| 1. |  runekey | 102,155 | How I beat Pandemic II: MADAGASCAR = DEAD! | 10:00 |
| 2. | Kyle Sullivan (TraskNari) | 40,153 | Let's Play Pandemic II! | 10:52 |
| 3. | Jonathan Lewis | 11,640 | Let's Play Pandemic II part 3: OWNED!!!! | 7:06 |
| 4. | Jon | 7,176 | Deadly Virus Infects The World! -- #PandemicII | 19:44 |
| 5. |  KC | 5,569 | 【対戦大量ゾンビ】新作Pandemic Expressを３人でプレイ！【あくまで個人戦】 | 53:51 |
| 6. |  Juca Metal (old channel) | 2,580 | Pandemic 2 | 7:21 |
| 7. | GameFM | 2,361 | Debug Mode #432: Retrospectiva 2021 - Podcast | 4:22:16 |
| 8. |  Sinstar | 2,165 | DEADLY VIRUS KILLS EVERYONE IN 4:20 - Pandemic 2 Any% Relaxed Mode Speedrun World Record | 4:26 |
| 9. | KuuImpact | 1,958 | Let's Play Pandemic II 05 - Parasite You Later | 10:57 |
| 10. |  Shogunato Italiano | 1,222 | Flash Games #1 - Pandemic II Gameplay Ita | 11:48 |
| 11. | StrongKPlays | 859 | Yay, It's Free! - Pandemic II [PC] | 34:05 |
| 12. | Gaming Junk Shop | 566 | Pandemic II Flash Game Playthrough | 0:00 |
| 13. | Starrlett | 425 | Starr Flashes Back! [Ep.1] Pandemic II | 23:23 |
| 14. |  Manderby | 242 | Pandemic II Let's Play #3 German | 13:00 |
| 15. | Rasec Mouggier | 201 | Mouggier plays Pandemic II (Covid-19) | 15:18 |
| 16. | caramida9 | 201 | THE MEME ORIGINS! Let's play: Pandemic 2 | 18:10 |
| 17. | MickyQuigleyTV | 156 | Pandemic II - WIN GAME! HUMANITY WIPED OUT | 1:52 |
| 18. | The Diamond Invader | 108 | CORONAVIRUS GOES GLOBAL!! | PANDEMIC 2 | 22:22 |
| 19. | 010COFFEE.channel | 78 | 【カゴシマニア】 1周年記念「パンデミック」大会#01【半生放送】第48回 | 20:01 |
| 20. | BygPhattyPlus | 77 | Free Game Spotlight - Pandemic II | 10:50 |
| 21. | Coach Keith Bridgeforth | 69 | Unboxing Pandemic By Z-man Games | 2:31 |
| 22. | PolarizedMoon | 27 | MORE FAMILIAR TERRITORY -Pandemic II | Casual Friday | 15:58 |
| 23. | Chatty Chatot | 15 | Pandemic II - (The Chatty Chatot Bacteria Spreads) | 19:47 |
| 24. | GamerWolfSix | 15 | Pandemic II | 44:36 |
| 25. |  TerraChannel / TerraFox | 13 | Let's Play Pandemic II (German/Deutsch) | 11:44 |
| 26. | brayzxo | 8 | CREATING COVID-19 IN PANDEMIC II! (Playing pandemic II! pt.2) | 4:51 |
| 27. | Matteo_XZ | 0 | Pandemic II | Gameplay | 18:22 |
