| 201. | Trisaigon Is Bugged In The Beast Fight! (The Binding of Isaac: Repentance) | 3 | | The Binding of Isaac: Rebirth
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| 202. | Delete This Challenge, Complete (The Binding of Isaac: Repentance) | 3 | | The Binding of Isaac: Rebirth
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| 203. | DOOMED (The Binding of Isaac: Afterbirth+) [128] | 3 | | The Binding of Isaac: Rebirth
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| 204. | I FINALLY BEAT GREEDIER AS CAIN! (The Binding of Isaac: Afterbirth+) | 3 | Walkthrough | The Binding of Isaac: Rebirth
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| 205. | SUICIDE KING (The Binding of Isaac: Afterbirth+) [132] | 3 | | The Binding of Isaac: Rebirth
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| 206. | RAGEQUIT (The Binding of Isaac: Afterbirth+) (#128) | 3 | | The Binding of Isaac: Rebirth
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| 207. | Delete This Challenge Attempt X (The Binding of Isaac: Repentance) | 3 | | The Binding of Isaac: Rebirth
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| 208. | IMPORTANT, PLEASE WATCH! (The Binding of Isaac: Repentance) [Delete This Challenge] | 3 | | The Binding of Isaac: Rebirth
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| 209. | POGTONIUM (The Binding of Isaac: Afterbirth+) [157] | 3 | | The Binding of Isaac: Rebirth
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| 210. | Pay to Play Attempt 1 (The binding of Isaac: Repentance) | 3 | | The Binding of Isaac: Rebirth
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| 211. | NDP Streams The Binding of Isaac: Afterbirth+ [Birthday] | 3 | Let's Play | The Binding of Isaac: Rebirth
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| 212. | The Haunt (Boss Battle) [The Binding of Isaac: Afterbirth+] | 3 | Let's Play | The Binding of Isaac: Rebirth
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| 213. | THE MOST EPIC CHEST BREAK YOU HAVE EVER SEEN! (The Binding of Isaac: Afterbirth+) | 3 | | The Binding of Isaac: Rebirth
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| 214. | BUT I WAS ALMOST THERE! (The Binding of Isaac: Afterbirth+) | 3 | | The Binding of Isaac: Rebirth
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| 215. | SHARP STRAW! (The Binding of Isaac: Repentance) [Judas] | 3 | | The Binding of Isaac: Rebirth
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| 216. | Isaac Is Mean (The Binding of Isaac: Repentance) [Apollyon] | 3 | | The Binding of Isaac: Rebirth
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| 217. | HARDSHIP (The Binding of Isaac: Afterbirth+) [147] | 3 | | The Binding of Isaac: Rebirth
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| 218. | I Just Can't Win (The Binding of Isaac: Repentance) [Blue Baby] | 3 | | The Binding of Isaac: Rebirth
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| 219. | BETHANY.GET (The Binding of Isaac: Repentance) | 3 | | The Binding of Isaac: Rebirth
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| 220. | The Binding of Isaac: Afterbirth+ (R088-89) [MINIMAX] | 3 | | The Binding of Isaac: Rebirth
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| 221. | The Binding of Isaac: Afterbirth+ (R083-84) [DESERVED] | 3 | | The Binding of Isaac: Rebirth
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| 222. | Greatest Video Game Music of All Time: River of Despair (Downpour Theme) [The Binding of Isaac) | 3 | | The Binding of Isaac: Rebirth
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| 223. | The Game Finds A Way (The Binding of Isaac: Repentance) [The Lost] | 3 | | The Binding of Isaac: Rebirth
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| 224. | HOPELESS!!! 😭 (The Binding of Isaac: Afterbirth+) [111] | 3 | | The Binding of Isaac: Rebirth
