| 2019-01-14 | #188: Async for the Pythonic web with Sanic | 56:23 | 1,047 | |
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| 2019-01-14 | #187: Secure all the things with HubbleStack | 59:54 | 50 | |
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| 2019-01-14 | #186: 100 Days of Python in a Magical Universe | 1:02:12 | 446 | |
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| 2019-01-14 | #185: Creating a Python 3 Culture at Facebook | 1:07:47 | 43 | |
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| 2019-01-14 | #184: Teaching Python with BBC micro:bit | 1:07:39 | 236 | |
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| 2019-01-10 | #183: Qt for Python | 58:04 | 326 | |
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| 2019-01-10 | #182: Picture Python at Shutterfly | 58:16 | 46 | |
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| 2019-01-10 | #181: 30 amazing Python projects | 51:34 | 1,756 | Show |
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| 2019-01-10 | #180: What's new in Python 3.7 and beyond | 57:27 | 105 | |
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| 2019-01-10 | #179: Python Language Summit 2018 | 50:34 | 74 | |
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| 2019-01-10 | #178: Coverage.py | 1:03:32 | 815 | |
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| 2019-01-10 | #177: Flask goes 1.0 | 1:01:47 | 100 | |
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| 2019-01-10 | #176: The Python Community by the Numbers | 53:29 | 22 | |
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| 2019-01-10 | #175: Teaching Python to network engineers | 55:28 | 168 | |
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| 2019-01-10 | #174: Coming into Python from another Industry (part 2) | 51:07 | 46 | |
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| 2019-01-05 | #173: Coming into Python from another Industry (part 1) | 56:39 | 104 | |
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| 2019-01-05 | #172: Nuitka: A full Python compiler | 1:06:54 | 4,705 | |
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| 2019-01-05 | #171: 1M Jupyter notebooks analyzed | 58:33 | 108 | |
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| 2019-01-05 | #170: Guido van Rossum steps down | 37:56 | 233 | |
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| 2019-01-05 | #169: Becoming a Python content creator | 1:06:41 | 148 | |
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| 2019-01-03 | #168: 10 Python security holes and how to plug them | 1:00:15 | 147 | |
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| 2019-01-03 | #167: Simplifying Python's Async with Trio | 55:42 | 784 | |
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| 2019-01-03 | #166: Continuous delivery with Python | 1:09:01 | 85 | |
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| 2018-12-30 | #165: Python and the blockchain | 1:05:00 | 193 | |
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| 2018-12-30 | #164: Python in Brain Research at the Allen Institute | 57:55 | 118 | |
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| 2018-12-29 | #163: Python in Geoscience | 52:18 | 2,130 | |
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| 2018-12-29 | #161: Django 2.0 | 1:07:12 | 147 | |
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| 2018-12-28 | #160: Lektor: Beautiful websites out of flat files | 55:42 | 935 | |
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| 2018-12-28 | #159: Inside the new PyPI launch | 1:00:40 | 57 | |
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| 2018-12-28 | #158: Quantum Computing and Python | 47:55 | 369 | |
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| 2018-12-28 | #157: The Journal of Open Source Software | 1:04:47 | 61 | |
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| 2018-12-27 | #156: Python History and Perspectives | 59:08 | 89 | |
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| 2018-12-11 | #155: Practical steps for moving to Python 3 | 1:03:27 | 97 | |
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| 2018-12-10 | #154: Python in Biology and Genomics | 58:16 | 2,464 | Vlog |
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| 2018-12-10 | #152: Understanding and using Python's AST | 51:56 | 3,213 | |
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| 2018-12-10 | #151: Gradual Typing of Production Applications | 1:09:01 | 54 | |
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| 2018-12-10 | #153: How Python Evolves | 59:20 | 32 | |
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| 2018-12-09 | #149: 4 Python Web Frameworks, Compared | 56:42 | 565 | |
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| 2018-12-09 | #148: Python Book Authors' Panel Discussion | 1:02:05 | 51 | Discussion |
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| 2018-12-09 | #147: Quart: Flask, but 3x faster | 51:02 | 981 | |
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| 2018-12-03 | #146: Building Alexa Skills with Python and Flask | 1:01:07 | 552 | |
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| 2018-12-03 | #145: 2017 Python Year in Review | 58:41 | 59 | Review |
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| 2018-12-03 | #144: Machine Learning at the Large Hadron Collider | 58:23 | 150 | |
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| 2018-12-03 | #143: Tuning Python Web App Performance | 1:03:24 | 81 | |
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| 2018-12-03 | #142: Automating the web with Selenium and InstaPy | 1:01:00 | 617 | |
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| 2018-11-30 | #141: Python tricks | 1:11:09 | 309 | |
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| 2018-11-30 | #140: Level up your Python with #100DaysOfCode challenge | 57:43 | 726 | |
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| 2018-11-30 | #139: Paths into a data science career | 1:02:15 | 132 | |
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| 2018-11-30 | #138: Anvil: All web, all Python | 1:00:13 | 572 | |
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| 2018-11-30 | #137: Design concepts and tips for developers | 57:36 | 54 | |
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| 2018-11-29 | #136: Secure code lessons from Have I Been Pwned | 1:00:19 | 55 | |
