| 1. |  Sips | Big Pharma (PC - First Look/Gameplay) - An Evening With Sips | 256,285 | First Impressions |
| 2. |  CRYSTAL | СОЗДАЙ СВОЮ МЕДИЦИНУ! | 214,715 | |
| 3. | quill18 | Let's Make Drugs: Big Pharma #1 | 200,386 | |
| 4. | CRYSTAL | ЗАРАБОТАЙ ДЕНЬГИ НА ЛЕКАРСТВАХ! | 183,748 | |
| 5. | EnterElysium | Big Pharma Needs You #01 [Acne] - Let's Play | 157,386 | Let's Play |
| 6. | CRYSTAL | ЛЕКАРСТВА ЭТО БИЗНЕС! | 147,797 | |
| 7. | Generikb | "HERMITECH™ MAKING DRUGS!!!" - Big Pharma Part 01 - 1080p HD PC Gameplay Walkthrough | 133,870 | Walkthrough |
| 8. | Northernlion | Let's Look At: Big Pharma! | 99,131 | |
| 9. |  Debitor | Ich stelle ab jetzt Drogen her | 89,870 | |
| 10. | quill18 | Let's Make Drugs: Big Pharma #2 | 88,269 | |
| 11. | EnterElysium | Big Pharma Needs You #02 [Female Contraceptive] - Let's Play | 73,519 | Let's Play |
| 12. | CRYSTAL | СОЗДАЁМ СВОИ ЛЕКАРСТВА! - Big Pharma | 65,572 | |
| 13. | EnterElysium | Big Pharma Marketing and Malpractice #01 I AM MARTIN SHKRELI - Let's Play | 62,805 | Let's Play |
| 14. | EnterElysium | Big Pharma Needs You #03 [Erectile Disfunction] - Let's Play | 62,162 | Let's Play |
| 15. |  Upper Echelon | Industrialized Medical Fraud - Big Pharma and a Perverse Government | 61,274 | |
| 16. | Generikb | "GET OUT GOUT!!!" - Big Pharma Part 02 - 1080p HD PC Gameplay Walkthrough | 58,715 | Walkthrough |
| 17. | quill18 | Let's Make Drugs: Big Pharma #3 | 57,381 | |
| 18. | quill18 | Let's Make Drugs: Big Pharma #4 | 57,379 | |
| 19. | Gadarol | Big Pharma #1 EINFACH GEIL! Erste Schritte Der Pillen Fabrik Simulator BETA Gameplay deutsch | 56,207 | |
| 20. | EnterElysium | Big Pharma Needs You #04 [Bipolar] - Let's Play | 55,672 | Let's Play |
| 21. | Generikb | "DRUGS...SHAKEN NOT STIRRED!!!" - Big Pharma Part 03 - 1080p HD PC Gameplay Walkthrough | 55,042 | Walkthrough |
| 22. | CRYSTAL | ЗАРАБАТЫВАЕМ МИЛЛИОН ЛЕКАРСТВАМИ! - Big Pharma | 49,902 | |
| 23. | Worth A Buy | Big Pharma Review - Worth a Buy? | 47,521 | Review |
| 24. | Generikb | "#1 DRUG MAKER IN THE WORLD!!!" - Big Pharma Part 04 - 1080p HD PC Gameplay Walkthrough | 45,804 | Walkthrough |
| 25. | CRYSTAL | СОЗДАЕМ НОВЫЕ ЛЕКАРСТВА! - Big Pharma | 45,773 | |
| 26. | EnterElysium | Big Pharma Needs You #05 [Insomnia] - Let's Play | 44,325 | Let's Play |
| 27. |  Azehara Ch | Pippa on Big Pharma | 39,811 | |
| 28. | EnterElysium | Big Pharma Needs You #06 [Liver Disease] - Let's Play | 33,884 | Let's Play |
| 29. | EnterElysium | Big Pharma Needs You #07 [Malaria] - Let's Play | 33,736 | Let's Play |
| 30. | EnterElysium | Big Pharma #01 [Insomnia] Megacure - Let's Play | 33,168 | Let's Play |
| 31. | PhoenixRZN | Big Pharma. Прохождение с Русским Комментатором (видео 1) | 31,559 | |
| 32. | EnterElysium | Big Pharma Marketing and Malpractice #02 - Let's Play | 31,247 | Let's Play |
| 33. | Chiches | Big Pharma - Chiches y la Fábrica de Drogas - #1 en español | 30,719 | |
| 34. | GOG | Big Pharma Trailer | 30,714 | |
| 35. | Generikb | "I'VE LOST MY APPETITE!!!" - Big Pharma Part 05 - 1080p HD PC Gameplay Walkthrough | 30,401 | Walkthrough |
| 36. |  Samed Güngör | İlk İzlenim : Big Pharma | 28,357 | |
