| 1. | The Binding of Isaac: Afterbirth Release Date Teaser | 520,989 | | The Binding of Isaac: Rebirth
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| 2. | The Binding of Isaac Rebirth Teaser Trailer | 451,231 | | The Binding of Isaac: Rebirth
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| 3. | The Binding of Isaac: Rebirth Release Date Trailer | 409,522 | | The Binding of Isaac: Rebirth
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| 4. | The Binding of Isaac: Repentance Launch Trailer | 326,267 | | The Binding of Isaac: Rebirth
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| 5. | The Binding of Isaac: Afterbirth+ Release Date Trailer | 316,165 | | The Binding of Isaac: Rebirth
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| 6. | The Binding of Isaac: Afterbirth Release Trailer | 296,911 | Preview | The Binding of Isaac: Rebirth
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| 7. | Isaac Repentance | 183,916 | | The Binding of Isaac: Rebirth
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| 8. | The Binding of Isaac: Afterbirth+ The Forgotten Update | 160,892 | Vlog | The Binding of Isaac: Rebirth
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| 9. | RemiLore (Switch, PS4, Xbox One, Steam) Announcement Trailer! | 91,090 | | The Binding of Isaac: Rebirth
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| 10. | The Binding of Isaac: Repentance Physical Edition Teaser Trailer | 78,090 | | The Binding of Isaac: Rebirth
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| 11. | Nintendo Switch The Binding of Isaac: Afterbirth+ Announcement Trailer | 66,938 | | The Binding of Isaac: Rebirth
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| 12. | The Binding of Isaac Repentance+ Beta Release Trailer | 57,681 | | The Binding of Isaac: Rebirth
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| 13. | The Binding of Isaac: Rebirth on Wii U Gamepad Preview | 35,618 | | The Binding of Isaac: Rebirth
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| 14. | The Binding of Isaac: Repentance Physical Edition Teaser Trailer Updated | 32,768 | | The Binding of Isaac: Rebirth
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| 15. | The Binding of Isaac: Repentance New Teaser Trailer | 26,641 | | The Binding of Isaac: Rebirth
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| 16. | The Binding of Isaac: Afterbirth+ PlayStation 4 Release Date Announcement Trailer | 16,920 | Let's Play | The Binding of Isaac: Rebirth
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| 17. | The Binding of Isaac: Afterbirth PS4 pre-release Livestream | 14,828 | | The Binding of Isaac: Rebirth
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| 18. | The Binding of Isaac: Afterbirth+ Xbox One Launch Trailer | 14,420 | | The Binding of Isaac: Rebirth
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| 19. | Crystal Crisis Original Soundtrack: Ballos Theme | 13,271 | | The Binding of Isaac: Rebirth
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| 20. | The Binding of Isaac: Afterbirth+ Coming to Xbox One | 11,700 | | The Binding of Isaac: Rebirth
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| 21. | 1001Spikes New Challengers | 10,079 | | The Binding of Isaac: Rebirth
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| 22. | Official TBOI Item Guides No. 004: Cricket's Head | 10,059 | | The Binding of Isaac: Rebirth
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| 23. | RemiLore Developer Video 2: Gameplay System and Modes | 8,524 | | The Binding of Isaac: Rebirth
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| 24. | Official TBOI Item Guides Nos. 022-026, 346, 456, 707 - Meals | 5,661 | | The Binding of Isaac: Rebirth
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| 25. | Official TBOI Item Guides No. 149: Ipecac | 5,416 | | The Binding of Isaac: Rebirth
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| 26. | Official TBOI Item Guides No. 052: Dr. Fetus | 5,050 | | The Binding of Isaac: Rebirth
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| 27. | Official TBOI Item Guides No. 027: Wooden Spoon | 5,009 | | The Binding of Isaac: Rebirth
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| 28. | Official TBOI Item Guides No. 050: Steven | 4,952 | | The Binding of Isaac: Rebirth
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| 29. | Official TBOI Item Guides No. 064: Steam Sale | 4,492 | | The Binding of Isaac: Rebirth
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| 30. | Official TBOI Item Guides No. 049: Shoop Da Whoop! | 4,472 | | The Binding of Isaac: Rebirth
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| 31. | Official TBOI Item Guides No. 051: Pentagram | 4,432 | | The Binding of Isaac: Rebirth
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| 32. | Official TBOI Item Guides No. 118: Brimstone | 4,432 | | The Binding of Isaac: Rebirth
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| 33. | Official TBOI Item Guides No.019: Boom! | 4,282 | | The Binding of Isaac: Rebirth
