| 1. |  Cakes & Eclairs | SLANDER - I'm sorry don't leave me I want you here with me (Lyrics) | Love Is Gone | 84,264,585 | |
| 2. | JubyPhonic | Aishite Aishite Aishite (English Cover)【JubyPhonic】愛して愛して愛して | 21,181,054 | |
| 3. | Joueur Du Grenier | Papy Grenier - MASS EFFECT | 7,464,617 | |
| 4. |  Calvin Romeyn | Galactic Battles - A Crossover Fan Film Featuring: Star Wars, Star Trek, Halo & Mass Effect | 6,897,253 | |
| 5. | Mass Effect | The Next Mass Effect - Official Teaser Trailer | 6,098,581 | Preview |
| 6. |  miracleofsound | COMMANDER SHEPARD - The song (OFFICIAL VIDEO) by Miracle Of Sound | 4,742,709 | |
| 7. | Mass Effect | Mass Effect™ Legendary Edition Official Reveal Trailer (4K) | 4,703,678 | Vlog |
| 8. | TraciJHines | Sleeping Beauty - Traci Hines (OFFICIAL VIDEO) | 4,415,589 | |
| 9. | TVG | Расцвет и упадок Mass Effect | История серии (и компании BioWare). | 3,051,098 | |
| 10. |  eli_handle_b․wav | Austin Powers in Mass Effect: Part 1 | 2,855,222 | |
| 11. | AtinPiano | Mass Effect Trilogy Medley (Piano Cover) | 2,551,044 | Vlog |
| 12. | CorBreezy | RATE ME 1-10 KISS💋GRAB🍑OR SLAP👋 PUBLIC INTERVIEW SPRING BREAK EDITION! (GOT FREAKY⁉️) | 2,462,366 | |
| 13. | MSA previously My Story Animated | I Was Not Ready For What My Boyfriend Said About My Sister | 2,391,660 | |
| 14. | ProZD | Let Me Ask My Mom (Mass Effect) | 2,258,889 | |
| 15. |  GodOfCoffee | Don't Hug Me I'm Scared | Toda la Historia en 10 Minutos | 2,050,018 | |
| 16. |  AFGuidesHD | Battle of the Milky Way - Epic Space Battle - Mass Effect Legendary Edition Ending | 1,861,117 | |
| 17. | Mei Yu | Draw Disney Princesses as HOT GUYS | ART CHALLENGE! | Mei Yu Reimagine Challenge Genderbend | 1,835,814 | |
| 18. |  Eurogamerspain | Las 6 decisiones más difíciles en los videojuegos | 1,779,130 | |
| 19. | LostNUnbound | KEVIN DURANT CURSED AT ME!! NOT CLICKBAIT | 1,712,534 | |
| 20. | Comrade Bornath | Mass Effect - Main Theme | 1,698,343 | |
| 21. | eli_handle_b․wav | Michael Scott in Mass Effect | 1,660,291 | |
| 22. | Springbok ASMR | The Art of Mass Effect Book--Binaural ASMR With Book Sounds | 1,611,540 | |
| 23. | ICEnJAM | Commander Shepard Calls Gun Shops - Mass Effect Prank | 1,486,384 | |
| 24. | Mass Effect | Mass Effect Trilogy – Original Soundtrack | 1,485,591 | Vlog |
| 25. |  Commander Vakarian | Mass Effect Trilogy: Tali Romance Complete All Scenes | 1,432,783 | |
| 26. | Актерская Курилка | Самые неудачные русские озвучки видеоигр: Mass Effect & Dragon Age ⠂Подкаст Актерская Курилка | 1,410,022 | |
| 27. | eli_handle_b․wav | Michael Scott resolves conflicts in Mass Effect | 1,351,771 | |
| 28. | gameranx | Mass Effect Legendary Edition - Before You Buy | 1,340,076 | |
| 29. | BladeDJK | Mass Effect love | 1,317,851 | |
| 30. | IGN | Mass Effect Legendary Edition Changes - Original vs. Remastered Performance Preview | 1,309,817 | |
| 31. | TheShadowrunna | Mass Effect - #53 - Skandal! Sexszene! | 1,291,778 | |
| 32. | Hybrid | Mass Effect: Commander Shepard Is Such A Jerk | 1,267,548 | |
