| 301. | This New Item Instantly Breaks The Game! | 88 | | The Binding of Isaac: Rebirth
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| 302. | This New Demon Character Is INSANE! David Gameplay! | 92 | | The Binding of Isaac: Rebirth
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| 303. | They Made Playable Siren Boss! It's INSANE! | 94 | | The Binding of Isaac: Rebirth
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| 304. | This New Item Turns You Into Dogma Boss! | 141 | | The Binding of Isaac: Rebirth
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| 305. | This New Map Item Creates Impossible Rooms! | 144 | | The Binding of Isaac: Rebirth
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| 306. | This New Character Is Too Overpowered! Samael Gameplay! | 82 | | The Binding of Isaac: Rebirth
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| 307. | I Finally Unlocked Tarnished Keeper! The Luckiest 120 Fire Rate Greedier! | 82 | | The Binding of Isaac: Rebirth
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| 308. | This New Upgradable Familiar Is Amazing! Retribution Challenge #4 | 88 | | The Binding of Isaac: Rebirth
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| 309. | This New Characters Controls Flies! The Hollow Gameplay! | 93 | | The Binding of Isaac: Rebirth
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| 310. | This New Item Gives You Infinite Stats! | 99 | | The Binding of Isaac: Rebirth
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| 311. | You Need Only 2 Items To Win! Cain's Risky Run! | 84 | | The Binding of Isaac: Rebirth
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| 312. | I Unlocked The Craziest Tainted Character In The Game... | 96 | | The Binding of Isaac: Rebirth
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| 313. | They Added New Portals To Isaac. It's Amazing! | 97 | | The Binding of Isaac: Rebirth
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| 314. | This New Character Has The Craziest Tears! | 97 | | The Binding of Isaac: Rebirth
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| 315. | This New Tainted Soy Milk Just Broke My Brimstone! | 85 | | The Binding of Isaac: Rebirth
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| 316. | I Got The Cheapest Gamebreak In Isaac History! | 93 | | The Binding of Isaac: Rebirth
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| 317. | This New Character Has Cursed Damocles! | 93 | | The Binding of Isaac: Rebirth
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| 318. | This Penny Dupes Everything With 100% Chance! Broken Tainted Azazel Run! | 87 | | The Binding of Isaac: Rebirth
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| 319. | I Played The Weirdest Challenge In Isaac... | 89 | | The Binding of Isaac: Rebirth
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| 320. | I Got The Best Items For Tarnished Judas! 11 Shadows Madness! | 87 | | The Binding of Isaac: Rebirth
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| 321. | This New Character Almost Broke My Game! Reap And Tear Gameplay! | 105 | | The Binding of Isaac: Rebirth
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| 322. | This New Item Turns Isaac Into A Cthulhu! | 99 | | The Binding of Isaac: Rebirth
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| 323. | I Finally Got My Luckiest Tainted Keeper Run Ever! | 100 | | The Binding of Isaac: Rebirth
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| 324. | How I Got 25 Damage Multiplier? Tainted Isaac Godlike Run! | 89 | | The Binding of Isaac: Rebirth
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| 325. | What Happens If Samael Takes Every Angel Item In The Game?! | 93 | | The Binding of Isaac: Rebirth
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| 326. | The Luckiest Death Certificate Start!!! (ft. Delirium x3 + Beast speedrun) | 91 | | The Binding of Isaac: Rebirth
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| 327. | Tainted Guppy Looks Completely Baked... | 129 | | The Binding of Isaac: Rebirth
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| 328. | This New Mod Changes Every Boss In The Game! | 124 | | The Binding of Isaac: Rebirth
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| 329. | Tainted David's Abilities Are Too Broken! | 114 | | The Binding of Isaac: Rebirth
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| 330. | Is It Possible To Win Isaac Run Without ANY Kills? | 99 | | The Binding of Isaac: Rebirth
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| 331. | This New Character Has Cursed Items! Bael Gameplay! | 111 | | The Binding of Isaac: Rebirth
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| 332. | This New Token Bag Is Absolutely Broken! 100% Red Room Chance! | 94 | | The Binding of Isaac: Rebirth
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| 333. | This New Pepper Item Is Absolutely BROKEN! | 116 | | The Binding of Isaac: Rebirth
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| 334. | I Finally Got The Best Item For Tainted Samael! | 103 | | The Binding of Isaac: Rebirth