| 37. |  MaxPalaro | Jogando Big Pharma com Max #1 | 27,333 | Let's Play |
| 38. | Etalyx | Big Pharma - Medicine Building Sim! | 25,895 | |
| 39. | Skye Storme | Big Pharma Part 1 ►The Basics for Success!◀ Tutorial/Beta Gameplay | 25,823 | Tutorial |
| 40. |  pingvinharcos | Big Pharma - Igen, ez egy játék, ahol gyógyszert gyártunk. | 25,426 | |
| 41. | Steejo | Let's Play Big Pharma Part 1 - Gameplay Introduction | 25,400 | Let's Play |
| 42. | Csonti Gaming | Első látásra | Big Pharma | 24,737 | |
| 43. | EnterElysium | Big Pharma #02 [Asthma] Megacure - Let's Play | 23,673 | Let's Play |
| 44. | Первый Хоррор Канал | Big Pharma Прохождение На Русском — СИМУЛЯТОР ПРОИЗВОДСТВА ЛЕКАРСТВ | 22,663 | |
| 45. | EnterElysium | Big Pharma #01 [Hyperthyroidism] Cornering the Low End - Let's Play | 22,133 | Let's Play |
| 46. | docm77 | HOW TO MAKE DRUGS - Big Pharma Gameplay E01 | Docm77 | 21,815 | Guide |
| 47. |  Ace Combat Fan | Pixy got a new job in BIG PHARMA! | 21,728 | |
| 48. | EnterElysium | Big Pharma Marketing and Malpractice #03 - Let's Play | 21,696 | Let's Play |
| 49. | tom.io | Big Pharma - Intermediate - Level 1 - Folge 1 [ Deutsch / German / Let´s Play ] | 21,603 | |
| 50. | EnterElysium | Big Pharma [Evil Drugs Company Sim] - Beta Impressions | 21,078 | |
| 51. | EnterElysium | Big Pharma #03 [Appetite Suppressant] Megacure - Let's Play | 20,966 | Let's Play |
| 52. | EnterElysium | Big Pharma #04 [Irritable Bowel Syndrome] Megacure - Let's Play | 20,863 | Let's Play |
| 53. | VoodyGames | СИМУЛЯТОР ФАРМАЦЕВТА! | 20,709 | |
| 54. | HypnotoadProductions | BIG PHARMA #001 - Squab Merl Co ★ Let's Play Big Pharma [HD][1080p 60FPS] | 19,991 | Let's Play |
| 55. | Gadarol | Big Pharma #2 Am Rande des Ruins Der Pillen Fabrik Simulator BETA Gameplay | 19,600 | |
| 56. | MetalBear | Big Pharma #01 "Medicamento Manipulado" - Gameplay Português Vamos Jogar PT-BR | 19,391 | |
| 57. | EnterElysium | Big Pharma Marketing and Malpractice #04 - Let's Play | 19,190 | Let's Play |
| 58. | Pinstar | Big Pharma Strategy & Tactics 1: The Agressive Hipster Opener | 16,918 | |
| 59. | EnterElysium | Big Pharma #01 [Female Contraceptive] Money Spinners - Let's Play | 16,400 | Let's Play |
| 60. | EnterElysium | Big Pharma Marketing and Malpractice #05 - Let's Play | 15,649 | Let's Play |
| 61. | WeaselZone | Big Pharma - HOW TO MAKE DRUGS - Overview & Tutorial ★ Let's Play Big Pharma | 15,295 | Tutorial |
| 62. | Gadarol | Big Pharma #3 gute Marge böse Kredite Der Pillen Fabrik Simulator BETA Gameplay | 15,172 | |
| 63. |  Nathan's Sandbox | Big Pharma: Ep. #1 - SELLING DRUGS -= Gameplay & Walkthrough =- | 14,640 | Walkthrough |
| 64. | Pravus | Steamed! | Big Pharma | 13,955 | |
| 65. | HypnotoadProductions | BIG PHARMA #002 - Moar Money? ★ Let's Play Big Pharma [HD][1080p 60FPS] | 13,931 | Let's Play |
| 66. | EnterElysium | Big Pharma Marketing and Malpractice #06 - Let's Play | 13,875 | Let's Play |
| 67. | Aavak | Big Pharma 1 *First Taste* - Misery Money | 13,653 | |
| 68. | EnterElysium | Big Pharma #02 [ADHD] Cornering the Low End - Let's Play | 13,600 | Let's Play |