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| 225. | WHAT THE HECK? (The Binding of Isaac: Repentance) [The Lost] | 3 | | The Binding of Isaac: Rebirth
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| 226. | WEIRD AUDIO PROBLEMS? (The Binding of Isaac: Repentance) [The Lost] | 3 | | The Binding of Isaac: Rebirth
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| 227. | Hush, No Damage (Boss Battle) [The Binding of Isaac: Afterbirth+] | 2 | | The Binding of Isaac: Rebirth
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| 228. | SOLAR SYSTEM (The Binding of Isaac: Afterbirth+) [131] | 2 | | The Binding of Isaac: Rebirth
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| 229. | A GRAVE MISTAKE (The Binding of Isaac: Repentance) [Tainted Lost] | 2 | | The Binding of Isaac: Rebirth
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| 230. | SLOW ROLL (The Binding of Isaac: Afterbirth+) [160] | 2 | | The Binding of Isaac: Rebirth
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| 231. | Greedier is Impossible Now (The Binding of Isaac: Repentance) [Tainted Samson] | 2 | | The Binding of Isaac: Rebirth
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| 232. | DOWNHEARTED (The Binding of Isaac: Afterbirth+) [141] | 2 | Walkthrough | The Binding of Isaac: Rebirth
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| 233. | ALRIGHT ISAAC. FINE. (The Binding of Isaac: Afterbirth+) | 2 | | The Binding of Isaac: Rebirth
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| 234. | THE MOST BROKEN LACHRYPHAGY BUILD EVER! (The Binding of Isaac: Repentance) [Lazarus] | 2 | | The Binding of Isaac: Rebirth
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| 235. | CAN'T BELIEVE I DID THIS! (The Binding of Isaac: Repentance) [Azazel] | 2 | | The Binding of Isaac: Rebirth
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| 236. | REMEMBER THE DEFINITION OF INSANITY? (The Binding of Isaac: Repentance) [Delete This Challenge] | 2 | | The Binding of Isaac: Rebirth
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| 237. | These Two Are The Worst (The Binding of Isaac: Repentance) [Jacob & Esau] | 2 | | The Binding of Isaac: Rebirth
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| 238. | TERRIBLE DECISION MAKING (The Binding of Isaac: Repentance) [The Lost] | 2 | | The Binding of Isaac: Rebirth
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| 239. | COMPUTER SAVVY (The Binding of Isaac: Afterbirth+) [166] | 2 | | The Binding of Isaac: Rebirth
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| 240. | THE HARDEST CHARACTER IN REPENTANCE? (The Binding of Isaac: Repentance) [Tainted Eden] | 2 | | The Binding of Isaac: Rebirth
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| 241. | Serpent's Horny Tech (The Binding of Isaac: Repentance) [Apollyon] | 2 | | The Binding of Isaac: Rebirth
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| 242. | AN EXPLOSIVE DOGMA RUN! (The Binding of Isaac: Repentance) | 2 | | The Binding of Isaac: Rebirth
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| 243. | AMAZING RUN, EXCEPT FOR ONE THING (The Binding of Isaac: Repentance) [Isaac] | 2 | | The Binding of Isaac: Rebirth
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| 244. | ISAAC'S LAST HOPE! (The Binding of Isaac: Repentance) [Isaac] | 2 | | The Binding of Isaac: Rebirth
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| 245. | WHEN ISAAC TILTS YOU! (The Binding Of Isaac: Repentance) [Apollyon] | 2 | | The Binding of Isaac: Rebirth
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| 246. | IT'S EASY, JUST DON'T GET HIT! (The Binding of Isaac: Afterbirth+) | 2 | | The Binding of Isaac: Rebirth
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| 247. | TERRIBLE!!! (The Binding of Isaac: Afterbirth+) [121] | 2 | | The Binding of Isaac: Rebirth
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| 248. | This made Tainted Judas Completely Broken (The Binding of Isaac: Repentance) | 2 | | The Binding of Isaac: Rebirth
