| 1. |  NileRed | Extracting caffeine from caffeine pills | 3,600 | |
| 2. |  The Style Theorists | Can Caffeine Beauty Products ENERGIZE You? | Style Theory | 2,900 | |
| 3. | TopTenz | Caffeine is More Like an Illegal Drug Than You Realized... | 1,900 | |
| 4. | More Plates More Dates | Here’s How Alphas Take 875 Mg Of Caffeine... | 1,423 | Let's Play |
| 5. | ElectricShock | HOW MUCH G-FUEL CAN YOU DRINK? - TALKING ABOUT CAFFEINE! | 876 | |
| 6. | Dark Box | Caffeine Fever [FNAF SL Comic] comic by Blustreakgirl | 730 | |
| 7. | MinuteEarth | How Caffeine Accidentally Took Over The World | 614 | |
| 8. |  Simon Miller | 5 INCREDIBLE Things That Happened When I GAVE UP CAFFEINE | Better Gym Pumps! Better Recovery! | 595 | |
| 9. | CaRtOoNz | MY PIGEONS EXPLODE NOW?! | Bum Sim | 509 | |
| 10. | TC9700Gaming | Caffeine and Octane | Nakai San, LSX Willys and More! | 410 | |
| 11. | BBC Earth Science | Is Drinking Caffeine Good Or Bad For You? | Earth Lab | 373 | |
| 12. |  alanzoka | CAFFEINE DEMO - MONSTRO DO CAFÉ? | 370 | |
| 13. | Doctor ER | ER Doctor DEBUNKS 8 Caffeine Myths! | 342 | |
| 14. |  Circle People | Rafis | Syaro(CV.Uchida Maaya) - Caffeine Fighter [Kilimanjaro] HDHRDT 98.64% FC 705pp | 258 | |
| 15. | Simon Miller | CAFFEINE! 5 Ways It’s GREAT For Working Out And 5 Ways It SUCKS! | 238 | |
| 16. | Khanvolution | RWBY Volume 2 Chapter 12 REACTION: Breach! CAFFEINE!! | 223 | |
| 17. | Dexerto | Logan Defends Prime after Canada BAN | 222 | Vlog |
| 18. | G FUEL | G FUEL ORANGE | CAFFEINE FREE | 201 | |
| 19. |  Fedupsamania | Caffeine / Episode 1 - Bölüm 2 (SON) / Kahve Canavarı!!? [HD] | 169 | Show |
| 20. | John Wolfe | CAFFEINE - In Space No One Can Hear You Yawn | 168 | |
| 21. |  GuitarHeroStyles | DAILY LEVEL #85 | Geometry Dash 2.1 - "Caffeine Mastah" by Usermatt18 | GuitarHeroStyles | 152 | |
| 22. | BBC Earth Science | The Effect Of Caffeine On Your Heart | Earth Lab | 148 | |
| 23. | Fedupsamania | Caffeine / Episode 1 - Bölüm 1 / Kahve Alır Mıydınız? [HD] | 135 | Show |
| 24. | Khanvolution | RWBY Vol. 2 Soundtrack REACTION Part 2: Sacrifice that Caffeine!! | 125 | Review |
| 25. |  PietSmietTV | React: Best Fails of the Week! Too Much Caffeine! | 103 | |
| 26. | Circle People | Cookiezi | Syaro(CV.chida Maaya) - Caffeine Fighter [Kilimanjaro] HDHRDT 99.14% 783/921 1xmiss 655pp | 94 | |
| 27. | Tomohawk | Important Announcements Vlog - Youtube, Caffeine.tv, New Channel, Life | 83 | Vlog |
| 28. | BBC Earth Science | How Does Caffeine Affect You? | Earth Lab | 80 | |
| 29. |  Chan 2j | How to Make a Tiger Caffeine Milk Ice Creamวิธีทํา Tiger Caffeine เป็นไอศกรีมนมแสนอร่อย | 79 | Guide |
| 30. | generic purple protogen | A Protogen Plays Changed Special Edition on Caffeine part 4 (LIVE) | 52 | |
| 31. | G FUEL | Caffeine Free G FUEL Orange | World Reveal | 51 | |
| 32. | Pandorya | CAFFEINE - Ruckelige Fail-Action irgendwo im Weltraum ● Let's Play Caffeine | 50 | Let's Play |
| 33. |  Jeto | I'm an Idiot and I'm sorry! | My Caffeine Overdose | 48 | Show |