| 33. | GameExtender | Mass Effect Emotional Suite [Version 3] | 1,155,598 | |
| 34. |  AssopraFitas | MAIS 7 ESCOLHAS DIFÍCEIS DOS GAMES | 1,153,112 | |
| 35. | Hacksmith Industries | Testing a Real Mass Effect Plasma Rifle | 1,145,778 | |
| 36. |  itpedia | PS4 - НЕ ВЗЛОМАНА! /Подробно о прошивке PlayStation 4 | 1,101,594 | Let's Play |
| 37. | Ice Dog | Mass Effect - Sex Scene With Liara | 1,101,411 | |
| 38. | ProJared | Final Fantasy: The Spirits Within - ProJared | 1,082,014 | |
| 39. | The Escapist | MASS EFFECT (Zero Punctuation) | 1,077,099 | |
| 40. | Vsauce3 | Mass Effect DRESS and more!! -- Game LÜT #14 | 1,061,417 | |
| 41. | Ice Dog | Mass Effect - Conversation With Sovereign | 1,060,633 | |
| 42. | AFGuidesHD | All Space Battles in Mass Effect Legendary Edition | 1,054,610 | |
| 43. |  Gamer Cupu Official | UPIN MENIKAH DENGAN MEI MEI!! BELI MOBIL LAMBORGHINI - ROBLOX UPIN IPIN | 1,038,612 | |
| 44. | Naughty Gaming | Mass Effect Legendary Edition: Complete Ashley Romance | 1,033,094 | |
| 45. | Maxwell Gamer | Wait For Me I Got Little Legs 🦵🦵 | 991,428 | |
| 46. | Commander Vakarian | Mass Effect Trilogy: Garrus Romance Complete All Scenes | 980,807 | |
| 47. | P2istheName | I CHEATED On Miss Thotiana & SHE LEFT ME... OFFICIALLY SAD | 972,432 | |
| 48. | ZellenDust | DON'T HUG ME I'M SCARED 6 | ANALISIS EXPLICADO Y COMENTADO | 962,319 | |
| 49. | C_Squint | "You betrayed me..." [BNHA Comic Dub] | 915,360 | |
| 50. | Kevduit | Being a PSYCHOPATH in Mass Effect | 901,799 | |
| 51. | Smosh Games | BITTER RAGE ON LOVE (Top 5 Friday) | 882,809 | |
| 52. | ShoddyCast | The SCIENCE! Behind Mass Effect Technology | 864,567 | |
| 53. | ZellenDust | DON'T HUG ME I'M SCARED | ANALISIS EXPLICADO Y COMENTADO | 856,181 | |
| 54. | el prana | TEORI SERAM DON'T HUG ME I'M SCARED | 843,181 | |
| 55. | eezyTV | Berleezy Finds New Found Respect For Wrex In Mass Effect - Part 3 | 834,377 | |
| 56. | Felícia Rock | A COR DA MORTE (MISAKI MEI - ANOTHER) | FELÍCIA ROCK | 818,055 | |
| 57. | Naughty Gaming | Mass Effect Legendary Edition: Complete Tali Romance | 817,164 | |
| 58. | Funhaus | WHO NEEDS MASS EFFECT? - Push for Emor Gameplay | 816,789 | |
| 59. |  KingsOfFailsShow | PITAJ ME I JA TI ODGOVORIM #3- "Drama i pjesme xD" | 804,733 | |
| 60. | EckhartsLadder | Could the Halo Galaxy Survive a Reaper Invasion? Mass Effect vs Halo: Galactic Versus | 792,473 | |
| 61. | Pongsifu | Mass Effect Is a Meme | 779,908 | |
| 62. | Smosh Games | BEST VIDEO GAME HEROES (Why We're Single) | 775,471 | |
| 63. | Naughty Gaming | Mass Effect Legendary Edition: Complete Kaidan Romance (Fem Shep) | 774,544 | |
| 64. | pikmonwolf | Why Jacob Taylor Really is the Worst Squadmate in the Mass Effect Trilogy | 767,216 | |
| 65. | Nick930 | Mass Effect Legendary Edition vs Original Trilogy | Direct Comparison | 747,514 | |
| 66. | NeverKnowsBest | Mass Effect Trilogy - Review and Analysis | 744,628 | Review |
