| 1. |  88 Plays | 100,167 | Let's Play Atelier Sophie: The Alchemist of the Mysterious Book - Part 87 - Ending | 18:54 |
| 2. |  Leomedes | 33,777 | Let's Play Atelier Sophie #116 Latter Days 6 | 22:07 |
| 3. |  TheTwitGamer | 31,615 | Atelier Sophie (PS4, Blind, Let's Play) | Latter Days DLC 1/3 | Part 34 | 36:08 |
| 4. |  Karsten's Chronicle | 27,797 | Let's Play Atelier Sophie - 72: Anticlimactic Climax (Story End) | 43:54 |
| 5. |  ARNOTS GAMING | 19,620 | Atelier Sophie - "The Story Begins" Gameplay Trailer - PS4, PS3, & PS Vita [Japan] | 2:10 |
| 6. | MasterLL | 10,672 | 「Atelier Sophie」 Playthrough Final Day 11 ~ "End of Alchemy" (TTV) | 3:06:04 |
| 7. | DaverRaver | 10,222 | Let's Play: Atelier Sophie - Part 25 [A Cozy Ending] | 50:26 |
| 8. | Handheld Players | 7,424 | Atelier Sophie: The Alchemist of The Mysterious Book PS Vita Let's Play Gameplay #4 (PS Vita/PS4) | 19:51 |
| 9. | Bumpy McSquigums | 4,207 | Let's Play Atelier Sophie: The Alchemist Of The Mysterious Book DX - Part 3 - Don't Die! | 37:29 |
| 10. | Fudce | 3,757 | Atelier Sophie - Episode 81: Homecoming | 20:18 |
| 11. | MrThatKid4 | 2,857 | Let's Play Atelier Sophie Part 26.5: Moving Towards Completion | 49:11 |
| 12. |  Kulture GamIng | 2,018 | Atelier Sophie The Alchemist of The Mysterious Book - Let's Play #2 - Au cœur de l'aventure ! | 37:47 |
| 13. | Rice Digital | 1,997 | Let's Play Atelier Sophie #3: Lots of Wheat (First Hour) | 23:34 |
| 14. | RANDROID | 1,910 | Let's Play Atelier Sophie - Part 10 - Sophie Hates Political Correctness | 29:06 |
| 15. | JPGames | 1,471 | Atelier Sophie: The Alchemist of the Mysterious Book Gameplay - Deutsch / German | PS4 | 2:06:29 |
| 16. | HackNSlacker | 1,452 | Atelier Sophie DX - Investigating Pamela's real age and crafting new recipes | 43:24 |
| 17. | ZeroPingBlood | 1,373 | Ma 1ère Fois - Atelier Sophie : The Alchemist of the Mysterious Book | GAMEPLAY | 34:02 |
| 18. | R3D Gaming | 1,270 | Early November 2016 Pickups | 5:03 |
| 19. | RPGs Sphere (Sashalina) | 877 | 『 DLC ● Latter Days Episode 』 Atelier Sophie: The Alchemist of the Mysterious Book ~ FR | 1:30:43 |
| 20. | JacksawJack | 851 | Let's Play Atelier Sophie: The Alchemist and the Mysterious Journey (Finale) | 1:05:48 |
| 21. | Ashenn | 430 | Atelier Sophie ~The Alchemist of the Mysterious Book~ 「Logy」 Help Collect Materials Ingot | 1:38 |
| 22. | PrimeraEspada91 | 406 | Atelier Sophie ~The Alchemist of the Mysterious Book Dx~ Despair Playthrough Part 10 | 47:22 |
| 23. | Gilko EnVtuber | 299 | We become OP! - [Atelier Sophie: The Alchemist of the Mysterious Book DX] - Finale | 3:50:04 |
| 24. | Kaitoucchi | 212 | Atelier Sophie: The Alchemist of the Mysterious Book DX - PC Playthrough Part 2 | 21:28 |
| 25. | Kairu | Deku Scrub | 181 | Atelier Sophie (Live Desktop Wallpaper) [Wallpaper Engine] | 1:35 |
| 26. | YuyuYT | 179 | Atelier Sophie Post Game Gameplay w/ Yuyu Part 51 - Helping Meklet and Atomina? | 29:44 |
| 27. | MegamanNG | 171 | MegamanNG's First Hour Gameplay – Atelier Sophie: The Alchemist of the Mysterious Book DX | 1:00:46 |
| 28. | Fréd老人。 | 157 | Lets play Atelier Sophie :D #13 Twin dragons | 2:17:59 |
| 29. | Back Turned Legend | 117 | Nyah plays Atelier Sophie part 3 | 2:33:41 |
| 30. | GeekyTwins | 110 | Atelier Sophie #66 - Help Oskar, Fight a Dragon and Death | 42:01 |
| 31. | Jhanz | 102 | Jhanz Plays: Atelier Sophie The Alchemist of the Mysterious Book DX [Pt.8] [Final] | 2:33:12 |
| 32. | Stoic | 101 | Lucky 7 | Atelier Sophie: The Alchemist of the Mysterious Book | Part 7 | 52:46 |
| 33. |  Verociel | 84 | Atelier Sophie: The Alchemist of the Mysterious Book (PC Gameplay) | MAGIC! | Vero Tries | 41:21 |
| 34. | OnPSX | 83 | Atelier Sophie: The Alchemist of the Mysterious Book - Official Trailer (PS4, Vita) | 1:37 |