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| 34. | Official TBOI Item Guides No. 069: Chocolate Milk | 4,233 | | The Binding of Isaac: Rebirth
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| 35. | Official TBOI Item Guides No. 105: The D6 | 4,224 | | The Binding of Isaac: Rebirth
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| 36. | Official TBOI Item Guides No. 042: Bob's Rotten Head | 4,216 | | The Binding of Isaac: Rebirth
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| 37. | Official TBOI Item Guides No. 068 Technology | 4,154 | | The Binding of Isaac: Rebirth
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| 38. | Official TBOI Item Guides No. 036: The Poop | 4,074 | | The Binding of Isaac: Rebirth
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| 39. | Official TBOI Item Guides No. 075: PHD | 3,960 | | The Binding of Isaac: Rebirth
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| 40. | Official TBOI Item Guides No. 056: Lemon Mishap | 3,893 | | The Binding of Isaac: Rebirth
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| 41. | Official TBOI Item Guides No. 046: Lucky Foot | 3,884 | | The Binding of Isaac: Rebirth
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| 42. | Official TBOI Item Guides No. 060: The Ladder | 3,857 | | The Binding of Isaac: Rebirth
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| 43. | Official TBOI Item Guides No. 055: Mom's Eye | 3,816 | | The Binding of Isaac: Rebirth
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| 44. | Official TBOI Item Guides No. 073: Cube of Meat | 3,729 | | The Binding of Isaac: Rebirth
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| 45. | Official TBOI Item Guides No. 081: Dead Cat | 3,727 | | The Binding of Isaac: Rebirth
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| 46. | Official TBOI Item Guides No. 182: Sacred Heart | 3,697 | | The Binding of Isaac: Rebirth
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| 47. | Official TBOI Item Guides No. 114: Mom's Knife | 3,685 | | The Binding of Isaac: Rebirth
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| 48. | Official TBOI Item Guides No. 062: Charm of the Vampire | 3,680 | | The Binding of Isaac: Rebirth
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| 49. | Official TBOI Item Guides No. 057: Distant Admiration | 3,676 | | The Binding of Isaac: Rebirth
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| 50. | Official TBOI Item Guides No. 048: Cupid's Arrow | 3,667 | | The Binding of Isaac: Rebirth
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| 51. | Official TBOI Item Guides No. 040: Kamikaze! | 3,645 | | The Binding of Isaac: Rebirth
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| 52. | Official TBOI Item Guides No. 074: A Quarter | 3,645 | | The Binding of Isaac: Rebirth
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| 53. | Official TBOI Item Guides No. 038: Tammy's Head | 3,614 | | The Binding of Isaac: Rebirth
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| 54. | Official TBOI Item Guides No. 044: Teleport! | 3,584 | | The Binding of Isaac: Rebirth
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| 55. | Official TBOI Item Guides No. 063: The Battery | 3,542 | | The Binding of Isaac: Rebirth
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| 56. | Official TBOI Item Guides No. 072: Rosary | 3,514 | | The Binding of Isaac: Rebirth
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| 57. | Official TBOI Item Guides No. 080: The Pact | 3,503 | | The Binding of Isaac: Rebirth
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| 58. | Official TBOI Item Guides No. 070: Growth Hormones | 3,484 | | The Binding of Isaac: Rebirth
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| 59. | Official TBOI Item Guides No. 079: The Mark | 3,459 | | The Binding of Isaac: Rebirth
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| 60. | Official TBOI Item Guides No. 035: The Necronomicon | 3,419 | | The Binding of Isaac: Rebirth
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| 61. | Official TBOI Item Guides No. 045: Yum Heart | 3,417 | | The Binding of Isaac: Rebirth
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| 62. | Official TBOI Item Guides No. 053: Magneto | 3,414 | | The Binding of Isaac: Rebirth
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| 63. | Official TBOI Item Guides No. 037: Mr. Boom | 3,410 | | The Binding of Isaac: Rebirth
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| 64. | Official TBOI Item Guides No. 054: Treasure Map | 3,367 | | The Binding of Isaac: Rebirth
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| 65. | Official TBOI Item Guides No. 047: Doctor's Remote | 3,367 | | The Binding of Isaac: Rebirth
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| 66. | Official TBOI Item Guides No. 058: Book of Shadows | 3,364 | | The Binding of Isaac: Rebirth
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| 67. | Official TBOI Item Guides No. 039: Mom's Bra | 3,317 | | The Binding of Isaac: Rebirth
