| 1. | This Devil Deal Literally Broke My Game! | 77 | |
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| 2. | I Found The Best Familiar In The Game! It's CRAZY! | 93 | | The Binding of Isaac: Rebirth
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| 3. | This Crazy Glitch Almost Ruined My Run! | 40 | |
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| 4. | I Faced The Hardest Secret Boss In Isaac History! | 133 | | The Binding of Isaac: Rebirth
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| 5. | This New Secret Isaac Character Is Extremely Glitched! | 72 | | The Binding of Isaac: Rebirth
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| 6. | They Added Red Hush To The Game! It's INSANE! | 136 | |
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| 7. | Isaac, But Every Time I Die I Get More Stats! | 62 | | The Binding of Isaac: Rebirth
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| 8. | They Made Playable Duke Of Flies! It's Extremely Cute! | 120 | |
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| 9. | I Created My Own Immortal Mini Isaac Army! | 94 | | The Binding of Isaac: Rebirth
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| 10. | They Turned Crane Game Into A Character! It's BROKEN! | 183 | |
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| 11. | I Found A New Ultra Rare Isaac Miniboss! | 119 | | The Binding of Isaac: Rebirth
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| 12. | This New Character Has The Most Powerful Abilities! | 88 | |
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| 13. | This New Dice Literally Broke My Game! | 70 | | The Binding of Isaac
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| 14. | The Craziest Character Ever Made! Tarnished Blue Baby Gameplay! | 93 | |
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| 15. | Tainted Sin Is Extremely Broken! (0.01% Gamebreak) | 107 | | The Binding of Isaac: Rebirth
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| 16. | I Opened Every Single Room In Isaac With This New Item! | 274 | | The Binding of Isaac: Rebirth
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| 17. | This New Item Literally Broke My Game! | 104 | |
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| 18. | This New Dice Completely Broke My Game! | 113 | |
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| 19. | I Got The Craziest Rerolls With This New Dice! | 55 | |
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| 20. | I Played As The Tiniest Character In Isaac! | 77 | |
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| 21. | This New Item Is Better Than Homing! Isaac With Aimbot! | 117 | | The Binding of Isaac: Rebirth
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| 22. | I Finally Found New D6! It's Too Evil... | 80 | |
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| 23. | Playable Fortune Telling Machine Is Hilarious! | 154 | |
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| 24. | This Trinket Adds Unique Effects For Every Character! | 113 | |
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| 25. | Playable Blood Donation Machine Is Too Horrifying! | 553 | | The Binding of Isaac: Rebirth
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| 26. | This New Item Gives You Craziest Devil Rooms! | 65 | |
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| 27. | These New Alternative Minibosses Are CRAZY! | 337 | |
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| 28. | They Added A New Spider Character! It's Extremely Cute! | 120 | | The Binding of Isaac: Rebirth
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| 29. | This New Crooked Penny Is Too Risky... | 97 | |
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| 30. | THIS Will Give You Every Angel Item In The Game! | 122 | |
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| 31. | They Turned Slot Machine Into A Character?! It's INSANE! | 154 | | The Binding of Isaac: Rebirth
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| 32. | I Tried Best Multishot Item In The Game! It's CRAZY! | 86 | |
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| 33. | This Secret Isaac Challenge WIll Blow Your Mind! | 145 | | The Binding of Isaac: Rebirth
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| 34. | This New Samael's Weapon Has The Craziest Synergies! | 177 | |
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| 35. | This New Pill Gives You CRAZY Damage! | 143 | |
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| 36. | I Got The Best Familiar Upgrade EVER! | 142 | | The Binding of Isaac: Rebirth
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| 37. | This New Damocles Sword Is Extremely Risky... | 231 | | Damocles
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| 38. | This New Character Gets The WORST Items Only! Tainted Bandit Gameplay! | 114 | | Bandits
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| 39. | This New Godhead Is Absolutely Broken! | 78 | |
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| 40. | I Played The Most Violent Isaac Challenge! | 106 | |
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| 41. | They Turned The Entire Solar System Into A Character! It's INSANE! | 243 | |
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| 42. | These Alternative Horsemen Bosses Are Extremely Hard! | 109 | |
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| 43. | This New Technology Item Almost Crashed My Game! | 101 | |
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| 44. | This New Cursed Room Gave Me The Best Items! | 115 | |
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| 45. | I Got The Luckiest Upgrade In Isaac History! | 61 | |
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| 46. | I Tried The Most Broken Character In Isaac History... | 56 | | The Binding of Isaac: Rebirth
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| 47. | This New Item Gave Me The Most Chaotic Tears Ever! | 122 | |
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| 48. | Isaac, But He Has Finally Grown Up! | 122 | | The Binding of Isaac: Rebirth
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| 49. | This New Tainted Character Is Extremely Hard... | 164 | |
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| 50. | This New Item Makes Everything Literally BROKEN! | 32 | | The Binding of Isaac: Rebirth