| 34. | Esports Talk | 100 Thieves Investor Drake Joins FaZe Offset and JuJu on Caffeine | 46 | |
| 35. | JAC OneManBand | RWBY Review: Caffeine Breakdown | 45 | Review |
| 36. | ManlyBadassHero | Caffeine - A Future Ruled By Coffee;Demo, Manly Let's Play | 43 | Let's Play |
| 37. |  Coach Jazz | The Effects Of Energy Drinks And Caffeine On Your Gaming Performance! | 43 | |
| 38. | generic purple protogen | A Protogen Plays Changed Special Edition on Caffeine part 2 (LIVE) | 42 | |
| 39. |  LucikkaPelailee | Demonurkkaus - Caffeine! [Pre-Alpha] | 41 | Let's Play |
| 40. | generic purple protogen | (new update) A Protogen Plays Changed Special Edition on Caffeine part 6 (LIVE) | 41 | |
| 41. | DivideAConquergaming | IM BACK! Where Did I Go? Check Out Caffeine! | 40 | |
| 42. | GameSprout | Too Much Caffeine! (Game Fails #414) | 38 | |
| 43. | JD Coffee | Caffeine & Consoles | We PLAY often with FRIENDS! | 37 | |
| 44. | Korey | Low on caffeine Quest Guide AQW 2016 /join dreamforest | 37 | Guide |
| 45. | generic purple protogen | A Protogen Plays Changed Special Edition on Caffeine part 5 (LIVE) | 37 | |
| 46. |  RockLeeSmile | Indie Impressions - Caffeine (Preview Build) | 36 | Preview |
| 47. |  Vinceff | Ubuntu Gaming 22.04 LTS ! Simple, performant et stable ! | 35 | |
| 48. | theScore esports | They Put CAFFEINE In Noodles?? | 34 | |
| 49. |  ISH News | Caffeine: Friend or Enemy? | ISH News | 34 | |
| 50. | club4ghz | Unreal Engine 4 - Caffeine Tech Demo - GTX 780 Ti | 33 | |
| 51. | PricePlow | FDA Wants to BAN Concentrated Caffeine! But... | 33 | |
| 52. | Screambox | Adam Plays Caffeine - SPACE COFFEE | 31 | Let's Play |
| 53. | PkmnMasterHolly | Burn Out & Caffeine [DAY 6/7] | 30 | |
| 54. | G FUEL | Caffeine-Free Energy | G FUEL Orange | 29 | |
| 55. | FemslashYuri4All | ♥Coco Adel x Velvet Scarlatina - RWBY - Caffeine♥ | 28 | |
| 56. | Pat Stares At | Pat Stares At FF14 Job Action Live Letter! + Special Guest Caffeine! | 26 | |
| 57. | Chahat Anand | Caffeine Se Neend Kyn Nahi Aati ? | Pros and Cons of Caffines | @ChahatAnand | 24 | |
| 58. | Asia Does Stuff. | Run. (Part 2 of Charles on Caffeine) | 24 | |
| 59. | EverydayFoodReviews | Rockstar XDurance 200mg 25% more Caffeine?! Blueberry, Pomegranate and Acai energy drink review | 23 | Review |
| 60. | Daniel Kapadia | How To Use CAFFEINE & L-THEANINE To Get In The ZONE! | 23 | Guide |
| 61. | ShezLifts | I Quit Caffeine, Was It Even Worth It? (Caffeine Withdrawal Timeline) | 23 | |
| 62. | generic purple protogen | A Protogen Plays Deer Simulator On Caffeine (LIVE) | 22 | |
| 63. | PhuCat103 | dP.T: Dr Pepper Terror | CAFFEINE HORROR (All Endings) | 22 | |
| 64. | Chahat Anand | How Does Caffeine Keep you Awake? | Chahat Anand #shorts | 21 | |
| 65. | Manga 303 | Caffeine OS 840 Reloaded ( Amiga ) | 21 | |
| 66. | markeedragon | Must Find Caffeine! Dr. Pepper in Iceland? - Markee Dragon IRL | 20 | |
| 67. | Moomin Littlesocks | WHO DIS? IT'S CAFFEINE! | 20 | |
| 68. | generic purple protogen | A Protogen Plays Changed Special Edition on Caffeine part 3 (LIVE) | 20 | |
