| 401. | This Is Why I Rig Every Run In Isaac! | 67 | | The Binding of Isaac: Rebirth
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| 402. | These New Angel Bosses Are Insanely HARD! | 87 | | The Binding of Isaac: Rebirth
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| 403. | Isaac Run, But Every Room I Get A New Character! | 79 | | The Binding of Isaac: Rebirth
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| 404. | I Found The Best Familiar In The Game! It's CRAZY! | 89 | | The Binding of Isaac: Rebirth
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| 405. | This New Item Changes Your Tears With Giant Brimstone! | 111 | | The Binding of Isaac: Rebirth
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| 406. | This New Quality 4 Item Has INSANE Synergies! | 452 | | The Binding of Isaac: Rebirth
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| 407. | Isaac Will Never Be The Same Again... | 100 | | The Binding of Isaac: Rebirth
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| 408. | This New Isaac Transformation Is Literally CURSED! | 74 | | The Binding of Isaac: Rebirth
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| 409. | This New Quality 4 Gives You Every Item Possible! | 127 | | The Binding of Isaac: Rebirth
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| 410. | Isaac, But Every Enemy Is Also Isaac | 172 | | The Binding of Isaac: Rebirth
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| 411. | New Final Boss And New Ending! Unlocking Secret Character In Isaac! | 262 | | The Binding of Isaac: Rebirth
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| 412. | I Played The Most Unpleasant Isaac Challenge Ever... | 73 | | The Binding of Isaac: Rebirth
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| 413. | This New Guppy Transformation Changes Everything! | 89 | | The Binding of Isaac: Rebirth
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| 414. | This New Rock Bottom Almost Destroyed My PC! | 308 | | The Binding of Isaac: Rebirth
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| 415. | They Turned Slot Machine Into A Character?! It's INSANE! | 154 | | The Binding of Isaac: Rebirth
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| 416. | This New Satan's Contract Gave Me Unlimited Power! | 123 | | The Binding of Isaac: Rebirth
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| 417. | Isaac Run, But Every Item Is A Golden Horse Pill... | 217 | | The Binding of Isaac: Rebirth
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| 418. | This New Character Can Create Familiars! Tainted Siren Gameplay! | 101 | | The Binding of Isaac: Rebirth
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| 419. | I Finally Got ALL Achievements In Isaac And It's INSANE! | 87 | | The Binding of Isaac: Rebirth
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| 420. | I Created My Own Immortal Mini Isaac Army! | 94 | | The Binding of Isaac: Rebirth
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| 421. | Playable Blood Donation Machine Is Too Horrifying! | 553 | | The Binding of Isaac: Rebirth
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| 422. | These New Isaac Unlocks Are INSANE! | 158 | | The Binding of Isaac: Rebirth
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| 423. | I Found The Most Broken Room In Isaac History! | 78 | | The Binding of Isaac: Rebirth
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| 424. | Isaac Online Is Finally Out! Getting New Achievements & More! | 92 | | The Binding of Isaac: Rebirth
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| 425. | This New Cyborg Transformation Is Literally BROKEN! | 126 | | The Binding of Isaac: Rebirth
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| 426. | This New Silver Crown Gave Me Infinite Stats! | 96 | | The Binding of Isaac: Rebirth
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| 427. | They Added A New Spider Character! It's Extremely Cute! | 120 | | The Binding of Isaac: Rebirth
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| 428. | I Broke World Record And Became The Richest Isaac Player! | 113 | | The Binding of Isaac: Rebirth
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| 429. | I Finally Got The Craziest Tainted Samael Synergy! | 85 | | The Binding of Isaac: Rebirth
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| 430. | All Isaac Transformations In One Run! | 115 | | The Binding of Isaac: Rebirth
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| 431. | This New Keeper Challenge Is Extremely Hard! | 161 | | The Binding of Isaac: Rebirth
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| 432. | I Opened Every Single Room In Isaac With This New Item! | 274 | | The Binding of Isaac: Rebirth
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| 433. | I Finally Got The Biggest Brimstone In Isaac History! | 120 | | The Binding of Isaac: Rebirth
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| 434. | This New Playable Dead Isaac Is Insane! | 198 | | The Binding of Isaac: Rebirth
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| 435. | Isaac, But He Has Finally Grown Up! | 122 | | The Binding of Isaac: Rebirth
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| 436. | I Found A New Ultra Rare Isaac Miniboss! | 119 | | The Binding of Isaac: Rebirth
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| 437. | Isaac, But Every Time I Die I Get More Stats! | 62 | | The Binding of Isaac: Rebirth
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| 438. | I Got The Best Familiar Upgrade EVER! | 142 | | The Binding of Isaac: Rebirth
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| 439. | Can I Survive With Isaac's Heart As Tainted Lost? | 80 | | The Binding of Isaac: Rebirth
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| 440. | This New Character Can Spawn Army Of Zombies! | 164 | | The Binding of Isaac: Rebirth
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| 441. | This New Character Can Create Isaac Army! | 118 | | The Binding of Isaac: Rebirth
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