| 1. | Usagisquared Plays | 67 | Usagisquared Plays Alien: Isolation - Ep 32 | 29:41 |
| 2. |  Eneija | 51 | Let's Play Alien: Isolation EP55 // STAIRWAY TO HAPPINESS [FINALE] | 26:41 |
| 3. |  Eversor Fatalis | 49 | Let's Play Alien Isolation: Part 49 | 42:36 |
| 4. | GamerGirls | 46 | Alien Isolation Episode 44 - Back to the Beginning | 34:43 |
| 5. | Lavinia | 41 | The End -Ep 41 Let's Play: Alien Isolation | 22:26 |
| 6. |  Gab Smolders | 37 | [ Alien: Isolation ] 2nd Playthrough on HARD MODE - FINAL | 1:53:09 |
| 7. | lilly waters | 32 | Get 'er Done Lets Play: Alien Isolation Part 37 | 37:36 |
| 8. | Liara Gaming | 27 | Running from the androids in Alien Isolation #shorts | 0:53 |
| 9. | GamerKat09 | 18 | (P4) Let's Play - Perception [BLIND] - Surrounded by Dolls | 1:24:20 |
| 10. | Liera | 12 | ENDING - Playing Alien Isolation For the First Time l Hard Mode - Pt.14 | 59:36 |
| 11. |  GirlFromAus | 11 | Alien Isolation Playthrough Part 11 - An Insane Ending | 1:18:39 |
| 12. | DoubleDamsels | 6 | Double Damsels Play | Alien: Isolation | Part 8 | Two Weeks From Retirement | 10:23 |
| 13. | Meghan Yeah | 6 | Alien: Isolation - Part 6 - Walkthrough / Playthrough / Let's Play | 5:39:30 |
| 14. | Celina VODs | 3 | Will I Survive This? - Alien: Isolation (Full Playthrough Part 6) | 6:12:01 |
| 15. | AssassinGlasgow | 3 | A Couple Let's Plays: Alien Isolation | ALIENS, ANDROIDS, NOOOOO [Pt. 3] | 15:04 |
| 16. | Unbealievable | 3 | Livestream Archive \\ Let's Play Alien: Isolation w/ My Girlfriend Janome \\ STOP BREATHING #3 | 1:32:16 |
| 17. |  8 Bites | 2 | ALIEN ISOLATION BONUS EPISODE - Last Survivor | 20:23 |
| 18. | More2Me 4Life | 2 | Alien Isolation Nightmare Challenge With Sound Alerts (2/2) | 6 Years on YouTube | Lets Play | 6:16:11 |
| 19. | Nashtya Newb | 2 | Nash plays her trap card in ALIEN: ISOLATION | Part 33 | 40:45 |
| 20. | 39daph vods | 2 | 39daph Plays Alien: Isolation - Part 2 (Final) | 7:41:48 |
| 21. |  My Cinnamon Phoe | 1 | Phoephoe plays Alien: Isolation Nightmare Mode - Part 21 | 21:02 |
| 22. | Girls Play | 1 | DO YOU WANT TO PLAY A GAME? | Girls Play | Captured Alpha | 25:47 |
| 23. | Angel Alyx | 1 | HAPPY LATE HALLOWEEN | Alien Isolation LIVE | 3:40:04 |
