| 2025-04-08 |  Gaming Junk Shop | 8,700 | Pandemic II Flash Game Playthrough | 0:00 |
| 2023-10-14 |  Matteo_XZ | 629 | Pandemic II | Gameplay | 18:22 |
| 2023-08-02 | GamerWolfSix | 4,250 | Pandemic II | 44:36 |
| 2022-02-02 | GameFM | 16,800 | Debug Mode #432: Retrospectiva 2021 - Podcast | 4:22:16 |
| 2020-06-02 | brayzxo | 346 | CREATING COVID-19 IN PANDEMIC II! (Playing pandemic II! pt.2) | 4:51 |
| 2020-03-17 | Rasec Mouggier | 4,770 | Mouggier plays Pandemic II (Covid-19) | 15:18 |
| 2020-03-13 |  Sinstar | 451 | DEADLY VIRUS KILLS EVERYONE IN 4:20 - Pandemic 2 Any% Relaxed Mode Speedrun World Record | 4:26 |
| 2020-02-13 |  TerraChannel / TerraFox | 1,180 | Let's Play Pandemic II (German/Deutsch) | 11:44 |
| 2020-01-30 | The Diamond Invader | 895 | CORONAVIRUS GOES GLOBAL!! | PANDEMIC 2 | 22:22 |
| 2019-05-03 |  KC | 80,400 | 【対戦大量ゾンビ】新作Pandemic Expressを３人でプレイ！【あくまで個人戦】 | 53:51 |
| 2017-09-26 | 010COFFEE.channel | 495 | 【カゴシマニア】 1周年記念「パンデミック」大会#01【半生放送】第48回 | 20:01 |
| 2017-04-17 | Chatty Chatot | 615 | Pandemic II - (The Chatty Chatot Bacteria Spreads) | 19:47 |
| 2017-03-29 | Coach Keith Bridgeforth | 3,490 | Unboxing Pandemic By Z-man Games | 2:31 |
| 2017-03-10 | caramida9 | 20,100 | THE MEME ORIGINS! Let's play: Pandemic 2 | 18:10 |
| 2016-07-21 |  Manderby | 1,350 | Pandemic II Let's Play #3 German | 13:00 |
| 2016-02-19 | PolarizedMoon | 7,280 | MORE FAMILIAR TERRITORY -Pandemic II | Casual Friday | 15:58 |
| 2014-08-03 | Jon | 150,000 | Deadly Virus Infects The World! -- #PandemicII | 19:44 |
| 2014-02-25 | Starrlett | 2,400 | Starr Flashes Back! [Ep.1] Pandemic II | 23:23 |
| 2013-06-01 | Juca Metal (old channel) | 7,120 | Pandemic 2 | 7:21 |
| 2013-04-13 |  Shogunato Italiano | 4,790 | Flash Games #1 - Pandemic II Gameplay Ita | 11:48 |
| 2012-11-04 | MickyQuigleyTV | 440 | Pandemic II - WIN GAME! HUMANITY WIPED OUT | 1:52 |
| 2012-09-11 | StrongKPlays | 79 | Yay, It's Free! - Pandemic II [PC] | 34:05 |
| 2011-11-18 | KuuImpact | 1,670 | Let's Play Pandemic II 05 - Parasite You Later | 10:57 |
| 2010-07-02 | runekey | 1,730 | How I beat Pandemic II: MADAGASCAR = DEAD! | 10:00 |
| 2009-08-31 | BygPhattyPlus | 1,020 | Free Game Spotlight - Pandemic II | 10:50 |
| 2009-03-26 | Kyle Sullivan (TraskNari) | 14,000 | Let's Play Pandemic II! | 10:52 |
| 2009-02-05 | Jonathan Lewis | 197 | Let's Play Pandemic II part 3: OWNED!!!! | 7:06 |