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| 2018-11-29 | #135: Capturing human moments with AI and Python | 54:10 | 64 | |
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| 2018-11-29 | #134: Python in Climate Science | 52:50 | 422 | |
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| 2018-11-29 | #133: Productivity for developers | 1:04:30 | 59 | Show |
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| 2018-11-27 | #132: Contributing to open source | 1:04:45 | 76 | |
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| 2018-11-26 | #131: Top 10 machine learning libraries | 53:31 | 100 | |
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| 2018-11-25 | #130: 10 books Python developers should be reading | 51:54 | 124 | |
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| 2018-11-25 | #129: Falcon: The bare-metal Python web framework | 59:54 | 2,503 | |
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| 2018-11-25 | #128: Pythonic Networks with NAPALM | 56:22 | 181 | |
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| 2018-11-25 | #127: Shipping software to users | 1:15:11 | 57 | |
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| 2018-11-19 | #126: Kubernetes for Pythonistas | 59:40 | 87 | |
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| 2018-11-19 | #125: Django REST framework and a new API star is born | 1:07:18 | 224 | |
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| 2018-11-19 | #124: Python for AI research | 55:21 | 63 | |
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| 2018-11-19 | #123: Lessons from 100 straight dev job interviews | 46:24 | 55 | |
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| 2018-11-19 | #122: Home Assistant: Pythonic Home Automation | 58:09 | 683 | |
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| 2018-11-18 | #121: Microservices in Python | 1:05:14 | 333 | |
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| 2018-11-18 | #120: Python in Finance | 1:07:42 | 336 | |
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| 2018-11-18 | #119: Python in Engineering | 52:24 | 129 | |
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| 2018-11-18 | #118: Serverless software | 54:51 | 24 | |
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| 2018-11-18 | #117: Functional Python with Coconut | 1:03:32 | 596 | |
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| 2018-11-14 | #116: 10 top talks of PyCon 2017 reviewed | 1:00:19 | 73 | Review |
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| 2018-11-14 | #115: Python for Humans projects | 53:46 | 85 | |
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| 2018-11-14 | #114: Empowering developers at the Hidden Genius project | 38:03 | 21 | |
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| 2018-11-14 | #113: Dedicated AI chips and running old Python faster at Intel | 53:03 | 50 | |
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| 2018-11-14 | #112: Geeking out in the golden years | 1:07:16 | 28 | |
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| 2018-11-09 | #111: Pythonic Career Advice and More | 57:06 | 126 | |
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| 2018-11-09 | #110: Data Democratization with Redash | 56:02 | 2,708 | |
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| 2018-11-09 | #109: MongoDB Applied Design Patterns | 1:00:25 | 327 | |
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| 2018-11-09 | #108: MicroPython and Open Source Hardware at Adafruit | 1:04:44 | 116 | |
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| 2018-11-09 | #107: Python concurrency with Curio | 1:01:20 | 873 | |
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| 2018-11-04 | Course Trailer: Async Techniques and Examples in Python | 5:22 | 3,814 | |
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| 2018-11-02 | #106: Invent your own computer games with Python | 58:13 | 1,645 | |
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| 2018-11-02 | #105: A Pythonic Database Tour | 57:57 | 116 | |
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| 2018-11-02 | #104: Game Theory in Python | 57:51 | 1,890 | |
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| 2018-11-01 | #103: Compiling Python through PyLLVM and MongoDB for Data Scientists | 52:37 | 81 | |
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| 2018-10-31 | #102: Effective Code Reviews | 50:53 | 63 | Review |
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| 2018-10-31 | #101: Adding a full featured Python environment to Visual Studio Code | 55:12 | 310 | |
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| 2018-10-31 | #100: Python past, present, and future with Guido van Rossum | 1:01:49 | 702 | Show |
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| 2018-10-31 | #99: Morepath: Super Powered Python Web Framework | 1:04:53 | 154 | |
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| 2018-10-31 | #98: Adding concurrency to Django with Django Channels | 1:05:15 | 380 | |
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| 2018-10-31 | #97: Flask, Django style with Flask-Diamond | 1:05:04 | 97 | |
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| 2018-10-30 | #96: Exploring Awesome Python | 52:21 | 108 | |
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| 2018-10-30 | #95: Grumpy: Running Python on Go | 52:10 | 526 | |
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| 2018-10-30 | #94: Guaranteed packages via Conda and Conda-Forge | 46:30 | 428 | |
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| 2018-10-30 | #93: Spreading Python through the sciences with Software Carpentry | 1:01:38 | 23 | |
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| 2018-10-30 | #92:Python Bytes Crossover: Python 3.6 is going to be awesome, | 21:01 | 40 | Show |
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| 2018-10-25 | #91: Top 10 Data Science Stories of 2016 | 1:07:38 | 74 | Show |
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| 2018-10-25 | #90: Data Wrangling with Python | 1:01:36 | 1,140 | |
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| 2018-10-25 | #89: A conversation with the Chief Data Scientist of the United States | 52:40 | 53 | |
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| 2018-10-24 | #88: Lightweight Django | 59:58 | 203 | |
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