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| 335. | I Got The Most Powerful Bag Synergy Ever! | 95 | | The Binding of Isaac: Rebirth
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| 336. | I Played The Most Expensive Isaac Challenge Ever! Epiphany Challenge #6 | 114 | | The Binding of Isaac: Rebirth
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| 337. | This New Character Is Extremely Broken! | 112 | | The Binding of Isaac: Rebirth
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| 338. | They Added A New Upgradable Meat Boy! It's Extremely Cute! | 111 | | The Binding of Isaac: Rebirth
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| 339. | I Got The Fastest Brimstone Ever! Luckiest Tarnished Eden Run! | 97 | | The Binding of Isaac: Rebirth
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| 340. | The Luckiest Character Ever Made! Tainted Zach Gameplay! | 112 | | The Binding of Isaac: Rebirth
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| 341. | Binding Of Isaac, But I Can Only Jump To WIn | 118 | | The Binding of Isaac: Rebirth
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| 342. | This New Planetarium Transformation In Isaac Is AMAZING! | 118 | | The Binding of Isaac: Rebirth
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| 343. | This New Character Dies When The Time Runs Out! Chronos Gameplay! | 103 | | The Binding of Isaac: Rebirth
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| 344. | I Finally Unlocked Tarnished Cain! (The New Way) | 101 | | The Binding of Isaac: Rebirth
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| 345. | I Got Golden Diplopia And It's Insane! | 101 | | The Binding of Isaac: Rebirth
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| 346. | This New Tarnished Character Is Too Overpowered! Tarnished Chamuel Gameplay! | 103 | | The Binding of Isaac: Rebirth
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| 347. | Angel Items Everyone Wants To See! Ultra Lucky Tainted Lost! | 103 | | The Binding of Isaac: Rebirth
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| 348. | Playable Damocles Is Literally Broken! | 116 | | The Binding of Isaac: Rebirth
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| 349. | Champion Tainted Jacob Is Extremely Hard... | 108 | | The Binding of Isaac: Rebirth
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| 350. | I Tried New Insane Mode In Isaac And This Happened: | 135 | | The Binding of Isaac: Rebirth
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| 351. | This New Tainted Character Can Evolve! | 117 | | The Binding of Isaac: Rebirth
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| 352. | These Tainted Planetarium Items Are Completely CURSED! | 111 | | The Binding of Isaac: Rebirth
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| 353. | The Easiest Tainted Maggy Run In The Game? Fiend Folio Challenge #2 | 108 | | The Binding of Isaac: Rebirth
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| 354. | They Made A Harder Tainted Forgotten Version? Abihu Gameplay! | 135 | | The Binding of Isaac: Rebirth
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| 355. | You Won't Believe I Got Rock Bottom Like This! | 110 | | The Binding of Isaac: Rebirth
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| 356. | Tainted Lost Gamebreak.exe | 111 | | The Binding of Isaac: Rebirth
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| 357. | Unlocking The Most Broken Character Ever! (GONE WRONG) | 135 | | The Binding of Isaac: Rebirth
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| 358. | This New Character Has Infinite Items! Unbidden Gameplay! | 126 | | The Binding of Isaac: Rebirth
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| 359. | I Got Spindown Dice With INFINITE Charges! | 127 | | The Binding of Isaac: Rebirth
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| 360. | What Happens If Forgotten Gets Too Many Damage Multipliers? | 114 | | The Binding of Isaac: Rebirth
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| 361. | Blue flamethrower! Tainted Lost to Mother #3 | 115 | | The Binding of Isaac: Rebirth
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| 362. | I Got Red Tarnished Judas?! Luckiest First Floor Ever! | 116 | | The Binding of Isaac: Rebirth
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| 363. | This New Character Is LITERALLY Immortal! | 127 | | The Binding of Isaac: Rebirth
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| 364. | You Need Only One Item To Break The Game! Tarnished Keeper Glitched Crown Start! | 117 | | The Binding of Isaac: Rebirth
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| 365. | Tarnished Lost Is Extremely Hard... | 132 | | The Binding of Isaac: Rebirth
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| 366. | They Turned Mongo Baby Into A New Character?! | 134 | | The Binding of Isaac: Rebirth
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| 367. | This New Tarnished Eden Birthright Is Insanely Good! | 121 | | The Binding of Isaac: Rebirth
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| 368. | First Second Autowin! Luckiest Tainted Jacob Run! | 122 | | The Binding of Isaac: Rebirth
