| 401. | This New Character Can Create Familiars! Tainted Siren Gameplay! | 0:00 | | The Binding of Isaac: Rebirth
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| 402. | This New Silver Crown Gave Me Infinite Stats! | 0:00 | | The Binding of Isaac: Rebirth
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| 403. | The Luckiest Isaac Run I've Ever Had! | 0:00 | | The Binding of Isaac: Rebirth
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| 404. | They Made Delirious Isaac. He's literally BROKEN! | 0:00 | | The Binding of Isaac: Rebirth
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| 405. | Isaac, But Every Time I Die I Get More Stats! | 0:00 | | The Binding of Isaac: Rebirth
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| 406. | I Found The Most Broken Room In Isaac History! | 0:00 | | The Binding of Isaac: Rebirth
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| 407. | I Finally Got ALL Achievements In Isaac And It's INSANE! | 0:00 | | The Binding of Isaac: Rebirth
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| 408. | This New Item Is Better Than Homing! Isaac With Aimbot! | 0:00 | | The Binding of Isaac: Rebirth
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| 409. | This New Keeper Challenge Is Extremely Hard! | 0:00 | | The Binding of Isaac: Rebirth
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| 410. | They Turned Slot Machine Into A Character?! It's INSANE! | 0:00 | | The Binding of Isaac: Rebirth
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| 411. | They Added A New Spider Character! It's Extremely Cute! | 0:00 | | The Binding of Isaac: Rebirth
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| 412. | This New Cyborg Transformation Is Literally BROKEN! | 0:00 | | The Binding of Isaac: Rebirth
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| 413. | Tainted Sin Is Extremely Broken! (0.01% Gamebreak) | 0:00 | | The Binding of Isaac: Rebirth
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| 414. | Isaac, But He Has Finally Grown Up! | 0:00 | | The Binding of Isaac: Rebirth
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| 415. | Playable Blood Donation Machine Is Too Horrifying! | 0:00 | | The Binding of Isaac: Rebirth
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| 416. | I Opened Every Single Room In Isaac With This New Item! | 0:00 | | The Binding of Isaac: Rebirth
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| 417. | This New Satan's Contract Gave Me Unlimited Power! | 0:00 | | The Binding of Isaac: Rebirth
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| 418. | I Faced The Hardest Secret Boss In Isaac History! | 0:00 | | The Binding of Isaac: Rebirth
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| 419. | Adding This Sawblade To Isaac Was A Mistake... | 0:00 | | The Binding of Isaac: Rebirth
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| 420. | Playing New Pure Isaac Is Extremely Fun! | 0:00 | | The Binding of Isaac: Rebirth
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| 421. | I Found A New Ultra Rare Isaac Miniboss! | 0:00 | | The Binding of Isaac: Rebirth
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| 422. | This New Item Turns Everything Into GOLD! | 0:00 | | The Binding of Isaac: Rebirth
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| 423. | This Is Why I Rig Every Run In Isaac! | 0:00 | | The Binding of Isaac: Rebirth
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| 424. | Isaac Run, But Every Item Is A Golden Horse Pill... | 0:00 | | The Binding of Isaac: Rebirth
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| 425. | These New Alternative Final Bosses Are Crazy Hard! | 0:00 | | The Binding of Isaac: Rebirth
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| 426. | Isaac Run, But Every Room I Get A New Character! | 0:00 | | The Binding of Isaac: Rebirth
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| 427. | I Played The Most Unpleasant Isaac Challenge Ever... | 0:00 | | The Binding of Isaac: Rebirth
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| 428. | These New Isaac Unlocks Are INSANE! | 0:00 | | The Binding of Isaac: Rebirth
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| 429. | Can I Survive With Isaac's Heart As Tainted Lost? | 0:00 | | The Binding of Isaac: Rebirth
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| 430. | Isaac Online Is Finally Out! Getting New Achievements & More! | 0:00 | | The Binding of Isaac: Rebirth
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| 431. | This New Candle Transformation Is Absolutely Incredible! | 0:00 | | The Binding of Isaac: Rebirth
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| 432. | This New Character Can Spawn Army Of Zombies! | 0:00 | | The Binding of Isaac: Rebirth
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| 433. | I Broke World Record And Became The Richest Isaac Player! | 0:00 | | The Binding of Isaac: Rebirth
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| 434. | This New Alternative Floor Changed EVERYTHING! | 0:00 | | The Binding of Isaac: Rebirth
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| 435. | This New Character Can Create Isaac Army! | 0:00 | | The Binding of Isaac: Rebirth
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| 436. | This New Item Gave Me Insane Damage! | 0:00 | | The Binding of Isaac: Rebirth
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| 437. | This New Item Turns Isaac Into Scariest Demonic Creature! | 0:00 | | The Binding of Isaac: Rebirth
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| 438. | I Found The Best Familiar In The Game! It's CRAZY! | 0:00 | | The Binding of Isaac: Rebirth
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| 439. | This New Item Turns Isaac Into Scariest Boss! | 0:00 | | The Binding of Isaac: Rebirth
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| 440. | I Created My Own Immortal Mini Isaac Army! | 0:00 | | The Binding of Isaac: Rebirth
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| 441. | I Found The Easiest Way To Get Into All Rooms In Isaac! | 0:00 | | The Binding of Isaac: Rebirth
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