| 1. |  special edd | We Cried. Too Sad. [It Takes Two] [#7] | 2,396,684 | |
| 2. | SSundee | IM ADDICTED TO THIS GAME (It Takes Two) | 2,142,224 | |
| 3. | special edd | We did the big succ [It Takes Two] | 1,666,176 | |
| 4. | Zifan Play | It Takes Two All Bosses [No Damage] With Cutscenes + Ending | 1,622,213 | |
| 5. | special edd | We CRIED together. [It Takes Two] [END] | 1,533,196 | |
| 6. | special edd | When she says "Nail Me, Daddy" [It takes two] [#2] | 1,470,370 | |
| 7. | special edd | We're falling apart [It Takes Two] [#8] | 1,429,986 | |
| 8. | Girlfriend Reviews | Should couples play It Takes Two? | Girlfriend Reviews | 1,393,248 | Review |
| 9. | LilyPichu | it takes two with michael :D pt. 1 | 1,355,238 | |
| 10. | special edd | She needs a BONK! [It Takes Two] [#11] | 1,335,526 | |
| 11. | MoreMemeGod | FIGHTING A GIANT VACUUM MONSTER (It Takes Two) | 1,189,717 | |
| 12. | special edd | She's had enough [It Takes Two] [#6] | 1,184,916 | |
| 13. | special edd | She saw the BIG PP! [It Takes Two] [#5] | 1,173,828 | |
| 14. | special edd | Don't laugh like this. [It Takes two] [#3] | 1,155,465 | |
| 15. | IGN | It Takes Two Review | 1,150,836 | Review |
| 16. | VTubers | IT TAKES TWO! We're Addicted To This Game! Let's Play Combo Panda & Alpha Lexa! | 1,147,559 | Let's Play |
| 17. | berleezy | A CO-OP DIVORCE SIMULATOR (w/ @Storymodebae) | It Takes Two - Part 1 | 1,089,927 | |
| 18. | special edd | We Touched Tips [It Takes Two] [#9] | 1,048,359 | |
| 19. | special edd | She Did the Thing - [It Takes Two] [#4] | 1,000,253 | |
| 20. | MoreMemeGod | FIGHTING A GIANT TOOLKIT MONSTER (It Takes Two) | 986,195 | |
| 21. | gameranx | Top 10 NEW Games of 2021 [FIRST HALF] | 930,582 | |
| 22. | LilyPichu | It Takes Two /w Michael :D pt 2 | 918,556 | |
| 23. | Jacob Alpharad | It Takes Two with Jaiden | 909,235 | |
| 24. | special edd | We Switched Places (bad idea) [It Takes Two] [#10] | 906,595 | |
| 25. | Hollow | It Takes Two - Part 1 - This Game is INCREDIBLE.. | 892,004 | Walkthrough |
| 26. | GamingWithJen | It Takes Two: INSANE VACUUM BOSS FIGHT + BOOK ANNOUNCEMENT!! | 881,229 | |
| 27. | Kai Cenat Live | We Played It Takes Two! | 875,982 | |
| 28. | LilyPichu | It Takes Two pt 3 /w Michael and Space Winston | 844,283 | |
| 29. | LilyPichu | It Takes Two FINAL!! Ft. Michael Reeves | 778,052 | |
| 30. | FA GAMEZ | It Takes Two (PS5) 4K 60FPS HDR Gameplay | 758,858 | |
| 31. | meGAME | Phân Tích Game: It Takes Two - Chắc Chắn Game Of The Year 2021 | meGAME | 724,305 | |
| 32. | LilyPichu | It Takes Two pt 6 Ft Michael Reeves | 704,278 | |
| 33. | MoreMemeGod | ENTERING A GIANT BEEHIVE (It Takes Two) | 696,230 | |
| 34. | gameranx | 10 SURPRISE HITS of 2021 | 692,373 | |
| 35. | meGAME | [OFFICIAL] VIDEO Xin Lỗi EA - Anh Bạn À... | meGAME | 676,428 | |
| 36. | special edd | The "Green Card" Song [It Takes Two] [#12] | 662,602 | |