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| 369. | How Did I Break The Game Using Only One Chest!? Luckiest Tainted Azazel Ever! | 123 | | The Binding of Isaac: Rebirth
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| 370. | I Finally Got The Rarest Game Break Ever! Infinite Dupe Synergy! | 124 | | The Binding of Isaac: Rebirth
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| 371. | This Is The Craziest Tarnished Character Ever! Tarnished Samson Unlock! | 124 | | The Binding of Isaac: Rebirth
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| 372. | I Finally Got The Most Random Character In The Game! Tarnished Eden Unlock! | 125 | | The Binding of Isaac: Rebirth
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| 373. | The Most Expensive Deal I've Ever Done! 50+ Hearts Damocles! | 125 | | The Binding of Isaac: Rebirth
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| 374. | The Luckiest Challenge I've Ever Had! Fiend Folio Challenge #10 | 125 | | The Binding of Isaac: Rebirth
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| 375. | The Bloodiest Character In The Game! Tarnished Maggy Gameplay! | 125 | | The Binding of Isaac: Rebirth
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| 376. | This New Character Is Too Explosive... Nadab Gameplay! | 139 | | The Binding of Isaac: Rebirth
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| 377. | Tarnished Keeper Has Finally Found Them! | 129 | | The Binding of Isaac: Rebirth
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| 378. | This New Dice Literally Broke My PC! Tainted Keeper's Loaded D6 Experience! | 131 | | The Binding of Isaac: Rebirth
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| 379. | I Got The Best Item For Tarnished Maggy! | 132 | | The Binding of Isaac: Rebirth
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| 380. | This New Character Is Insane! Tarnished Samson Release! | 132 | | The Binding of Isaac: Rebirth
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| 381. | I Gulped EVERY Trinket In Isaac And This Happened: | 135 | | The Binding of Isaac: Rebirth
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| 382. | What Happens If Tainted Samael Gets Ipecac... | 138 | | The Binding of Isaac: Rebirth
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| 383. | These New Bag Synergies Are Amazing! Tarnished Cain Gameplay! | 133 | | The Binding of Isaac: Rebirth
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| 384. | These Hands Won't Let Me Go! Fiend Folio Bonus Challenge! | 135 | | The Binding of Isaac: Rebirth
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| 385. | This Guy Is Too Overpowered! Trying Tarnished Isaac For The First Time! | 136 | | The Binding of Isaac: Rebirth
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| 386. | Another Tarnished Character Is Here! How To Unlock Tarnished Maggy? | 137 | Guide | The Binding of Isaac: Rebirth
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| 387. | The Most Broken Character In The Game! Trying Tarnished Eden For The First Time! | 138 | | The Binding of Isaac: Rebirth
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| 388. | I Finally Found This Secret Revelations Room! | 155 | | The Binding of Isaac: Rebirth
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| 389. | They Made A Playable Host And It's INSANE! | 141 | | The Binding of Isaac: Rebirth
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| 390. | Trying Tarnished Judas For The First Time! Amazing Tainted Knife Synergy! | 141 | | The Binding of Isaac: Rebirth
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| 391. | Isaac Run, But Every Enemy Has Homing! | 144 | | The Binding of Isaac: Rebirth
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| 392. | Double Death Certificate On The First Floor! The Luckiest Azazel Run In The World! | 145 | | The Binding of Isaac: Rebirth
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| 393. | This New Character Creates A Completely New Reality! | 150 | | The Binding of Isaac: Rebirth
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| 394. | They Made A Challenge For Tarnished Lost?! Epiphany Challenge #9 | 179 | | The Binding of Isaac: Rebirth
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| 395. | What Can 3000+ Hours Isaac Player Do On The First Floor? | 148 | | The Binding of Isaac: Rebirth
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| 396. | Tainted Lost Tmtrainer Experience... Custom Challenge Gone Wrong | 150 | | The Binding of Isaac: Rebirth
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| 397. | This New Keeper's Penny Upgrades Shops To The Next Level! | 256 | | The Binding of Isaac: Rebirth
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| 398. | I Found The Most Broken Lost EVER! | 172 | | The Binding of Isaac: Rebirth
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| 399. | The Greediest Run You Have Ever Seen! Tarnished Keeper VS Greedier! | 153 | | The Binding of Isaac: Rebirth
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| 400. | Tarnished Judas Unlock! The Best Golden Brimstone Synergy Ever! | 154 | | The Binding of Isaac: Rebirth
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