| 301. | This New Challenge Will Make You Scream! Epiphany Challenge #4 | 15:22 | | The Binding of Isaac: Rebirth
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| 302. | Tainted Eden Run, But It's 100 Times More Random! | 15:20 | | The Binding of Isaac: Rebirth
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| 303. | How Can I Survive This?! Insane Bomb Custom Challenge! | 15:19 | | The Binding of Isaac: Rebirth
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| 304. | They Really Added Naruto In Isaac?! Epiphany Challenge #1 | 15:17 | | The Binding of Isaac: Rebirth
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| 305. | 300 DMG??? Tainted Keeper's Explosive Run! | 15:15 | | The Binding of Isaac: Rebirth
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| 306. | How I Abused Magic Skin?! Eden to Delirium Cursed Run! | 15:14 | | The Binding of Isaac: Rebirth
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| 307. | This Reworked First Page Is Insane! Playing As 4 Characters At Once! | 15:12 | | The Binding of Isaac: Rebirth
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| 308. | I'll never get this lucky again! Tainted keeper free win start (gone wrong) | 15:11 | | The Binding of Isaac: Rebirth
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| 309. | 100 LUCK RUN!!! Tainted Lost to Mother #9 | 15:10 | | The Binding of Isaac: Rebirth
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| 310. | I Think I Got The Rarest Drop In Isaac... | 15:08 | | The Binding of Isaac: Rebirth
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| 311. | The Biggest Damage Multiplier So Far! The Lost Deals Real Damage! | 15:07 | | The Binding of Isaac: Rebirth
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| 312. | They Made A Challenge For Tarnished Lost?! Epiphany Challenge #9 | 15:04 | | The Binding of Isaac: Rebirth
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| 313. | This New Upgradable Familiar Is Amazing! Retribution Challenge #4 | 15:04 | | The Binding of Isaac: Rebirth
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| 314. | DOUBLE DEATH CERTIFICATE! Luckiest Tainted Samson Run Ever! | 15:04 | | The Binding of Isaac: Rebirth
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| 315. | The Bloodiest Character In The Game! Tarnished Maggy Gameplay! | 15:01 | | The Binding of Isaac: Rebirth
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| 316. | The Razor Queen! Eve to Mother | 15:00 | | The Binding of Isaac: Rebirth
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| 317. | I Finally Unlocked Tarnished Keeper! The Luckiest 120 Fire Rate Greedier! | 15:00 | | The Binding of Isaac: Rebirth
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| 318. | The Hardest Character Ever Made? Fiend Folio Challenge #1 | 14:58 | | The Binding of Isaac: Rebirth
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| 319. | I Completely Broke This New Isaac Challenge! Epiphany Challenge #5 | 14:50 | | The Binding of Isaac: Rebirth
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| 320. | HUGE SWORD! Tainted Lilith mega insane run! | 14:48 | | The Binding of Isaac: Rebirth
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| 321. | Lamb Speedrun, But I Have Only 1 Item! | 14:47 | | The Binding of Isaac: Rebirth
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| 322. | Blue flamethrower! Tainted Lost to Mother #3 | 14:38 | | The Binding of Isaac: Rebirth
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| 323. | I Played The Hardest Isaac Challenge Ever... | 14:38 | | The Binding of Isaac: Rebirth
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| 324. | What Happens If I Take Every Technology Item In The Game?! | 14:36 | Vlog | The Binding of Isaac: Rebirth
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| 325. | Best Ludovico Synergy? Cain to Mother | 14:35 | | The Binding of Isaac: Rebirth
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| 326. | Is this combo actually good? Cain to Satan | 14:34 | | The Binding of Isaac: Rebirth
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| 327. | What can I get? Tainted Azazel chaos start! | 14:31 | | The Binding of Isaac: Rebirth
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| 328. | I Got 2 Bricks Instead Of Tears?! Fiend Folio Challenge #6 | 14:22 | | The Binding of Isaac: Rebirth
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| 329. | Can I Survive With 50 Enemies In The Room?! Fiend Folio challenge #7 | 14:15 | | The Binding of Isaac: Rebirth
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| 330. | The Most Fragile Character In The Game!? Fiend Folio Challenge #4 | 14:15 | | The Binding of Isaac: Rebirth
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| 331. | Planetarium Start! Tainted Lost 1% Run! | 14:15 | | The Binding of Isaac: Rebirth
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| 332. | This New Demon Beggar Gives The Best Items! Retribution Challenge #3 | 14:13 | | The Binding of Isaac: Rebirth
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| 333. | How To 1 Shot Every Boss In The Game! Lost's Double Fire Run! | 14:12 | Guide | The Binding of Isaac: Rebirth
