Top 100 The Binding of Isaac Videos With The Most Comments by Joshua KanaiTop 100 » 200 » 300 » 400 » 500Video TitleCommentsCategoryGame1.WHAT KINDA ENDING IS THIS?? | #Shorts #TBoI #TheBindingofIsaac14The Binding of Isaac 2.BOMBS are the BEST WEAPON against Mom's Heart | TBoI: Judas | FINAL6The Binding of Isaac 3.Getting a PHD for GOOD PILLS ONLY | TBoI: Judas | PT104The Binding of Isaac 4.IS CHOCCY MILK BETTER THAN I THOUGHT? | TBoI: Cain | PT024The Binding of Isaac 5.Can we Come Back From this MASSIVE Mistake? | TBoI: Judas | PT122The Binding of Isaac 6.BECOMING ??? (Blue Baby) | TBoI: Judas (but actually Cain) | PT092The Binding of Isaac 7.THE IRREMOVABLE TICK | TBoI: Judas | PT072The Binding of Isaac 8.MY MOM KILLED ME | The Binding of Isaac | Attempt 022The Binding of Isaac 9.THIS CHARACTER IS SO HARD | TBoI: Judas | PT012The Binding of Isaac 10.WE ARE BACK WITH IT | TBoI: Magdalene | Attempt 012The Binding of Isaac 11.SECRET PILL ROOM | TBoI: Judas | PT020The Binding of Isaac 12.LUCKY FOOT IS SO OVERPOWERED | TBoI: Eve | PT030The Binding of Isaac 13.THE ABSOLUTE WORST RUNS | TBoI: Judas | PT030The Binding of Isaac 14.This Run Was Beat Until... | TBoI: Samson | PT010The Binding of Isaac 15.The Best Item Set We've Ever Gotten | The Binding of Isaac | Attempt 050The Binding of Isaac 16.Lucking Into ERROR ROOMS | TBoI: Samson | FINAL0The Binding of Isaac 17.Betting it ALL on NINE LIVES | TBoI: Magdalene | FINAL/Attempt 020The Binding of Isaac 18.BLESSED BY THE HOLY GRAIL | TBoI: Judas | PT050The Binding of Isaac 19.NEVER TRUST THE SACRIFICIAL ROOMS | The Binding of Isaac | Attempt 030The Binding of Isaac 20.Is DEAD CAT Worth It? | TBoI: Eve | PT020The Binding of Isaac 21.CAIN WE DO THIS? NO WE CAIN'T | TBoI: Cain | PT1 (HAVE A HAPPY NEW YEAR!!!)0The Binding of Isaac 22.MUTANT SPIDER for INSANE QUAD SHOTS | TBoI: Eve | PT010The Binding of Isaac 23.I GOT CANCER | The Binding of Isaac | Attempt 010The Binding of Isaac 24.TO BE GREEDY, OR SAFE? | TBoI: Judas | PT040The Binding of Isaac 25.HOW MANY CHUBS ARE THERE?! | TBoI: Cain | FINAL0The Binding of Isaac 26.OUR CLOSEST ATTEMPT YET | TBoI: Judas | PT060The Binding of Isaac 27.WE DID IT | The Binding of Isaac | Final (Attempt 07)0The Binding of Isaac 28.The Powers of The ANKH | TBoI: Eve | PT040The Binding of Isaac 29.THIS BOSS TOOK FOREVER | TBoI: Judas | PT080The Binding of Isaac 30.IPECAC For Overpowered EXPLOSIVE SHOTS | TBoI: Judas | PT110The Binding of Isaac Top 100 » 200 » 300 » 400 » 500