| 37. | IGN | Split Fiction - Official Gameplay Reveal Trailer | The Game Awards 2024 | 643,592 | |
| 38. | GameGrumps | Trauma with TOYS - It Takes Two | 616,299 | |
| 39. | Alienx Mongolia | ТӨСӨӨЛШГҮЙ ТОГЛООМЫН ЕРТӨНЦ | It Takes Two EP-6 | w/@Ulaangamer | 563,890 | |
| 40. | Video Detective | It Takes Two Trailer 1995 | 559,472 | Preview |
| 41. | Neebs Gaming | It Takes Two Full Playthrough: Part One | 514,399 | Let's Play |
| 42. | Motown Deep Cuts, PAMS Jingles & More with Tomovox | "Motown Greatest Hits" "Marvin Gaye and Kim Weston- It Takes Two" | 505,013 | |
| 43. | Logitech G | Best New Co-op Games To Play | 475,885 | |
| 44. | GameGrumps | When all you have is a hammer - It Takes Two | 439,098 | |
| 45. | The Escapist | It Takes Two (Zero Punctuation) | 438,525 | |
| 46. | berleezy | CAN THIS MARRIAGE BE SAVED?! (w/ @Storymodebae) | It Takes Two - Part 2 | 429,688 | |
| 47. | PlayStation | It Takes Two – Official Gameplay Trailer | PS5, PS4 | 408,914 | Preview |
| 48. | Its Shatter | It Takes Two is Dark.. (Cutie the Elephant Death Scene) | 401,093 | |
| 49. | Titi Toys and Dolls | Barbie It Takes Two School Morning & Camping Trip with Dolls | 394,420 | |
| 50. | MOGE Gaming | ТӨГСӨВ w/ @AlienxMongolia | It Takes Two Ep.11 | 381,762 | |
| 51. | GameGrumps | Ugh, I can't get any flipping SPATULAGE - It Takes Two | 381,480 | |
| 52. | berleezy | THIS GAME TOOK A DARK TURN... (w/ @Storymodebae) | It Takes Two - Part 3 | 379,467 | |
| 53. | JazzyGuns | CAN WE DO THIS??? | It Takes Two w/@DwayneKyng | Part 1 | 378,555 | |
| 54. | Maka91Productions | It Takes Two - 100% Achievements/Trophies & All 25 Minigames Locations Guide | 374,471 | Guide |
| 55. | Dunk Tank | Dunk and Leah play It Takes Two | 365,393 | |
| 56. | GameGrumps | A goo-shootin' good time! - It Takes Two | 363,469 | |
| 57. | loltyler1 | TYLER1: IT TAKES TWO WITH MACAIYLA PART 2 | 362,875 | |
| 58. | berleezy | WE STRUGGLING TO CO-OPERATE!! (w/ @Storymodebae) | It Takes Two - Part 4 | 361,656 | |
| 59. | Shoto's Twitch VODs | 【3/19/2022】IT TAKES TWO BRAINCELLS 【It Takes Two ft. Vox Part 1】 | 359,913 | |
| 60. | Neebs Gaming | It Takes Two Full Playthrough: Part Two | 350,739 | Let's Play |
| 61. | MOGE Gaming | ГИШГЭХ ГАЗАР АЛГА w/ @AlienxMongolia | It Takes Two Ep.05 | 349,207 | |
| 62. | Alienx Mongolia | РОБОТ СОНО + GOKU + САНСАР | It Takes Two EP-4 | w/ @Ulaangamer | 346,261 | |
| 63. | berleezy | ARE WE FINALLY GETTING ALONG?! (w/ @Storymodebae) | It Takes Two - Part 5 | 341,882 | |
| 64. | Alienx Mongolia | ЯЛААНЫ ЗОВЛОН | It Takes Two EP-2 | w/@Ulaangamer | 338,344 | |
| 65. | loltyler1 | TYLER1: IT TAKES TWO WITH MACAIYLA | 334,872 | |
| 66. | Mithzan | It Takes Two | Chapter Three | 329,492 | |
| 67. | MOGE Gaming | ГАЙХАМШИГТ ЕРТӨНЦ w/ @AlienxMongolia | It Takes Two Ep.07 | 311,287 | |
| 68. | GameGrumps | Goo Grumps enter the Squirrel Cave of Wonders! - It Takes Two | 303,892 | |
