| 1. |  special edd | We CRIED together. [It Takes Two] [END] | 4,763 | |
| 2. | Akryl1kz | PS5 Officially Revealed! Do NOT Buy Digital Version! | 4,666 | |
| 3. | SSundee | IM ADDICTED TO THIS GAME (It Takes Two) | 4,467 | |
| 4. | berleezy | A CO-OP DIVORCE SIMULATOR (w/ @Storymodebae) | It Takes Two - Part 1 | 3,262 | |
| 5. | special edd | We Cried. Too Sad. [It Takes Two] [#7] | 3,195 | |
| 6. | GamingWithJen | It Takes Two: INSANE VACUUM BOSS FIGHT + BOOK ANNOUNCEMENT!! | 3,000 | |
| 7. | special edd | She saw the BIG PP! [It Takes Two] [#5] | 2,488 | |
| 8. | special edd | She needs a BONK! [It Takes Two] [#11] | 2,422 | |
| 9. | special edd | She Did the Thing - [It Takes Two] [#4] | 2,305 | |
| 10. | special edd | The "Green Card" Song [It Takes Two] [#12] | 2,248 | |
| 11. | Girlfriend Reviews | Should couples play It Takes Two? | Girlfriend Reviews | 2,207 | Review |
| 12. | special edd | We did the big succ [It Takes Two] | 2,135 | |
| 13. | special edd | We're falling apart [It Takes Two] [#8] | 1,971 | |
| 14. | special edd | Don't laugh like this. [It Takes two] [#3] | 1,967 | |
| 15. | GameGrumps | Trauma with TOYS - It Takes Two | 1,875 | |
| 16. | gameranx | Top 10 NEW Games of 2021 [FIRST HALF] | 1,822 | |
| 17. | meGAME | [OFFICIAL] VIDEO Xin Lỗi EA - Anh Bạn À... | meGAME | 1,800 | |
| 18. | special edd | We Touched Tips [It Takes Two] [#9] | 1,739 | |
| 19. | special edd | She's had enough [It Takes Two] [#6] | 1,739 | |
| 20. | special edd | We Switched Places (bad idea) [It Takes Two] [#10] | 1,611 | |
| 21. | special edd | When she says "Nail Me, Daddy" [It takes two] [#2] | 1,573 | |
| 22. | berleezy | CAN THIS MARRIAGE BE SAVED?! (w/ @Storymodebae) | It Takes Two - Part 2 | 1,567 | |
| 23. | berleezy | ARE WE FINALLY GETTING ALONG?! (w/ @Storymodebae) | It Takes Two - Part 5 | 1,267 | |
| 24. | thegameawards | THE GAME AWARDS 2021: It Takes Two wins Game Of The Year | 1,260 | |
| 25. | Neebs Gaming | It Takes Two Full Playthrough: Part One | 1,234 | Let's Play |
| 26. | LilyPichu | It Takes Two pt 3 /w Michael and Space Winston | 1,197 | |
| 27. | GameGrumps | Back by semi-popular demand! | It takes two [7] | 1,195 | |
| 28. | berleezy | THIS GAME TOOK A DARK TURN... (w/ @Storymodebae) | It Takes Two - Part 3 | 1,173 | |
| 29. | Its Shatter | It Takes Two is Dark.. (Cutie the Elephant Death Scene) | 1,151 | |
| 30. | berleezy | WE STRUGGLING TO CO-OPERATE!! (w/ @Storymodebae) | It Takes Two - Part 4 | 1,142 | |
| 31. | IGN | It Takes Two Review | 1,112 | Review |
| 32. | LilyPichu | it takes two with michael :D pt. 1 | 1,095 | |
| 33. | Neebs Gaming | It Takes Two Full Playthrough: Part Two | 1,063 | Let's Play |