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| 249. | The First Tainted Samson Run (The Binding of Isaac: Repentance) [Tainted Samson] | 2 | | The Binding of Isaac: Rebirth
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| 250. | It's In The Cards (The Binding of Isaac Afterbirth+) [159] | 2 | Walkthrough | The Binding of Isaac: Rebirth
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| 251. | The Game Could Attempt To Play Nice at Least (The Binding of Isaac: Repentance) [Jacob & Esau] | 2 | | The Binding of Isaac: Rebirth
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| 252. | I DID IT AGAIN! (The Binding of Isaac: Repentance) [Eve] | 2 | | The Binding of Isaac: Rebirth
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| 253. | Repentance Runs | 2 | | The Binding of Isaac: Rebirth
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| 254. | A Wacky Ride (The Binding of Isaac: Repentance) [Tainted Eden] | 2 | | The Binding of Isaac: Rebirth
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| 255. | HOW YOU BEAT MOTHER! (The Binding of Isaac: Repentance) | 2 | Let's Play | The Binding of Isaac: Rebirth
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| 256. | THE STRONGEST EDEN RUN IN REPENTANCE? (The Binding of Isaac: Repentance) | 2 | | The Binding of Isaac: Rebirth
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| 257. | I KNEW I WAS GONNA DO THAT! (The Binding of Isaac: Repentance) [Blue Baby] | 2 | Let's Play | The Binding of Isaac: Rebirth
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| 258. | Brown Nugget Is Broken? (The binding of Isaac: Repentance) [Isaac] | 2 | | The Binding of Isaac: Rebirth
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| 259. | The Binding of Isaac: Afterbirth+ (R095) [RUINED] | 2 | | The Binding of Isaac: Rebirth
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| 260. | THIS IS HOW YOU BEAT THE BEAST! (The Binding of Isaac: Repentance) | 2 | | The Binding of Isaac: Rebirth
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| 261. | WE NEED MORE I-FRAMES! (The Binding Of Isaac: Repentance) | 2 | | The Binding of Isaac: Rebirth
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| 262. | AGAIN (The Binding of Isaac: Afterbirth+) [183] | 2 | Walkthrough | The Binding of Isaac: Rebirth
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| 263. | THE BIGGEST ANGEL ROOM PLAY EVER (The Binding of Isaac: Repentance) [The Lost] | 2 | | The Binding of Isaac: Rebirth
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| 264. | LOOKS LIKE I NEED TO TAKE THE MOTHER PATH MORE! (The Binding of Isaac: Repentance) [Cain] | 2 | | The Binding of Isaac: Rebirth
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| 265. | GREEDY!!! (The Binding of Isaac: Afterbirth+) [117] | 2 | | The Binding of Isaac: Rebirth
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| 266. | Angelic, Sacred, and Immaculate (The Binding of Isaac: Repentance) [Bethany] | 2 | | The Binding of Isaac: Rebirth
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| 267. | THE FIRST TAINTED BETHANY RUN! (The Binding of Isaac: Repentance) [Tainted Bethany] | 2 | | The Binding of Isaac: Rebirth
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| 268. | Isaac Boi. We better than Northernlion (The Binding of Isaac: Afterbirth+) | 2 | | The Binding of Isaac: Rebirth
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| 269. | THE FAMILY MAN! (The Binding of Isaac: Afterbirth+) [178] | 2 | Walkthrough | The Binding of Isaac: Rebirth
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| 270. | I MADE A MISTAKE (The Binding of Isaac: Repentance) [Tainted Eden] | 2 | | The Binding of Isaac: Rebirth
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| 271. | UNLOCKING THE TWINS (The Binding of Isaac: Repentance) [Tainted Lilith] | 2 | | The Binding of Isaac: Rebirth
