| 1. | Official TBOI Item Guides No. 001: Sad Onion | 12,130 | | The Binding of Isaac
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| 2. | Official TBOI Item Guides No. 002: The Inner Eye | 8,104 | | The Binding of Isaac
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| 3. | Official TBOI Item Guides No. 003: Spoon Bender | 7,731 | | The Binding of Isaac
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| 4. | Official TBOI Item Guides No. 012: Magic Mushroom | 6,688 | | The Binding of Isaac
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| 5. | Official TBOI Item Guides No. 005: My Reflection | 6,021 | | The Binding of Isaac
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| 6. | Official TBOI Item Guides No. 006: Number One | 5,914 | | The Binding of Isaac
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| 7. | Official TBOI Item Guides No. 007: Blood of the Martyr | 5,607 | | The Binding of Isaac
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| 8. | Official TBOI Item Guides No. 008: Brother Bobby | 5,363 | | The Binding of Isaac
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| 9. | Official TBOI Item Guides No. 009: Skatole | 5,300 | | The Binding of Isaac
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| 10. | Official TBOI Item Guides No. 011: 1Up! | 5,115 | | The Binding of Isaac
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| 11. | Official TBOI Item Guides No. 020: Transcendence | 5,013 | | The Binding of Isaac
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| 12. | Official TBOI Item Guides No. 010: Halo of Flies | 4,998 | | The Binding of Isaac
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| 13. | Official TBOI Item Guides No. 013: The Virus | 4,998 | | The Binding of Isaac
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| 14. | Official TBOI Item Guides No. 018: A Dollar | 4,859 | | The Binding of Isaac
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| 15. | Official TBOI Item Guides No. 015: Less Than 3 | 4,768 | | The Binding of Isaac
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| 16. | Official TBOI Item Guides No. 014: Roid Rage | 4,321 | | The Binding of Isaac
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| 17. | Official TBOI Item Guides No. 033: The Bible | 3,938 | | The Binding of Isaac
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| 18. | Official TBOI Item Guides No. 021: The Compass | 3,877 | | The Binding of Isaac
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| 19. | Official TBOI Item Guides No. 029: Mom's Underwear | 3,875 | | The Binding of Isaac
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| 20. | Official TBOI Item Guides No. 169: Polyphemus | 3,828 | | The Binding of Isaac
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| 21. | Official TBOI Item Guides No. 017: Skeleton Key | 3,795 | | The Binding of Isaac
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| 22. | Official TBOI Item Guides No. 028: The Belt | 3,687 | | The Binding of Isaac
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| 23. | Official TBOI Item Guides No. 032: Wire Coat Hanger | 3,622 | | The Binding of Isaac
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| 24. | Official TBOI Item Guides No. 030: Mom's Heels | 3,556 | | The Binding of Isaac
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| 25. | Official TBOI Item Guides No. 034: The Book of Belial | 3,517 | | The Binding of Isaac
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| 26. | Official TBOI Item Guides No. 031: Mom's Lipstick | 3,093 | | The Binding of Isaac
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| 27. | Official TBOI Item Guides No. 092: Super Bandage | 3,040 | | The Binding of Isaac
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| 28. | Official TBOI Item Guides No. 077: My Little Unicorn | 2,921 | | The Binding of Isaac
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| 29. | Official TBOI Item Guides No. 168: Epic Fetus | 2,856 | | The Binding of Isaac
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| 30. | Official TBOI Item Guides No. 101: The Halo | 2,796 | | The Binding of Isaac
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| 31. | Official TBOI Item Guides No. 153: Mutant Spider | 2,794 | | The Binding of Isaac
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| 32. | Official TBOI Item Guides No. 152: Technology 2 | 2,716 | | The Binding of Isaac
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| 33. | Official TBOI Item Guides No. 096: Little C.H.A.D. | 2,670 | | The Binding of Isaac
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| 34. | Official TBOI Item Guides No. 095: Robo-Baby | 2,565 | | The Binding of Isaac
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| 35. | Official TBOI Item Guides No. 094: Sack of Pennies | 2,505 | | The Binding of Isaac
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| 36. | Official TBOI Item Guides No. 093: The Gamekid | 2,494 | | The Binding of Isaac
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| 37. | Official TBOI Item Guides No. 151: The Mulligan | 2,287 | | The Binding of Isaac
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| 38. | Official TBOI Item Guides No. 099: Little Gish | 2,203 | | The Binding of Isaac
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| 39. | Official TBOI Item Guides No. 170: Daddy Longlegs | 2,167 | | The Binding of Isaac
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| 40. | Official TBOI Item Guides No. 154: Chemical Peel | 2,095 | | The Binding of Isaac
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| 41. | Official TBOI Item Guides No. 179: Fate | 2,091 | | The Binding of Isaac
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| 42. | Official TBOI Item Guides No. 159: Spirit of the Night | 2,076 | | The Binding of Isaac
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| 43. | Official TBOI Item Guides No. 161: Ankh | 2,069 | | The Binding of Isaac
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| 44. | Official TBOI Item Guides No. 166: The D20 | 2,030 | | The Binding of Isaac
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| 45. | Official TBOI Item Guides No. 173: Mitre | 1,951 | | The Binding of Isaac
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| 46. | Official TBOI Item Guides No. 157: Bloody Lust | 1,943 | | The Binding of Isaac
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| 47. | Official TBOI Item Guides No. 156: Habit | 1,942 | | The Binding of Isaac
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| 48. | Official TBOI Item Guides No. 158: Crystal Ball | 1,937 | | The Binding of Isaac
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| 49. | Official TBOI Item Guides No. 164: The Candle | 1,916 | | The Binding of Isaac
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| 50. | Official TBOI Item Guides No. 155: The Peeper | 1,888 | | The Binding of Isaac
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| 51. | Official TBOI Item Guides No. 160: Crack the Sky | 1,798 | | The Binding of Isaac
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| 52. | Official TBOI Item Guides No. 163: Ghost Baby | 1,744 | | The Binding of Isaac
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| 53. | Official TBOI Item Guides No. 258: Missing No. | 1,741 | | The Binding of Isaac
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| 54. | Official TBOI Item Guides No. 167: Harlequin Baby | 1,733 | | The Binding of Isaac
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| 55. | Official TBOI Item Guides No. 261: Proptosis | 1,690 | | The Binding of Isaac
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| 56. | Official TBOI Item Guides No. 162: Celtic Cross | 1,688 | | The Binding of Isaac
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| 57. | Official TBOI Item Guides No. 171: Spider Butt | 1,676 | | The Binding of Isaac
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| 58. | Official TBOI Item Guides No. 172: Sacrificial Dagger | 1,526 | | The Binding of Isaac
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| 59. | Official TBOI Item Guides No. 200: Mom's Eyeshadow | 1,484 | | The Binding of Isaac
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| 60. | Official TBOI Item Guides No. 194: Magic 8 Ball | 1,434 | | The Binding of Isaac
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| 61. | Official TBOI Item Guides No. 259: Dark Matter | 1,289 | | The Binding of Isaac
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| 62. | Official TBOI Item Guides No. 260: Black Candle | 1,128 | | The Binding of Isaac
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| 63. | Official TBOI Item Guides No. 254: Blood Clot | 934 | | The Binding of Isaac
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