| 2020-07-27 | #272: No IoT things in hand? Simulate them with Device Simulator Express | 51:49 | 677 | Show |
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| 2020-07-08 | #271: Unlock the Mysteries of Time, Python's Datetime That Is! | 1:04:35 | 415 | Show |
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| 2020-06-27 | #269: Holoviz - a Suite of Tools for Python Visualization | 55:59 | 902 | Show |
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| 2020-06-27 | #270: Python in Supply Chains: Oil Rigs, Rockets, and Lettuce | 59:22 | 318 | Show |
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| 2020-06-15 | Course Trailer: Python for Absolute Beginners | 6:39 | 11,515 | |
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| 2020-06-15 | #267: 15 Amazing PyTest Plugins | 53:36 | 965 | Show |
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| 2020-06-14 | #266 - Refactoring Your Code like Magic with Sourcery | 57:08 | 616 | Show |
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| 2020-06-13 | Episode #265: Why is Python slow? | 1:03:29 | 838 | Show |
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| 2020-06-12 | #264 10 tips every Flask developer should know | 1:08:50 | 1,247 | Show |
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| 2020-06-11 | #263 SEO for developers | 1:02:37 | 131 | Show |
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| 2020-06-10 | #262 Build a career in data science | 1:11:18 | 327 | Show |
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| 2020-06-09 | #261 Monitoring and Auditing Machine Learning | 1:00:44 | 140 | Show |
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| 2020-06-08 | #259 From Academia to Tech Industry and Python | 1:00:59 | 144 | Show |
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| 2020-06-08 | #260 From basic script to interactive data sci app with Streamlit | 59:27 | 205 | Show |
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| 2020-06-07 | #257 Exploring the galaxy with the fastest supercomputer, Python, and radio astronomy | 52:25 | 122 | Show |
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| 2020-06-06 | #256 Click to run your notebook with Binder | 57:28 | 89 | Show |
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| 2020-06-05 | #255 Talking to Cars with Python | 51:53 | 136 | Show |
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| 2020-06-04 | #254 a Python Mentorship Story | 1:07:27 | 116 | Show |
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| 2020-06-03 | #253 Moon base geekout | 1:22:49 | 116 | Show |
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| 2020-06-02 | #252 What scientific computing can learn from CS | 1:10:59 | 105 | Show |
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| 2020-06-01 | #251 Building and UX Testing Azure's Python SDK | 52:47 | 86 | Show |
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| 2020-05-31 | #250 Capture over 400x C02 as trees with AI and Python | 1:03:08 | 84 | Show |
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| 2020-05-30 | #249 Capture the Staff of Pythonic Knowledge in TwilioQuest | 59:03 | 685 | Show |
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| 2020-05-29 | #248 Climate Change and Your Python Code | 1:16:37 | 321 | Show |
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| 2020-05-28 | #247 Solo Maintainer of Open Source in Academia | 1:05:22 | 111 | Show |
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| 2020-05-27 | #246 Practices of the Python Pro | 1:04:10 | 727 | Show |
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| 2020-05-26 | #245 Python Packaging Landscape in 2020 | 1:01:56 | 194 | Show |
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| 2020-05-25 | #244 Top 10 Real Python Articles of 2019 | 59:52 | 173 | Show |
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| 2020-05-24 | #243 Python on Windows is OK, actually | 57:41 | 157 | Show |
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| 2020-05-23 | #242 Your Education Will Be Live Streamed | 54:24 | 89 | Show |
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| 2020-05-22 | #241 Opal: Full Stack Health Care Apps | 53:26 | 352 | Show |
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| 2020-05-21 | #240 A Guided Tour of the CPython Source Code | 1:00:28 | 769 | Guide |
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| 2020-05-20 | #239 Bayesian Foundations | 57:20 | 168 | Show |
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| 2020-05-20 | #258 - Thriving in a Remote Developer Environment | 1:07:32 | 89 | Show |
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| 2020-05-19 | #238 Collaborative Data Science with Gigantum | 1:07:19 | 161 | Show |
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| 2020-05-18 | #237 A gut feeling about Python | 49:42 | 185 | Show |
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| 2020-03-18 | #236 Scaling data science across Python and R | 1:00:51 | 444 | Show |
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| 2020-03-17 | #235 Python in your Browser with Skulpt | 1:00:22 | 1,345 | Let's Play |
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| 2020-03-17 | #234 Awesome Python Applications | 1:04:38 | 590 | Show |
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| 2020-03-14 | #233 The Masonite Python Web Framework | 1:08:20 | 1,014 | Show |
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| 2020-03-13 | #232 Become a robot developer with Python | 1:01:36 | 484 | Show |
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| 2020-03-12 | #231: Advice for Freelancing with Python | 1:09:43 | 753 | Show |
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| 2020-03-09 | #230 Python in digital humanities research | 57:45 | 303 | Show |
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| 2020-03-01 | #229: Building Advanced Pythonic Interviews with Docassemble - Talk Python to Me Podcast | 1:00:45 | 456 | Show |
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| 2020-02-29 | #228 Hunting Bugs and Tech Startups with Python - Talk Python to Me Podcast | 59:44 | 194 | Show |
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| 2020-02-28 | #227 Maintainable Data Science: Tips for Non Developers - Talk Python to Me Podcast | 1:10:50 | 195 | Show |
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| 2020-02-27 | #226 Building Flask APIs for Data Scientists - Talk Python to Me Podcast | 1:09:03 | 1,127 | Show |
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| 2020-02-26 | #225 Can Subinterpreters Free Us from Python's Gil | 1:10:41 | 434 | Show |
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| 2020-02-25 | #224: 12 Lessons from 100 Days of Web | 1:08:57 | 345 | Show |