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| 272. | THESE ARE HIGH LEVEL GAMER FOCUS HOURS! (The Binding of Isaac: Repentance) | 2 | | The Binding of Isaac: Rebirth
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| 273. | Nub Plays Binding of Isaac: Afterbirth+ (R046) [Switch] | 2 | Let's Play | The Binding of Isaac: Rebirth
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| 274. | Playdough Veins (The Binding of Isaac: Repentance) [Blue Baby] | 2 | | The Binding of Isaac: Rebirth
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| 275. | ONE OF THE FASTEST BEAST KILLS I HAVE HAD (The Binding of Isaac: Repentance) | 2 | | The Binding of Isaac: Rebirth
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| 276. | Anxiety Driven Run (The Binding of Isaac: Repentance) | 2 | | The Binding of Isaac: Rebirth
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| 277. | When Life Gives You Lemons (The Binding of Isaac: Afterbirth+) [156] | 2 | | The Binding of Isaac: Rebirth
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| 278. | IT ALL FELL APART! (The Binding of Isaac: Repentance) | 2 | | The Binding of Isaac: Rebirth
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| 279. | THIS RUN IS BOMB AF (The Binding of Isaac: Repentnace) [Jacob And Esau] | 2 | | The Binding of Isaac: Rebirth
|
| 280. | I Almost Messed That Up! (The Binding of Isaac: Repentance) [Eve] | 2 | | The Binding of Isaac: Rebirth
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| 281. | DIRTY MIND (The Binding of Isaac: Repentance) | 2 | | The Binding of Isaac: Rebirth
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| 282. | I'm Tilted (The Binding of Isaac: Repentance) [Eve] | 2 | | The Binding of Isaac: Rebirth
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| 283. | UNLOCKING PLANETARIUMS (The Binding of Isaac: Repentance) | 2 | | The Binding of Isaac: Rebirth
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| 284. | REROLL EXTRAVAGANZA! (The Binding of Isaac: Afterbirth+) | 2 | | The Binding of Isaac: Rebirth
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| 285. | THE STRONGEST SAMSON GREEDIER RUN I'VE EVER HAD! (The Binding of Isaac: Afterbirth+) | 2 | | The Binding of Isaac: Rebirth
|
| 286. | OOF (The Binding of Isaac: Afterbirth+) [163] | 2 | | The Binding of Isaac: Rebirth
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| 287. | THE WORST ROOM IN REPENTANCE? (The Binding of Isaac: Repentance) | 2 | | The Binding of Isaac: Rebirth
|
| 288. | Binding of Isaac Fun | 2 | | The Binding of Isaac: Rebirth
|
| 289. | BLUE BOMBER ATTEMPT 1 (The Binding of Isaac: Afterbirth+) | 2 | | The Binding of Isaac: Rebirth
|
| 290. | It's an Isaac Kind of night | 1 | | The Binding of Isaac: Rebirth
|
| 291. | Sacred Fly Army (The Binding of Isaac: Repentance) [Tainted Apollyon] | 1 | | The Binding of Isaac: Rebirth
|
| 292. | FORFEIT (The Binding of Isaac: Afterbirth+) [161] | 1 | | The Binding of Isaac: Rebirth
|
| 293. | A TERRIBLE DECISION! (The Binding of Isaac: Repentance) [Tainted Lost] | 1 | | The Binding of Isaac: Rebirth
|
| 294. | The Definition of Insanity (The Binding of Isaac: Repentance) [Tainted Lost] | 1 | | The Binding of Isaac: Rebirth
|
| 295. | The Game Reserved all the Damage Ups for this run (The Binding of Isaac: Repentance) [Samson] | 1 | | The Binding of Isaac: Rebirth
|
| 296. | DEPRESSION!! (The Binding of Isaac: Afterbirth+) [119] | 1 | | The Binding of Isaac: Rebirth
|
| 297. | Ashpit (The Binding of Isaac: Repentance) [Bethany] | 1 | | The Binding of Isaac: Rebirth
|
| 298. | HITBOXES NEED FIXED (The Binding of Isaac: Repentance) [Tainted Eden] | 1 | | The Binding of Isaac: Rebirth
|
| 299. | When in Doubt, Abyss Everything (The Binding of Isaac: Repentance) [Tainted Apollyon] | 1 | | The Binding of Isaac: Rebirth
|
| 300. | Making It Work (The Binding of Isaac: Repentance) [Cain] | 1 | | The Binding of Isaac: Rebirth
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