| 34. | GameGrumps | When all you have is a hammer - It Takes Two | 1,004 | |
| 35. | MOGE Gaming | ТӨГСӨВ w/ @AlienxMongolia | It Takes Two Ep.11 | 1,003 | |
| 36. | GameGrumps | Goo Grumps enter the Squirrel Cave of Wonders! - It Takes Two | 978 | |
| 37. | LilyPichu | It Takes Two FINAL!! Ft. Michael Reeves | 978 | |
| 38. | GameGrumps | Ugh, we HATE hurting cute things! | It Takes Two [11] | 955 | |
| 39. | meGAME | Phân Tích Game: It Takes Two - Chắc Chắn Game Of The Year 2021 | meGAME | 938 | |
| 40. | SeeReax | It Takes Two Idiots | 923 | |
| 41. | Hollow | It Takes Two - Part 1 - This Game is INCREDIBLE.. | 868 | Walkthrough |
| 42. | LilyPichu | It Takes Two /w Michael :D pt 2 | 854 | |
| 43. | gameranx | 10 SURPRISE HITS of 2021 | 847 | |
| 44. | OneyPlays | IT TAKES TWO | 846 | Let's Play |
| 45. | MoreMemeGod | FIGHTING A GIANT VACUUM MONSTER (It Takes Two) | 846 | |
| 46. | GameGrumps | A goo-shootin' good time! - It Takes Two | 783 | |
| 47. | GameGrumps | Dangit Farmer Arin, don't doink the cows! | It Takes Two [12] | 781 | |
| 48. | SeeReax | It Takes Two Idiots To Finish The Game | 752 | |
| 49. | LilyPichu | It Takes Two pt 6 Ft Michael Reeves | 750 | |
| 50. | GameGrumps | Flame, death, and BABOONY BUTTS! | It Takes Two [8] | 737 | |
| 51. | MOGE Gaming | ЯАГААД БАЙГААМ БЭ? w/ @AlienxMongolia | It Takes Two Ep.03 | 685 | |
| 52. | GameGrumps | Ugh, I can't get any flipping SPATULAGE - It Takes Two | 675 | |
| 53. | AfroSenju XL | Easily The Best Co-op Game I've Played (EXCLUSIVE It Takes Two Early Gameplay) | 658 | |
| 54. | GameGrumps | We are smol bean with DANGEROUS GOO! - It Takes Two | 636 | |
| 55. | Rhymestyle | It Takes Two Idiots To Sing WUTIZGOINEVRY | 615 | |
| 56. | The Escapist | It Takes Two (Zero Punctuation) | 581 | |
| 57. | Peshawa Barznji | 😍خەڵاتی باشترینەکانی ساڵ ئینجا سەیر کەن چ یارییەک بەڕێوەیە وەی | 549 | |
| 58. | MOGE Gaming | ГАЙХАМШИГТ ЕРТӨНЦ w/ @AlienxMongolia | It Takes Two Ep.07 | 542 | |
| 59. | special edd | It Takes Two in SPACE! w/Gabby | 524 | |
| 60. | PlayStation | It Takes Two – Official Gameplay Trailer | PS5, PS4 | 521 | Preview |
| 61. | ACG | It Takes Two Review "Buy, Wait for Sale, Never Touch?" | 512 | Review |
| 62. | HaMa Kurdish | It Takes Two - حەمە و ئاکار دوو نەفەری یاری خۆش بەزم | 473 | |
| 63. | Altrive Plus | I want a divorce | 471 | |
| 64. | PlayStation | It Takes Two - The Game Awards 2020: Official Reveal Trailer | PS5, PS4 | 468 | |
| 65. | Rhymestyle | It Takes Two Idiots To Come Up With A Catchy YouTube Title So You See This Video In Your Feed 😂😂 | 460 | |
| 66. | OneyPlays | Getting Hammered in IT TAKES TWO - PART 2 | 451 | Let's Play |
| 67. | Rhymestyle | It Takes Two Idiots To Do Magic Tricks (WE JUMPED A PLUSHIE) | 441 | |
