| 401. | Isaac, but I don't like getting good items | 5,748 | | The Binding of Isaac: Rebirth
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| 402. | This New Final Boss And Ending Were Simply Amazing | 6,565 | | The Binding of Isaac: Rebirth
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| 403. | EVERY ITEM, 1 ROOM | 5,953 | | The Binding of Isaac: Rebirth
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| 404. | The Binding of Isaac But I Can't See | 0 | | The Binding of Isaac: Rebirth
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| 405. | Most Satisfying Devil Deal | 0 | | The Binding of Isaac: Rebirth
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| 406. | This is my RISKIEST run yet | 0 | | The Binding of Isaac: Rebirth
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| 407. | How I Shot 1000+ Brimstones Per Second | 0 | | The Binding of Isaac: Rebirth
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| 408. | Tainted Lost is Pure ANXIETY | 0 | | The Binding of Isaac: Rebirth
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| 409. | This BROKE my PC | 0 | | The Binding of Isaac: Rebirth
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| 410. | This Shop has the BEST Items: | 0 | | The Binding of Isaac: Rebirth
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| 411. | Unluckiest Youtuber Be Like: | 0 | | The Binding of Isaac: Rebirth
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| 412. | How I Got ROCK BOTTOM in 1.79 Seconds | 0 | | The Binding of Isaac: Rebirth
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| 413. | Luckiest First Floor | 0 | | The Binding of Isaac: Rebirth
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| 414. | Unlocking Holy Card | 0 | | The Binding of Isaac: Rebirth
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| 415. | Every Item is VANISHING TWIN with NO ITEMS Isaac: Repentance | 0 | | The Binding of Isaac: Rebirth
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| 416. | I Bought CHEATS in Repentance | 0 | | The Binding of Isaac: Rebirth
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| 417. | I got TOO many items | 0 | | The Binding of Isaac: Rebirth
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| 418. | GODLY Rerolls | 0 | | The Binding of Isaac: Rebirth
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| 419. | Average Bethany Run: | 0 | | The Binding of Isaac: Rebirth
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| 420. | So I Ranked Isaac Items... | 0 | | The Binding of Isaac: Rebirth
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| 421. | I Got INFINITE Tears. It was a mistake. | 0 | | The Binding of Isaac: Rebirth
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| 422. | Unlocking Godhead | 0 | | The Binding of Isaac: Rebirth
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| 423. | Most Satisfying Luck | 0 | | The Binding of Isaac: Rebirth
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| 424. | The FASTEST Break I've Ever Had | 0 | | The Binding of Isaac: Rebirth
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| 425. | How I beat Hush with ONE TEAR In Repentance | 0 | | The Binding of Isaac: Rebirth
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| 426. | When the First Floor Gives You THIS | 0 | | The Binding of Isaac: Rebirth
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| 427. | Unlocking 1,000,000% | 0 | | The Binding of Isaac: Rebirth
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| 428. | This Upgraded Magic Skin Is INCREDIBLE | 5,052 | | The Binding of Isaac: Rebirth
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| 429. | This Secret Character Has CRAZY Synergies | 5,164 | | The Binding of Isaac: Rebirth
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| 430. | Greediest Beggar | 948 | |
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| 431. | How I Beat Hush in Under 5 Seconds: | 4,676 | | The Binding of Isaac: Rebirth
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| 432. | Infinite Black Hole Synergy!? | 1,068 | | The Binding of Isaac: Rebirth
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| 433. | Can I lose? | 1,082 | |
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| 434. | Big Mistake | 1,091 | |
|
| 435. | Run Saving SYNERGY | 1,099 | |
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| 436. | I Got The Most BEAUTIFUL Start In Isaac History... | 4,872 | | The Binding of Isaac: Rebirth
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| 437. | Mommy's Crushing Me | 1,155 | |
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| 438. | The NEW Knife Item Is So Satisfying | 4,836 | | The Binding of Isaac: Rebirth
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| 439. | I Got The Most SATISFYING Start Ever: | 6,345 | | The Binding of Isaac: Rebirth
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| 440. | Splitting Laser Lung | 1,225 | | The Binding of Isaac: Rebirth
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| 441. | Cursed Reflecting Ipecac | 1,230 | | The Binding of Isaac: Rebirth
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| 442. | They Added LINK To Isaac!! | 3,599 | | The Binding of Isaac: Rebirth
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| 443. | This New Item Gives FREE Quality 4's: | 6,306 | | The Binding of Isaac: Rebirth
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| 444. | LARGE Future Babies | 1,257 | | The Binding of Isaac: Rebirth
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| 445. | SUPER Damage Multiplier | 1,257 | | The Binding of Isaac: Rebirth
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| 446. | ALWAYS Take Chaos | 1,265 | |