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| 68. | Official TBOI Item Guides No. 076: X-Ray Vision | 3,312 | | The Binding of Isaac: Rebirth
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| 69. | Official TBOI Item Guides No. 090: The Small Rock | 3,287 | | The Binding of Isaac: Rebirth
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| 70. | Official TBOI Item Guides No. 071: Mini Mush | 3,287 | | The Binding of Isaac: Rebirth
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| 71. | Official TBOI Item Guides No. 067: Sister Maggy | 3,277 | | The Binding of Isaac: Rebirth
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| 72. | Official TBOI Item Guides No. 104: The Parasite | 3,266 | | The Binding of Isaac: Rebirth
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| 73. | Official TBOI Item Guides No. 082: Lord of the Pit | 3,203 | | The Binding of Isaac: Rebirth
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| 74. | Official TBOI Item Guides No. 108: The Wafer | 3,195 | | The Binding of Isaac: Rebirth
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| 75. | Official TBOI Item Guides No.041: Mom's Pad | 3,122 | | The Binding of Isaac: Rebirth
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| 76. | Official TBOI Item Guides No. 150: Tough Love | 3,122 | | The Binding of Isaac: Rebirth
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| 77. | Official TBOI Item Guides No. 165: Cat-O-Nine-Tails | 3,092 | | The Binding of Isaac: Rebirth
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| 78. | Official TBOI Item Guides No. 065: Anarchist Cookbook | 3,071 | | The Binding of Isaac: Rebirth
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| 79. | Official TBOI Item Guides No. 078 Book of Revelations | 3,040 | | The Binding of Isaac: Rebirth
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| 80. | Official TBOI Item Guides No. 127: Forget Me Now | 3,034 | | The Binding of Isaac: Rebirth
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| 81. | Official TBOI Item Guides No. 083: The Nail | 2,944 | | The Binding of Isaac: Rebirth
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| 82. | Official TBOI Item Guides No. 100: Little Steven | 2,864 | | The Binding of Isaac: Rebirth
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| 83. | Official TBOI Item Guides No. 087: Loki's Horns | 2,841 | | The Binding of Isaac: Rebirth
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| 84. | Official TBOI Item Guides 066: The Hourglass | 2,821 | | The Binding of Isaac: Rebirth
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| 85. | Official TBOI Item Guides No. 146: Prayer Card | 2,817 | | The Binding of Isaac: Rebirth
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| 86. | Official TBOI Item Guides No. 109: Money = Power | 2,814 | | The Binding of Isaac: Rebirth
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| 87. | Official TBOI Item Guides No. 091: Spelunker Hat | 2,798 | | The Binding of Isaac: Rebirth
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| 88. | Official TBOI Item Guides No. 086: Monstro's Tooth | 2,788 | | The Binding of Isaac: Rebirth
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| 89. | Official TBOI Item Guides No. 132: A Lump Of Coal | 2,783 | | The Binding of Isaac: Rebirth
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| 90. | Official TBOI Item Guides No. 121: Odd Mushroom | 2,744 | | The Binding of Isaac: Rebirth
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| 91. | Official TBOI Item Guides No. 088: Little Chubby | 2,728 | | The Binding of Isaac: Rebirth
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| 92. | Official TBOI Item Guides No. 117: Dead Bird | 2,728 | | The Binding of Isaac: Rebirth
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| 93. | Official TBOI Item Guides No. 089: Spider Bite | 2,726 | | The Binding of Isaac: Rebirth
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| 94. | Official TBOI Item Guides No. 122: Whore of Babylon | 2,717 | | The Binding of Isaac: Rebirth
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| 95. | Official TBOI Item Guides No. 085: Deck of Cards | 2,712 | | The Binding of Isaac: Rebirth
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| 96. | Official TBOI Item Guides No. 112: Guardian Angel | 2,710 | | The Binding of Isaac: Rebirth
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| 97. | Official TBOI Item Guides No. 119: Blood Bag | 2,665 | | The Binding of Isaac: Rebirth
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| 98. | Official TBOI Item Guides No. 120: Odd Mushroom | 2,617 | | The Binding of Isaac: Rebirth
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| 99. | Official TBOI Item Guides No. 116: 9 Volt | 2,502 | | The Binding of Isaac: Rebirth
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| 100. | Official TBOI Item Guides No. 141: Pageant Boy | 2,493 | | The Binding of Isaac: Rebirth
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