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| 51. | The Craziest Character I've Ever Played! Tainted Zoe Gameplay! | 126 | |
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| 52. | I Finally Played As Pure Judas! He's Completely BROKEN! | 293 | |
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| 53. | This New Keeper Challenge Is Extremely Hard! | 161 | | The Binding of Isaac: Rebirth
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| 54. | This New Quality 4 Item Gives INSANE Damage! | 139 | |
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| 55. | This New Lilith Has Insane LUCK! | 119 | |
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| 56. | Alcoholic Catgirl Is Ridiculously Drunk! | 140 | |
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| 57. | New Reworked Tarnished Judas Is INSANE! | 160 | |
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| 58. | This New Golden Keeper Is Extremely Greedy! | 124 | |
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| 59. | I Tried The Riskiest Item In Isaac! It's INSANE! | 80 | | The Binding of Isaac: Rebirth
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| 60. | I Found New Broken Godhead! It's INSANE! | 109 | |
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| 61. | The Hardest Character Ever Made! Tainted Xaphan Gameplay! | 161 | |
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| 62. | These New Alternative Final Bosses Are Crazy Hard! | 125 | | The Binding of Isaac: Rebirth
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| 63. | This New Secret Miniboss Is Too Horrifying! | 175 | |
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| 64. | This New Quality 4 Gives You The Best Items In The Game! | 141 | |
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| 65. | This New Character Has Craziest Synergies! | 71 | |
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| 66. | This New Character Has The Craziest Synergies! | 96 | |
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| 67. | New Final Boss And New Ending! Unlocking Secret Character In Isaac! | 262 | | The Binding of Isaac: Rebirth
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| 68. | I Broke World Record And Became The Richest Isaac Player! | 113 | | The Binding of Isaac: Rebirth
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| 69. | They Added New Devil Sacred Heart?! It's INSANE! | 152 | |
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| 70. | This New Quality 4 Item Has INSANE Synergies! | 452 | | The Binding of Isaac: Rebirth
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| 71. | Isaac Online Is Finally Out! Getting New Achievements & More! | 92 | | The Binding of Isaac: Rebirth
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| 72. | This New Character Has Completely NEW Angel Rooms! Elohim Gameplay! | 119 | |
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| 73. | This New Glitched Dice Almost Broke My Game! | 47 | |
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| 74. | The Luckiest Isaac Run I've Ever Had! | 77 | | The Binding of Isaac: Rebirth
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| 75. | This New Item Gives You Super Homing Tears! | 180 | |
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| 76. | Isaac Will Never Be The Same Again... | 100 | | The Binding of Isaac: Rebirth
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| 77. | Adding This Sawblade To Isaac Was A Mistake... | 173 | | The Binding of Isaac: Rebirth
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| 78. | Money=Power Got A Huge Upgrade! It Gives Insane Damage! | 84 | |
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| 79. | This New Secret Ending Is Insane! | 201 | |
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| 80. | Isaac, But He's Addicted To 'Sugar'... | 122 | | The Binding of Isaac: Rebirth
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| 81. | These New Isaac Unlocks Are INSANE! | 158 | | The Binding of Isaac: Rebirth
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| 82. | This New Character Can Enchant Cards! Joseph Gameplay! | 62 | |
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| 83. | This Is Why I Rig Every Run In Isaac! | 67 | | The Binding of Isaac: Rebirth
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| 84. | I Finally Found The Perfect Gambling Character! | 78 | |
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| 85. | This New Character Gets Stats For Every Kill! | 124 | |
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| 86. | Isaac Run, But Every Item Is A Golden Horse Pill... | 217 | | The Binding of Isaac: Rebirth
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| 87. | These New Angel Bosses Are Insanely HARD! | 87 | | The Binding of Isaac: Rebirth
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| 88. | This New Item Allows You To Visit Unique Planetariums! | 68 | |
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| 89. | They Added Playable Confessional! It's INCREDIBLE! | 278 | |
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| 90. | These New Akeldama Synergies Are Absolutely BROKEN! | 123 | |
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| 91. | This New Item Has The Craziest Synergies! | 109 | |
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| 92. | I Finally Tried Spinup Dice! It's Even More Broken! | 94 | |
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| 93. | The Most Broken Character Ever Made! Bandit Gameplay! | 95 | | Bandits
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| 94. | This New C Section Is Literally BROKEN! | 82 | |
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| 95. | This New Upgraded Sacred Orb Is INSANE! | 110 | |
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| 96. | How I Killed Delirium In Literally One Frame! | 46 | | The Binding of Isaac: Rebirth
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| 97. | They made 20/20, But It's Way Cooler! | 149 | |
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| 98. | This New Character Is INSANELY Rich! | 122 | |
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| 99. | These New Greedier Bosses Are Absolutely Incredible! | 108 | |
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| 100. | This New Item Literally Destroyed My Shops! | 88 | |
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