| 67. | TheAlmightyLoli | Mass Effect Series: A Beloved Franchise Treated Like a Battered Housewife | 741,992 | |
| 68. | GodOfCoffee | Don't Hug Me I'm Scared Temporada 2 | Toda la Historia en 10 Minutos | 735,498 | |
| 69. | Gaming Ambience | Mass Effect - Noveria: Port Hanshan Plaza (1 Hour of Music & Ambience) | 733,791 | |
| 70. | ArcadeCloud | Mass Effect COMPLETE Storyline in 3 minutes! (Mass Effect Animation) | 730,946 | |
| 71. | Mass Effect | N7 Day 2023 | 730,355 | |
| 72. | eezyTV | Berleezy Puts On For Humanity In Mass Effect - Part 2 | 728,028 | |
| 73. | GUZNO | БАЛДЕЖНОЕ ПРОХОЖДЕНИЕ Mass Effect Legendary Edition | 722,741 | |
| 74. | Smosh Games | VIDEO GAMES MAKE THE BEST TV SHOWS (Why We're Single) | 715,492 | Show |
| 75. | outsidexbox | 7 Redshirts Who Never Stood a Chance in Space | 710,615 | |
| 76. | Dorito's Reaction | DO NOT CALL RED PANDA MEI AND MING FROM TURNING RED!! (MEI VS MOM AT 4TOWN CONCERT) | 707,456 | |
| 77. | GameSpot | Mass Effect Legendary Edition Has HUGE Changes | 691,865 | |
| 78. | Smosh Games | GIVE THE OTHER GUY A CHANCE (Why We're SIngle) | 688,073 | |
| 79. | WaveMusic | Gryffin - Safe With Me (Lyrics) With Audrey Mika | 687,482 | |
| 80. | VenturianTale | Gmod MASS EFFECT Mod! | 685,714 | |
| 81. | Mass Effect | Mass Effect Trilogy Official Trailer | 673,384 | |
| 82. | Gaming Ambience | Mass Effect - Main Title Screen (1 Hour of Music) | 673,302 | |
| 83. |  KoroushGhazi | Mass Effect - PC Gameplay | 667,988 | |
| 84. | eezyTV | Berleezy Plays Mass Effect - Part 1 | 657,053 | |
| 85. | The 86th Floor: Cosplay and Cons | Bloopers and Outtakes 2018 (Miraculous Ladybug, Mass Effect, Life is Strange & more!) | 652,299 | |
| 86. | Gary | Top 100 PS3 Games according to Gamer Votes ... in 10 Minutes! | 651,001 | |
| 87. | ShoddyCast | The SCIENCE! Behind Reaper Indoctrination in Mass Effect | 649,110 | |
| 88. | Mass Effect | BioWare E3 Official Trailer - Mass Effect and New Title Update | 644,481 | Preview |
| 89. | Smosh Games | TOP 5 BANGABLE ALIENS | 643,872 | |
| 90. | ProZD | how mass effect missions are assigned | 642,528 | |
| 91. | Mass Effect | Mass Effect Legendary Edition – Official Remastered Comparison Trailer (4K) | 639,835 | Vlog |
| 92. | Naughty Gaming | Mass Effect Legendary Edition: Complete Miranda Romance | 639,241 | |
| 93. | Hollow | Mass Effect Legendary Edition - Part 1 - THIS GAME IS AMAZING | 627,538 | |
| 94. | JJDani | Mass Effect 1 & 2: Best of Renegade Lines and Funny Moments | 618,058 | |
| 95. | Gavinchi88 | Top 10 Mass Effect Trilogy Moments | 608,244 | Vlog |
| 96. | Сюжеты игр | Mass Effect Игрофильм | 598,941 | |
| 97. |  Fans Faction Studio | เปิดแฟ้มมอนสเตอร์ : มหากาพย์ Reaper ล้างจักรวาล เมื่อทางรอดเดียวของเราคือการทำลายล้าง | Mass Effect | 596,268 | |
| 98. | GameGasm | MASS EFFECT 5 Trailer (2023) 4K UHD | Unreal Engine 5 Game Trailers | 595,645 | Preview |
| 99. | SomeOrdinaryGamers | My Family Found Rule 34 Of Me... | 594,665 | |
| 100. | Edvard Wolf | Слёзы Олдфага - Mass Effect. Начало великой космооперы | 586,926 | |