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| 334. | Triple Homing Rainbow Brimstone! Flipping with Eden! | 14:09 | | Brimstone
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| 335. | Tainted Lost to Beast: ELECTRO RAVE | 14:08 | | The Binding of Isaac: Rebirth
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| 336. | How I Got 25 Damage Multiplier? Tainted Isaac Godlike Run! | 14:07 | | The Binding of Isaac: Rebirth
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| 337. | Can Tarnished Cain Win Without His Bag?! Epiphany Challenge #3 | 14:04 | | The Binding of Isaac: Rebirth
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| 338. | The Rarest Chest Drop In Repentance! Ultra Lucky Tainted Lost! | 14:03 | | The Binding of Isaac: Rebirth
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| 339. | What Happens If 11 Tarnished Judases Fight Ultra Greed?! | 13:53 | | The Binding of Isaac: Rebirth
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| 340. | This Is The Craziest Tarnished Character Ever! Tarnished Samson Unlock! | 13:51 | | The Binding of Isaac: Rebirth
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| 341. | How To Melt Enemies Guide! Tainted Eve's Holy Run! | 13:49 | Guide | The Binding of Isaac: Rebirth
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| 342. | Sacred Heart Start!!! The Luckiest Chaos Ever! | 13:45 | | The Binding of Isaac: Rebirth
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| 343. | GOODBYE BITRATE! Tainted Isaac PC-breaking run! | 13:44 | | The Binding of Isaac: Rebirth
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| 344. | This Is Too Random For Me... Eden Reroll Madness! | 13:36 | | The Binding of Isaac: Rebirth
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| 345. | Binding Of Isaac, But I Can Only Jump To WIn | 13:32 | | The Binding of Isaac: Rebirth
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| 346. | This New Character Has All The Tear Effects! Retribution Challenge #8 | 13:30 | | The Binding of Isaac: Rebirth
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| 347. | Can I Survive Without Shooting Tears?! Retribution Challenge #6 | 13:30 | | The Binding of Isaac: Rebirth
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| 348. | Tainted Lost Tmtrainer Experience... Custom Challenge Gone Wrong | 13:25 | | The Binding of Isaac: Rebirth
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| 349. | Incredible DMG boost! Tainted Lost to Mother #2 | 13:22 | | The Binding of Isaac: Rebirth
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| 350. | I Just Unlocked Tarnished Lost And It's INSANE! | 13:20 | | The Binding of Isaac: Rebirth
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| 351. | These Hands Won't Let Me Go! Fiend Folio Bonus Challenge! | 13:17 | | The Binding of Isaac: Rebirth
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| 352. | I Got The Most Powerful Bag Synergy Ever! | 13:16 | | The Binding of Isaac: Rebirth
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| 353. | ONE ITEM WIN - LEMEGETON! Tainted Lost to Mother #7 | 13:09 | | The Binding of Isaac: Rebirth
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| 354. | Rainbow Technology! Eden Crazy Disco Run! | 13:08 | Vlog | The Binding of Isaac: Rebirth
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| 355. | Isaac Run, But Every Enemy Has Homing! | 13:06 | | The Binding of Isaac: Rebirth
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| 356. | Another Tarnished Character Is Here! How To Unlock Tarnished Maggy? | 13:02 | Guide | The Binding of Isaac: Rebirth
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| 357. | New Way Of Unlocking Tarnished Isaac Is Too Horrifying! | 13:00 | | The Binding of Isaac: Rebirth
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| 358. | YouTuber Luck! Wombo Combo With Tainted Judas! | 12:56 | | The Binding of Isaac: Rebirth
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| 359. | This is getting too tough... Tainted Lost to Mother (behind the scenes) | 12:55 | | The Binding of Isaac: Rebirth
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| 360. | This New Challenge Turned Me Into A God! Epiphany Challenge #8 | 12:49 | | The Binding of Isaac: Rebirth
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| 361. | This New Item Turns Isaac Into A Cthulhu! | 12:42 | | The Binding of Isaac: Rebirth
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| 362. | This New Book Gives You Infinite Damage! | 12:41 | | The Binding of Isaac: Rebirth
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| 363. | Don't eat cookies with milk! Tainted Keeper rainbow run! | 12:39 | | The Binding of Isaac: Rebirth
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| 364. | I Finally Unlocked Tarnished Cain! (The New Way) | 12:37 | | The Binding of Isaac: Rebirth
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| 365. | Damocles Mongo Gang! Tainted Lost to Mother #4 | 12:35 | | The Binding of Isaac: Rebirth