| 35. | WatchhawkZeroTwo | 79 | Ep. 35 - Helping out Logy - Let's Play Atelier Sophie | 1:08:49 |
| 36. | DLH | 63 | Atelier Sophie Platinum Playthrough part 11 (Finale) | 7:27:13 |
| 37. |  Arashi Saga | 58 | Let's Play Atelier Sophie DX Part 6 - No commentary | 2:58:07 |
| 38. | CatAngel | 57 | Atelier Sophie The Alchemist of the Mysterious Book Playthrough Part 8 Leon and a mysterious girl | 20:15 |
| 39. | NeoDrao | 51 | Atelier Sophie DX (PS4) silent stream: slightly blind playthrough | 7:05:35 |
| 40. | AtticusMJ Plays | 44 | Atelier Sophie The Alchemist Of The Mysterious Book 44 Final Boss & Ending | 1:10:43 |
| 41. | Byuukai | 41 | GP「 ソフィーのアトリエ|Atelier Sophie」(PS4) ~ Part 6: Saved in the last second | 18:43 |
| 42. | RadConsoleGaming | 35 | RadConsoleGaming Plays Atelier Sophie: The Alchemist of the Mysterious Book (PS4) | 2:07:23 |
| 43. |  Aru Dark Shinobi | 33 | Atelier Sophie "Synthesis Bottled Misfortune -Visiting all friends -Mision: Help Oskar 1& 2" [PC]#36 | 54:06 |
| 44. | Miyah Rinkusu | 32 | Let's Play Atelier Sophie: The Alchemist of the Mysterious Book! #4 | 1:44:58 |
| 45. | Tinman | 32 | Atelier Sophie #05 - Helping out | 46:28 |
| 46. | Schrient | 32 | Atelier Sophie the Alchemist of the Mysterious Book DX Part 13: Quest and No Rest! | 38:21 |
| 47. | Seichi Ryuune | 30 | Let's Play Together: Atelier Sophie ~ The Alchemist of the Mysterious Book ~ [06] Clothes | 3:03:56 |
| 48. | Epicboy | 29 | Atelier Sophie The Alchemist of the Mysterious Book Logy is a Blacksmith? #3 | 15:00 |
| 49. | British-Weeb | 28 | Let's Play Atelier Sophie: Ep 16 Hope Recipes | 40:16 |
| 50. | Genbu Ch. | 25 | [atelier Sophie] pls help idk what I'm doing | 39:57 |
| 51. |  Anniv Games Lab. | 25 | [錬72]EXTRA初視聴－ソフィーのアトリエ初見実況/Atelier Sophie FirstPlaythrough 72[アトリエシリーズ25周年 / Atelier 25th Anniv.] | 28:40 |
| 52. | Yohanes Aditya | 25 | Atelier Sophie: The Alchemist of the Mysterious Book Playthrough Part 5.5 | 11:54:59 |
| 53. | Recordstopia | 24 | Continuista, pero perfecto para adentrarse en la saga - Probando Atelier Sophie en Playstation 5 | 30:56 |
| 54. | flowerpower | 22 | First Playthrough - Atelier Sophie - 12? PostGame Time Traveling | 5:21:23 |
| 55. | Shatteredmana | 19 | Let's Play Atelier Sophie Part 2 | 30:34 |
| 56. | Hobbiesroom | 19 | Atelier Sophie The Alchemist of the Mysterious Book - Les 30 premières minutes sur Playstation 4 | 34:38 |
| 57. | mythimago | 17 | Searching for the Tuned Cauldron - Atelier Sophie #10 (Blind Playthrough) | 11:08 |
| 58. | McDoub | 17 | Let's Play Atelier Sophie The Alchemist of the Mysterious Book Part 2 | 30:27 |
| 59. | osLive | 14 | JP00028 p0001 ソフィーのアトリエ ～不思議な本の錬金術士～ First Playthrough PS Plus Challenge! | 50:17 |
| 60. | MultiSt3p | 12 | Atelier Sophie The Alchemist of The Mysterious Book Playthrough Part6 | 5:12 |
| 61. | C0dedem0n | 10 | Atelier Sophie: The Alchemist of the Mysterious Book DX Playthrough Part 1 (PS5) | 1:09:29 |
| 62. | weaslTV | 10 | Atelier Sophie Playthrough - Part 2 | 16:10 |
| 63. | TK plays | 9 | Alese412 plays Atelier Sophie part 2 | 38:16 |
| 64. |  Helltio Everygames | 9 | Inside The Box Episode 34 - Atelier Sophie The Alchemist Of The Mysterious Book Playstation 4 | 3:18 |
| 65. | Al Games Review | 6 | Atelier Sophie The Alchemist of the Mysterious Book - PlayStation Vita | 22:07 |
| 66. | SelfieDestructSystem | 5 | Atelier Sophie Playthrough Pt. 1 | 2:31:20 |
| 67. | JaydeXMicky | 4 | Let's play Atelier Sophie The Alchemist of the Mysterious Book part 1 1/2 | 3:57:04 |
| 68. | André | 2 | Blue Reflection PS4 PlayStation 4 | 2:15 |
| 69. | Wolpertinger-hime | 1 | Starting Atelier Sophie!: Wolpertinger-hime VOD Sept 7, 2022 | 3:01:17 |
| 70. | Mark Carpenter | 1 | Atelier Sophie: Helping the People and Plachta | 2:47:43 |
| 71. | Medagame | 0 | Nuevo Trailer de Atelier Sophie en consolas PlayStation | 1:22 |