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| 2020-02-24 | #223: Fun and Easy 2D Games with Python | 1:04:01 | 434 | Show |
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| 2020-02-23 | #222: Interactive graphs with Bokeh and Python | 59:22 | 350 | Show |
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| 2019-12-04 | #221: Empowering developers by embedding Python | 1:07:05 | 546 | |
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| 2019-12-01 | #220: Machine Learning in the cloud with Azure ML | 54:45 | 311 | |
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| 2019-12-01 | #219: Take a Python tour of duty at the United States Digital Service | 1:01:36 | 127 | |
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| 2019-12-01 | #218: Serverless Python functions in Azure | 47:58 | 241 | |
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| 2019-12-01 | #217: Notebooks vs data science-enabled scripts | 54:26 | 119 | |
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| 2019-11-02 | Anvil Course: Web apps with nothing but Python (Free) | 8:04 | 4,493 | |
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| 2019-07-02 | Course Trailer: Building data-driven web apps with Flask and SQLAlchemy | 12:11 | 9,819 | |
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| 2019-06-22 | #216: Digging into Visual Studio Code | 53:06 | 819 | |
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| 2019-06-22 | #215: The software powering Talk Python courses and podcast | 1:07:52 | 323 | Show |
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| 2019-06-22 | #214: Dive into CPython 3.8 and beyond | 1:00:22 | 230 | |
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| 2019-06-22 | #213: WebAssembly and CPython | 49:09 | 300 | |
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| 2019-06-22 | #212: Python in Web Assembly with Pyodide | 57:22 | 2,587 | |
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| 2019-06-21 | #211: Classic CS problems in Python | 1:08:47 | 420 | |
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| 2019-06-21 | #210: Making the most out of in-person training | 1:07:21 | 86 | |
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| 2019-06-21 | #209: Inside Python's new governance model | 1:07:26 | 87 | |
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| 2019-06-21 | #208: Packaging, Making the most of PyCon, and more | 1:10:18 | 79 | |
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| 2019-06-21 | #207: Parallelizing computation with Dask | 57:54 | 228 | |
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| 2019-05-02 | #100DaysOfWeb in Python Course Overview | 8:29 | 768 | |
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| 2019-04-14 | #206: Running Django in Production | 51:26 | 412 | |
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| 2019-04-14 | #205: Beginners and Experts Panel | 57:54 | 201 | |
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| 2019-04-14 | #204: StaticFrame, like Pandas but safer | 1:01:17 | 119 | |
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| 2019-04-13 | #203: Beginners and Experts in Software Development | 56:53 | 274 | Show |
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| 2019-04-13 | #202: Building a software business with Python | 59:02 | 455 | |
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| 2019-04-13 | #201: Choosing JupyterHub and Python over MATLAB | 1:03:36 | 136 | |
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| 2019-04-13 | #200: Escaping Excel Hell with Python and Pandas | 1:05:26 | 627 | |
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| 2019-02-21 | #199: Automate all the things with Python at Zapier | 1:04:46 | 1,892 | |
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| 2019-02-21 | #198: Catching up with the Anaconda distribution | 1:05:15 | 122 | |
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| 2019-02-21 | #197: Modern Python Standard Library Cookbook | 1:00:48 | 742 | |
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| 2019-02-21 | #196: Datalore: Hosted smart notebooks | 49:51 | 486 | |
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| 2019-02-21 | #195: Teaching Python at Apple | 1:00:24 | 135 | |
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| 2019-01-18 | #194: Learning (and teaching) Python in a vacuum | 1:06:45 | 370 | |
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| 2019-01-18 | #192: Python Year in Review 2018 Edition | 59:04 | 163 | Review |
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| 2019-01-17 | #193: Data Science Year in Review 2018 Edition | 1:19:52 | 106 | Review |
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| 2019-01-17 | #191: Python's journey at Microsoft | 1:11:41 | 129 | |
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| 2019-01-17 | #190: Teaching Django | 1:01:01 | 274 | |
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| 2019-01-17 | #189: War Stories of the Developer Evangelists | 59:11 | 61 | |
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| 2019-01-15 | Course Trailer: Using and Mastering Cookiecutter | 5:01 | 21,354 | |
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| 2019-01-15 | Consuming HTTP Services in Python course introduction | 3:31 | 780 | |
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| 2019-01-15 | Managing Python Dependencies @ Talk Python course introduction | 3:29 | 89 | |
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| 2019-01-15 | RESTful and HTTP APIs in Pyramid course introduction | 6:39 | 1,389 | |
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| 2019-01-15 | Eve: Building RESTful APIs with MongoDB and Flask course introduction | 4:02 | 2,234 | |
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| 2019-01-15 | Course Trailer: MongoDB for Developers with Python | 10:44 | 6,485 | |
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| 2019-01-15 | MongoDB Quickstart Course Introduction (Free) | 4:33 | 48 | |
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| 2019-01-15 | Python for Entrepreneurs course introduction | 5:26 | 363 | |
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| 2019-01-15 | Introduction to Ansible course summary | 1:44 | 68 | |
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| 2019-01-15 | Python 3, an Illustrated Tour course introduction | 3:37 | 118 | |
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| 2019-01-15 | Mastering PyCharm course introduction | 5:46 | 1,068 | |
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| 2019-01-15 | Course Trailer: #100DaysOfCode in Python | 9:21 | 3,098 | |
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| 2019-01-14 | Python Jumpstart by Building 10 Apps Introduction | 5:38 | 263 | |
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