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| 366. | This Makes Tarnished Eden Even More Random?! Epiphany Challenge #2 | 12:29 | | The Binding of Isaac: Rebirth
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| 367. | The Luckiest Challenge I've Ever Had! Fiend Folio Challenge #10 | 12:29 | | The Binding of Isaac: Rebirth
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| 368. | This New Cube Turnes Enemies Into Items!? Epiphany Challenge #7 | 12:20 | | The Binding of Isaac: Rebirth
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| 369. | This New Character Is Too Overpowered! Samael Gameplay! | 12:12 | | The Binding of Isaac: Rebirth
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| 370. | Angel Or Devil? The Balance of Tainted Azazel! | 12:05 | | The Binding of Isaac: Rebirth
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| 371. | A Wrong Choice? Lilith's Glitched (Cursed) Crown! | 11:57 | | The Binding of Isaac: Rebirth
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| 372. | Satisfying brimstone! Judas to Lamb | 11:44 | | The Binding of Isaac: Rebirth
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| 373. | Brimstone is getting out of control!!! Tainted Lost to Mother #1 | 11:40 | | The Binding of Isaac: Rebirth
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| 374. | INFINITE REROLLS? Tainted Bethany madness! | 11:35 | | The Binding of Isaac: Rebirth
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| 375. | Void Or Abyss? First Run In New Repentance Patch! | 11:33 | | The Binding of Isaac: Rebirth
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| 376. | Playable Peter Griffin In Fiend Folio! Impossible To Win! | 10:59 | | The Binding of Isaac: Rebirth
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| 377. | I Played The Weirdest Challenge In Isaac... | 10:43 | | The Binding of Isaac: Rebirth
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| 378. | I Played The Hardest Isaac Challenge Ever Created! | 10:27 | | The Binding of Isaac: Rebirth
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| 379. | I Finally Got The Most Random Character In The Game! Tarnished Eden Unlock! | 9:16 | | The Binding of Isaac: Rebirth
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| 380. | This Item Allows You Go Through The Walls! Fiend Folio Challenge #12 | 6:39 | | The Binding of Isaac: Rebirth
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| 381. | Apollyon To Mega Satan Speedrun! (No Seed) | 6:29 | | The Binding of Isaac: Rebirth
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| 382. | Waiting for Tarnished Lost to release be like: #shorts | 0:26 | | The Binding of Isaac: Rebirth
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| 383. | This New Item Gives You Super Homing Tears! | 0:00 | |
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| 384. | I Broke World Record And Became The Richest Isaac Player! | 0:00 | | The Binding of Isaac: Rebirth
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| 385. | What Happens If I Void Every Active Item In The Game?! | 0:00 | |
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| 386. | The Craziest Character I've Ever Played! Tainted Zoe Gameplay! | 0:00 | |
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| 387. | How I Shot Giant Rockets As Tainted Lost! | 0:00 | |
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| 388. | This New Dice Literally Broke My Game! | 0:00 | | The Binding of Isaac
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| 389. | These New Isaac Unlocks Are INSANE! | 0:00 | | The Binding of Isaac: Rebirth
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| 390. | Isaac Online Is Finally Out! Getting New Achievements & More! | 0:00 | | The Binding of Isaac: Rebirth
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| 391. | I Found A New Ultra Rare Isaac Miniboss! | 0:00 | | The Binding of Isaac: Rebirth
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| 392. | Alcoholic Catgirl Is Ridiculously Drunk! | 0:00 | |
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| 393. | I Tried The Most Intense Challenge In Isaac History... | 0:00 | | The Binding of Isaac: Rebirth
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| 394. | This New Dice Completely Broke My Game! | 0:00 | |
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| 395. | Isaac Run, But Every Item Is A Golden Horse Pill... | 0:00 | | The Binding of Isaac: Rebirth
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| 396. | Money=Power Got A Huge Upgrade! It Gives Insane Damage! | 0:00 | |
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| 397. | I Opened Every Single Room In Isaac With This New Item! | 0:00 | | The Binding of Isaac: Rebirth
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| 398. | These New Alternative Final Bosses Are Crazy Hard! | 0:00 | | The Binding of Isaac: Rebirth
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| 399. | Tainted Adam Is Finally Out! He's Extremely BROKEN! | 0:00 | |
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| 400. | This Trinket Adds Unique Effects For Every Character! | 0:00 | |
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