| 69. | Skye Storme | Big Pharma Part 2 ►Upgrade Drugs for Big Cash!◀ Tutorial/Beta Gameplay | 13,132 | Tutorial |
| 70. | Rahmschnitzel | Let's Play | Big Pharma [#01] - Tutorialmeisterspieler Rahm macht Kopfschmerzen - Let's Play | 12,983 | Let's Play |
| 71. | Chiches | Big Pharma - Chiches y la Fábrica de Drogas - #2 en español | 12,944 | |
| 72. | docm77 | LOSING WEIGHT WITH DRUGS - Big Pharma Gameplay E02 | Docm77 | 12,887 | |
| 73. | Gadarol | Big Pharma #4 Den Platz gut nutzen Der Pillen Fabrik Simulator BETA Gameplay | 12,862 | |
| 74. | EnterElysium | Big Pharma #04 [EVERYTHING] Cornering the Low End - Let's Play | 12,595 | Let's Play |
| 75. | Nathan's Sandbox | Big Pharma: Ep. #14 - THE 6'000$ CURE -= Gameplay & Walkthrough =- | 12,297 | Walkthrough |
| 76. | TheNoobsKanal | Wie geht das denn alles? - Big Pharma #01 [German Deutsch Lets Play] | 12,264 | |
| 77. | Yippee Ki Yay Mr Falcon | Let's Play Big Pharma - Dick Fungal Wart Punisher - Part 1 [Big Pharma Gameplay] | 12,193 | Let's Play |
| 78. | EnterElysium | Big Pharma Marketing and Malpractice #07 - Let's Play | 12,108 | Let's Play |
| 79. | Steejo | Let's Play Big Pharma Part 2 | 11,994 | Let's Play |
| 80. | tom.io | Checkliste: Big Pharma (beta) [ Deutsch / German ] | 11,620 | |
| 81. | docm77 | BIG MONEY PRODUCTS Part 1 - Big Pharma Gameplay E04 | Docm77 | 11,291 | |
| 82. | EnterElysium | Big Pharma Marketing and Malpractice #08 - Let's Play | 11,184 | Let's Play |
| 83. | EnterElysium | Big Pharma #03 [Bipolar] Cornering the Low End - Let's Play | 11,019 | Let's Play |
| 84. | EnterElysium | Big Pharma #08 [Male Contraceptive] Money Spinners - Let's Play | 10,918 | Let's Play |
| 85. | ZigTheHedge | [Запись стрима] Big Pharma - Зиг - варить! | 10,846 | |
| 86. | Pinstar | Big Pharma Guide: Mastering The Multi-Mixer | 10,817 | Guide |
| 87. | PhoenixRZN | Big Pharma. Прохождение с Русским Комментатором (видео 2) | 10,280 | |
| 88. | EnterElysium | Big Pharma Marketing and Malpractice #09 - Let's Play | 10,266 | Let's Play |
| 89. | Pinstar | Big Pharma Strategy & Tactics 1: Dealing With Sucky Ingrediants | 9,959 | |
| 90. | HypnotoadProductions | BIG PHARMA #003 - Stopocux Eaticus ★ Let's Play Big Pharma [HD][1080p 60FPS] | 9,910 | Let's Play |
| 91. | docm77 | ADVANCED DRUGS & MIXER TUTORIAL - Big Pharma Gameplay E03 | Docm77 | 9,858 | Tutorial |
| 92. | EnterElysium | Big Pharma #02 [Asthma] Money Spinners - Let's Play | 9,726 | Let's Play |
| 93. | AlMoDi - обзоры игр и техники | Подробный обзор Big Pharma AlMoDi | 9,552 | |
| 94. | MaxPalaro | Jogando Big Pharma com Max #2 | 9,533 | Let's Play |
| 95. | Negative Root | Big Pharma 1 Drug Production 101 | 9,228 | |
| 96. | Gadarol | Big Pharma #5 Den Creamer freigschalten Der Pillen Fabrik Simulator BETA Gameplay | 9,095 | |
| 97. | EnterElysium | Big Pharma #03 [Erectile Dysfunction] Money Spinners - Let's Play | 8,976 | Let's Play |
| 98. | EnterElysium | Big Pharma #04 [Appetite Suppressant] Money Spinners - Let's Play | 8,933 | Let's Play |
| 99. | tom.io | Big Pharma - Intermediate - Level 1 - Folge 2 [ Deutsch / German / Let´s Play ] | 8,841 | |
| 100. | Stuff+ | Preview + Big Pharma [Beta] | 8,777 | Let's Play |