| 68. | Ethan Nestor | im getting a divorce | 438 | |
| 69. | Alienx Mongolia | ЯЛААНЫ ЗОВЛОН | It Takes Two EP-2 | w/@Ulaangamer | 430 | |
| 70. | SeeReax | It Takes Two Idiots To Fight A Squirrel | 428 | |
| 71. | Mithzan | It Takes Two | Chapter One | 427 | |
| 72. | Hollow | It Takes Two - Part 3 - IM ADDICTED TO THIS GAME | 424 | Walkthrough |
| 73. | PlayStation | It Takes Two – We’re Better Together Trailer | PS5, PS4 | 422 | Preview |
| 74. | Alienx Mongolia | ГЭЗЭГНИЙ ҮЗҮҮРЭЭР ХАТНЫГ... | It Takes Two EP-10 | w @Ulaangamer | 418 | |
| 75. | Alienx Mongolia | ТӨСӨӨЛШГҮЙ ТОГЛООМЫН ЕРТӨНЦ | It Takes Two EP-6 | w/@Ulaangamer | 416 | |
| 76. | JazzyGuns | CAN WE DO THIS??? | It Takes Two w/@DwayneKyng | Part 1 | 414 | |
| 77. | MoreMemeGod | FIGHTING A GIANT TOOLKIT MONSTER (It Takes Two) | 414 | |
| 78. | Rhymestyle | It Takes Two Idiots To Screw In A Light Bulb (WE'RE ACCIDENTAL GENIUSES) Episode 8 | 411 | Show |
| 79. | MoreMemeGod | ENTERING A GIANT BEEHIVE (It Takes Two) | 406 | |
| 80. | SeeReax | It Takes Two Idiots To Stop A Wasp Hive | 402 | |
| 81. | Rhymestyle | It Takes Two Idiots To Beat Plants vs Zombies | 398 | |
| 82. | Honest Game Trailers | Honest Game Trailers | It Takes Two | 390 | Preview |
| 83. | Hollow | It Takes Two - Part 4 - ITS ALL OVER 🙁 (ENDING) | 390 | Walkthrough |
| 84. | Rhymestyle | THIS GAME IS TOO TOXIC FOR US! It Takes Two Idiots Episode 6 | 388 | Show |
| 85. | Mithzan | It Takes Two | Chapter Six | 379 | |
| 86. | Rhymestyle | WE COULDNT STOP LAUGHING! It Takes Two Idiots Episode 2 | 377 | Show |
| 87. | Rhymestyle | IF YOU LAUGH, YOU KEEP WATCHING! It Takes Two Idiots Episode 4 | 372 | Show |
| 88. | GameGrumps | Don't forget to turn off the BALLS!!! | It Takes Two [9] | 367 | |
| 89. | Mr. Fruit | It Takes Two but I'm sober and he's not [PART 1/2] | 365 | Let's Play |
| 90. | GameGrumps | Death by rubber ducky!!! | It Takes Two [10] | 365 | |
| 91. | Dunk Tank | Dunk and Leah play It Takes Two | 361 | |
| 92. | OneyPlays | Really NAILING Tomar in IT TAKES TWO | 360 | Let's Play |
| 93. | MOGE Gaming | ЦАСАН БӨМБӨЛӨГ w/ @AlienxMongolia | It Takes Two Ep.09 | 359 | |
| 94. | Mithzan | It Takes Two | Chapter Three | 358 | |
| 95. | The Completionist | It Takes Two | The Completionist | 356 | Review |
| 96. | loltyler1 | TYLER1: IT TAKES TWO WITH MACAIYLA PART 2 | 353 | |
| 97. | Mithzan | It Takes Two | Chapter Seven - FINALE | 346 | |
| 98. | loltyler1 | TYLER1: IT TAKES TWO WITH MACAIYLA | 342 | |
| 99. | The Completionist | It Takes Two: Josef Fares Swears at Me in Arabic | 333 | Review |
| 100. | Nate the Hate | Nintendo Direct Predictions: GCN Joins NSO, Zelda: BotW2 Date, Metroid Prime & More (ft. Jeff Grubb) | 329 | |