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| 447. | Infinite Tears Synergy? | 1,274 | |
|
| 448. | Unlocking The D6 | 1,306 | | The Binding of Isaac: Rebirth
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| 449. | I Played The WEIRDEST Isaac Character: | 5,549 | | The Binding of Isaac: Rebirth
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| 450. | Lilith + Greedier Moment | 1,324 | | The Binding of Isaac: Rebirth
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| 451. | First Floor Shop Be Like | 1,350 | | The Binding of Isaac: Rebirth
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| 452. | This New Mod Is TERRIFYING | 5,960 | | The Binding of Isaac: Rebirth
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| 453. | Unlocking Tainted Cain | 1,416 | | The Binding of Isaac: Rebirth
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| 454. | LUCKIEST Reroll | 1,424 | | The Binding of Isaac: Rebirth
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| 455. | HUGE Mistake | 1,438 | | The Binding of Isaac: Rebirth
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| 456. | Skipping the entire game | 1,450 | |
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| 457. | Most Satisfying Character EVER | 5,447 | | The Binding of Isaac: Rebirth
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| 458. | Polyphemus Start | 1,481 | | The Binding of Isaac: Rebirth
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| 459. | Unlocking Revelation | 1,491 | | The Binding of Isaac: Rebirth
|
| 460. | Luckiest Secret Room | 1,510 | |
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| 461. | This New Item Gives INFINITE Familiars. It's Insane. | 5,020 | | The Binding of Isaac: Rebirth
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| 462. | Completing ALL Tainted Lost Marks Before Anyone Else | 1,543 | | The Binding of Isaac: Rebirth
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| 463. | Controllable Laser Frenzy | 1,543 | | The Binding of Isaac: Rebirth
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| 464. | This New Quality 4 Item Is INSANE | 6,209 | | The Binding of Isaac: Rebirth
|
| 465. | This New Forgotten Changes EVERYTHING!! | 5,434 | | The Binding of Isaac: Rebirth
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| 466. | The Angel Room Incident | 1,611 | | The Binding of Isaac: Rebirth
|
| 467. | Unlocking Tainted Isaac | 1,633 | | The Binding of Isaac: Rebirth
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| 468. | Pummeling Final Bosses with Red key + R Key | 1,639 | | The Binding of Isaac: Rebirth
|
| 469. | Unlocking Holy Mantle | 1,666 | | The Binding of Isaac: Rebirth
|
| 470. | The ULTIMATE Brimstone Combo | 1,671 | | Brimstone
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| 471. | Golden God Already? | 1,680 | |
|
| 472. | This Synergy is INCREDIBLE.. | 1,729 | |
|
| 473. | The Quest For The Second Dead God | 1,741 | |
|
| 474. | Double the Tears, Double the Damage | 1,743 | | The Binding of Isaac: Rebirth
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| 475. | I SPEEDRUN The FASTEST Brimstone World Record | 1,800 | | The Binding of Isaac: Rebirth
|
| 476. | Unlocking The Forgotten | 1,809 | |
|
| 477. | Isaac In The B̴̰̥̞̌A̷̡͍̦̥̖̒̔C̸̖͗̓̄̌̕K̷̝̽̾R̴̟͊͑̾̏̐̾O̵̘̹͚͊̓̆̎̾͑O̵̧̨̠̲̤̱̔̔͋͝͝ͅM̶̧̼̮͇͙̃S̶͔̹̺͖͓͈̀̅̈́̿͑̚͜͝ | 1,831 | | The Binding of Isaac: Rebirth
|
| 478. | Unlocking Tainted Forgotten | 1,859 | | The Binding of Isaac: Rebirth
|
| 479. | The Character That's INSANELY Satisfying... | 5,051 | | The Binding of Isaac: Rebirth
|
| 480. | They Turned Isaac Into A Horror Game. It's TERRIFYING. | 9,890 | | The Binding of Isaac: Rebirth
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| 481. | Greediest BRIMSTONE Free Win.. | 1,926 | | The Binding of Isaac: Rebirth
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| 482. | This Isaac Challenge Is FREAKY | 4,319 | | The Binding of Isaac: Rebirth
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| 483. | Least Broken Red Key Run | 1,978 | | The Binding of Isaac: Rebirth
|
| 484. | Finally, GUNS in Isaac | 4,817 | | The Binding of Isaac: Rebirth
|
| 485. | Unlocking 1001% | 2,007 | | The Binding of Isaac: Rebirth
|
| 486. | How I Got the BEST Items for FREE | 2,009 | | The Binding of Isaac: Rebirth
|
| 487. | Least Rigged Youtuber Run: | 2,074 | | The Binding of Isaac: Rebirth
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| 488. | LASER Fever Tainted Lost | 2,081 | | The Binding of Isaac: Rebirth
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| 489. | How I Got 10,000+ Damage Per Second | 2,098 | | The Binding of Isaac: Rebirth
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| 490. | Sacred Ultra Fetus Bombs | 2,132 | | The Binding of Isaac: Rebirth
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| 491. | How ONE Reroll CRASHED My Game | 2,138 | | The Binding of Isaac: Rebirth
|
| 492. | Unlocking Rock Bottom | 2,142 | | The Binding of Isaac: Rebirth
|
| 493. | TOO Many Lasers | 2,156 | |
|
| 494. | Sacred Mega Lasers | 2,159 | |
|
| 495. | Unlocking Confessionals | 2,161 | | The Binding of Isaac: Rebirth
|
| 496. | The LUCKIEST Rig Ever | 4,826 | | The Binding of Isaac: Rebirth
|
| 497. | Is THIS My Worst Synergy Ever? | 2,232 | | The Binding of Isaac: Rebirth
|
| 498. | This ROCK BOTTOM Character Is Depressing | 4,637 | | The Binding of Isaac: Rebirth
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| 499. | This Synergy WILL Satisfy You | 2,246 | | The Binding of Isaac: Rebirth
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| 500. | The EASIEST Free Win | 2,269 | | The Binding of Isaac: Rebirth
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