| 301. | How to make Glacial Acetic Acid | 298,983 | |
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| 302. | Dissolving Cotton and Paper in Water (using Schweizer's Reagent) | 296,116 | |
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| 303. | Making Calcium Acetate (from eggshells) | 296,015 | |
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| 304. | Making oxalic acid from cane sugar | 274,379 | |
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| 305. | Aspirin to Acetaminophen - Part 1 of 6: Extracting Aspirin from Pills | 272,236 | |
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| 306. | How to make Calcium Hydroxide (Ca(OH)2) | 266,096 | |
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| 307. | Making Wintergreen (a minty odor and flavoring) | 264,621 | |
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| 308. | How to make Sodium Carbonate (from Sodium Bicarbonate) | 262,957 | |
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| 309. | Reacting Bromine and Aluminum | 255,037 | |
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| 310. | Technique Series: Recrystallization (urea as an example) | 250,517 | |
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| 311. | Making Benzaldehyde From Cinnamon Oil | 244,129 | |
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| 312. | Making Alcohol Jelly (from Calcium Acetate) | 235,287 | |
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| 313. | Making Chromyl Chloride | 235,016 | |
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| 314. | How to make Aniline | 230,167 | |
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| 315. | How to Freebase (Phenylhydrazine HCl as an example) | 227,432 | |
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| 316. | All about Sodium | Element Series | 226,615 | |
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| 317. | How to make Nitrobenzene | 224,924 | |
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| 318. | How to make Banana, Mushroom, Orange, and Pear Flavoring (Acetate Esters) | 222,358 | |
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| 319. | Making Vanillin Oxime (Capsaicin precursor) | 221,793 | |
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| 320. | Making Lithium Peroxide | 213,325 | |
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| 321. | Storing mercury without water | 211,156 | |
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| 322. | Making Benzyl Chloride | 208,808 | |
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| 323. | Melting Zinc Battery Casings into an Ingot | 200,899 | |
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| 324. | Making Stinky Pyridine from Vitamin B3 | 197,654 | |
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| 325. | How to make a Phenolphthalein Indicator Solution (0.05%wt) | 196,764 | |
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| 326. | How to make a Stannous Chloride Solution (Tin (II) Chloride) | 192,684 | |
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| 327. | How to make cadaverine (the smell of death) | 184,539 | |
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| 328. | Making a Nylon Precursor using Green Chemistry | 173,823 | |
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| 329. | The Burning of Sulfur (Demonstration) | 172,917 | |
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| 330. | Making elemental bromine | 166,203 | |
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| 331. | Making a Bromoalkane (1-bromopentane) | 160,128 | |
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| 332. | The Briggs-Rausher Oscillating Reaction (Tutorial and Explanation) | 158,588 | |
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| 333. | Making Magnesium Silicide and Explosive Silane Gas | 153,557 | |
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| 334. | Aspirin to Acetaminophen - Part 2 of 6: Conversion of ASA to Salicylic Acid | 150,044 | |
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| 335. | Making Phenol | 150,042 | |
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| 336. | Aspirin to Acetaminophen - Part 4 of 6: Mono-nitration of Phenol | 148,577 | |
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| 337. | Fuming Nitric Acid vs. Lab Gloves | 148,357 | |
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| 338. | Making calcium acetate from Tums | 143,568 | |
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| 339. | How to make Manganese Heptoxide | 143,031 | |
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| 340. | Cleaning Dirty Phenol | 141,038 | |
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| 341. | Making Benzaldehyde from Bitter Almond Oil | 140,942 | |
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| 342. | Making a fluorescent dye - Eosin Y | 140,710 | |
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| 343. | Dissolving pork in hot piranha solution | 139,809 | |
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| 344. | How to make Grape Flavoring (methyl anthranilate) | 139,619 | |
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| 345. | Aspirin to Acetaminophen - Part 6 of 6: Acetaminophen from p-aminophenol | 132,151 | |
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| 346. | Aspirin to Acetaminophen - Part 3 of 6: Phenol from Salicylic Acid | 126,809 | |
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| 347. | Demonstration of Instant Snow (Sodium Polyacrylate) | 119,603 | |
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| 348. | How to make Putrescine | 119,441 | |
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| 349. | Making Methyl Iodide | 117,140 | |
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| 350. | How to make Butyric Acid (Smell of Vomit) - Oxidation Method | 116,487 | |
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| 351. | How to make Butyric Acid (Grignard Reaction) | 116,311 | |
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| 352. | Making Anhydrous Oxalic Acid (using a Dean-Stark Apparatus) | 116,170 | |
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| 353. | How to Separate Dichloromethane (DCM, Methylene Chloride) from Paint Remover | 115,459 | |
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| 354. | Glycerol and Potassium Permanganate | 114,725 | |
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| 355. | Making a Hydrogen Sulfide Generator | 114,622 | |
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| 356. | How to make an Oxygen Generator (MnO2/H2O2 Method) | 113,325 | |
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| 357. | Making Ammonium Formate | 108,835 | |
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| 358. | How to isolate Vanillin from Artificial Vanilla Extract | 104,557 | |
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| 359. | How to make Phthalic acid and Phthalic Anhydride | 104,278 | |
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| 360. | How to make Propanal (propionaldehyde) | 104,156 | |
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| 361. | Aspirin to Acetaminophen - Part 5 of 6: Reducing p-nitrophenol to p-aminophenol | 102,641 | |
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| 362. | How to extract Vanillin from Vanilla Sugar | 95,472 | |
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| 363. | Making Benzoic Acid (from sodium benzoate) | 89,018 | |
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| 364. | How to make the Cinnamaldehyde Clock | 87,797 | |
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| 365. | Brominating an Alcohol using Phosphorus Tribromide (1-pentanol) | 87,144 | |
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| 366. | How to extract Acetylsalicylic Acid from Aspirin Tablets | 81,858 | |
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| 367. | Preparing a Drying Agent (Magnesium sulfate) | 81,833 | |
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| 368. | How to Convert Aspirin to Salicylic Acid (Base Hydrolysis Method) | 81,468 | |
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| 369. | Making Ammonium Metavanadate | 72,488 | |
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| 370. | Let me Cook You a Meal (for reaching 50K Subs). | 68,904 | |
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| 371. | Extracting vitamin B3 (niacin) from pills | 61,199 | |
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| 372. | Spontaneous Combustion: Silane Gas | 61,026 | |
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| 373. | How to prepare the Iodine Clock Reaction | 57,020 | |
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| 374. | Playing with an InfraRed Camera (reuploaded) | 53,379 | |
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| 375. | Making Phenylhydrazine (Skatole precursor) | 53,367 | |
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| 376. | Making 3-nitrophthalic Acid (Luminol Precursor) | 50,742 | |
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| 377. | How to make Hydrobromic Acid | 50,637 | |
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| 378. | How to make Phthalimide | 48,151 | |
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| 379. | How to make an Acid and Base Bath | 45,587 | |
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| 380. | Synthesis of a Bromoalkane (n-Bromopropane) | 42,453 | |
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| 381. | Hot Piranha Eating a Fortune Cookie | 42,079 | |
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| 382. | Making Instant Coke (Iodine Clock Demonstration - Not Real Coke) | 39,867 | |
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| 383. | The Briggs-Rausher Oscillating Reaction (Demonstration) | 16,472 | |
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| 384. | Make your Requests, Comments and Suggestions Here!! | 9,642 | |
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