| 69. | Mister Cloud | First batch of caffeine gummies! 50 mg each! #gummy #caffeine #food #energy | 20 | |
| 70. | Rock Paper Shotgun | Caffeine Doesn't Start So Well | 20 | |
| 71. | Falky | WHY & HOW I Quit CAFFEINE! (Energy Drinks) | 20 | |
| 72. | SquallDawg | My Brutally Honest Review of Caffeine.tv | 19 | Review |
| 73. | PC Games Hardware | Caffeine | Demo zum Horror-Thriller mit Unreal Engine 4 | 19 | |
| 74. | EverydayFoodReviews | Oshee Vitamin Caffeine Water and Watermelon Ice Effect Energy Drink Review | 19 | Review |
| 75. | Jr Pro TV | PRIME Energy From Caffeine | Finish Your Drink Before 1738 #short | 18 | |
| 76. | splicerslayer129 | Mr. Bubbles and his little sister: Episode 5 "Caffeine" | 17 | |
| 77. |  Zio Garbe | Il caffè è il miglior amico delle nottate su MTG ft. Caffeine Lily [in risposta scombo mtg podcast] | 17 | Show |
| 78. | Puffin | when the caffeine kicks in... | 17 | |
| 79. | Coffee & Reactions | Doctors Debunk 13 Caffeine Myths | Debunked Reaction | 16 | |
| 80. | generic purple protogen | FIRST Stream of the Year! Protogen chatting on caffeine! (Live) | 16 | |
| 81. | RonnRetrobro jr | Rertrobro's Columbus Day Special! | 16 | |
| 82. | BadBobbyGamer BBG | Biohazard Coffee 928 MG Caffeine Review | 16 | Review |
| 83. | PaderGamez | Caffeine - Indie Horror Game - Sehr viel Potential! | 16 | |
| 84. | NintendoBrew | Nintendo Switch: Warmboot-Exploit "caffeine" ermöglicht CFW auf gepatchten Systemen [Deutsch|HD] | 15 | |
| 85. | MoneyGlitchGod | ME & RONNIE2K SQUAD UP & PULL UP ON HIS BIGGEST HATERS IN PARK AND THIS HAPPENED!!! | 15 | |
| 86. | Rich Tomorrow | I'm Buzzed Off Caffeine. Come Chat With Me. | 15 | |
| 87. | Vandalia1998 | Talking Time with Caffeine - #NETWORKING (Talking Time with Caffeine S1 E6) | 15 | |
| 88. | Absbb Gaming | So, I may have made my friends overdose on caffeine... featuring Eastinanddopey (funny moments) | 15 | |
| 89. | generic purple protogen | Protogen chatting on caffeine! (Live) | 14 | |
| 90. | Naomi Kyle | OMGitsfirefoxx on Bus Simulator & Making Our Tongues Turn Blue! | 14 | |
| 91. | thechinamuffin | Does Caffeine Make You Better at Gaming? #gamingshorts #caffeine | 14 | |
| 92. | EverydayFoodReviews | Rockstar 200mg Punched Guava and Supersours Bubbleburst - More Caffeine, More Flavour? | 14 | Review |
| 93. | Sloppy's Pc Gaming & Benchmarks | CAFFEINE A SCI- FI HORROR GAME* UNREAL ENGINE 4* RADEON 295X2 | 14 | |
| 94. | Manga 303 | Caffeine OS 834 ( Amiga ) | 14 | |
| 95. | CazaKnighty | The Simpsons Hit And Run Walkthrough - Level 5 Mission 1: Incriminating Caffeine | 14 | Walkthrough |
| 96. | generic purple protogen | Protogen chatting on caffeine! (Live) | 14 | |
| 97. | JayBratt | A Discussion on CAFFEINE... | 13 | Discussion |
| 98. | Naomi Kyle | Who Makes the Best Burger & Borderlands w/ Britanni Johnson | 13 | |
| 99. | NICO VTR | HONDA CB 750 CAFE RACER - CAFFEINE CUSTOM - CB750K 1979 LIMITED EDITION | 13 | |
| 100. | The Resident Evil AMC | Oh Great My Caffeine Headache Really Bad | 13 | |