| 69. | Titi Toys and Dolls | Barbie It Takes Two Doll Pet Adventure Story | 295,572 | |
| 70. | Alienx Mongolia | ГЭЗЭГНИЙ ҮЗҮҮРЭЭР ХАТНЫГ... | It Takes Two EP-10 | w @Ulaangamer | 291,859 | |
| 71. | special edd | It Takes Two in SPACE! w/Gabby | 291,800 | |
| 72. | GameGrumps | Back by semi-popular demand! | It takes two [7] | 287,218 | |
| 73. | Hollow | It Takes Two - Part 3 - IM ADDICTED TO THIS GAME | 285,813 | Walkthrough |
| 74. | GameGrumps | We are smol bean with DANGEROUS GOO! - It Takes Two | 285,166 | |
| 75. | SeeReax | It Takes Two Idiots | 282,951 | |
| 76. | Akryl1kz | PS5 Officially Revealed! Do NOT Buy Digital Version! | 277,844 | |
| 77. | GameGrumps | Flame, death, and BABOONY BUTTS! | It Takes Two [8] | 273,746 | |
| 78. | The Co-op Company | It Takes Two Friends Pass - How To and Requirements | 269,622 | Guide |
| 79. | PlayStation | It Takes Two - The Game Awards 2020: Official Reveal Trailer | PS5, PS4 | 267,444 | |
| 80. | Alienx Mongolia | ЦАГААР НААДАГСАД МӨСӨН ХОТХОНД | It Takes Two EP-8 | w@Ulaangamer | 260,889 | |
| 81. | Altrive Plus | I want a divorce | 255,648 | |
| 82. | MOGE Gaming | ЯАГААД БАЙГААМ БЭ? w/ @AlienxMongolia | It Takes Two Ep.03 | 245,741 | |
| 83. | GameGrumps | Death by rubber ducky!!! | It Takes Two [10] | 243,179 | |
| 84. | Gamer's Little Playground | Unravel Ending 1080p 60FPS HD | 237,998 | |
| 85. | MOGE Gaming | ЦАСАН БӨМБӨЛӨГ w/ @AlienxMongolia | It Takes Two Ep.09 | 233,071 | |
| 86. | JazzyGuns | LET'S GET THIS RIGHT!!! | It Takes Two w/ @DwayneKyng | Part 2 | 231,567 | |
| 87. | GameGrumps | Don't forget to turn off the BALLS!!! | It Takes Two [9] | 227,389 | |
| 88. | GameGrumps | Ugh, we HATE hurting cute things! | It Takes Two [11] | 217,992 | |
| 89. | thegameawards | THE GAME AWARDS 2021: It Takes Two wins Game Of The Year | 217,060 | |
| 90. | GameGrumps | Dangit Farmer Arin, don't doink the cows! | It Takes Two [12] | 216,264 | |
| 91. | JazzyGuns | COLLABORATION!!! | It Takes Two w/ @DwayneKyng Gameplay!! | ENDING!!! | 214,766 | |
| 92. | Decent Pretzel | Kronii & Kaela Get Competitive, even in a co-op game #shorts | 209,317 | |
| 93. | PlayStation | It Takes Two – Official Launch Trailer | PS5, PS4 | 209,193 | |
| 94. | JazzyGuns | WHERE IS THE LOVE??? | It Takes Two w/ @DwayneKyng | Part 3 | 206,194 | |
| 95. | 神戳戳的苏神 | 《双人成行》全面评测，一个字：太值了！ | 205,466 | |
| 96. | Shoto's Twitch VODs | 【3/31/2022】ENEMIES TO LOVERS SLOW BURN ARC【Shoto | It Takes Two /w Vox Part 2】 | 202,885 | |
| 97. | Parsec | How to Play It Takes Two Online | 202,633 | Tutorial |
| 98. | Rhymestyle | WE COULDNT STOP LAUGHING! It Takes Two Idiots Episode 2 | 195,827 | Show |
| 99. | Hollow | It Takes Two - Part 2 - MOON BABOON BOSS FIGHT | 193,926 | Walkthrough |
| 100. | Hollow | It Takes Two - Part 4 - ITS ALL OVER 🙁 (ENDING) | 188,195 | Walkthrough |
