descriptions, New Devil Deals, and More! UPDATE v.1.9.7.13

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The NEW Necromancer Transformation in The Binding of Isaac

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The PERFECT Diplopia - The Binding of Isaac #shorts

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Fruity Rooms - 25 NEW OP ITEMS - The Binding of Isaac Mod Showcase

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Runic Tablet - NEW MOD - The Binding of Isaac Mod Showcase

2025-09-01 5:00:55 PM ● 2,942 views ● 0:00

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The NEW and REWORKED Dimensional Key in The Binding of Isaac Epiphany

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Ankle Weights - NEW ITEM in The Binding of Isaac Epiphany

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