| 1. |  Doctor Mike | Doctor Plays Plague Inc. | The Ultimate Bacteria! | Wednesday Checkup | 30,292 | Let's Play |
| 2. | SuperMega | SuperMega Plays PLAGUE INC. | 1,210 | Let's Play |
| 3. | IGN | IGN Plays Plague Inc - Zombie Virus Commentary | 873 | Let's Play |
| 4. | Pravus | Plague Inc: Official Scenarios - Santa's Little Helper (Mega Brutal) | 841 | Let's Play |
| 5. | lonniedos | PLAGUE INC. (iPhone Gameplay Video) | 496 | Let's Play |
| 6. | Pravus | Plague Inc: Official Scenarios - Smallpox (Mega Brutal) | 473 | Let's Play |
| 7. | lonniedos | PAPERS, PLEASE (iPad Gameplay Video) | 192 | Let's Play |
| 8. | lonniedos | BIG BUTT VIRUS?! - Plague Inc. (iPad Gameplay Video) | 128 | Let's Play |
| 9. | Pravus | Plague Inc: Custom Scenarios - Parasite Eve | 86 | Let's Play |
| 10. | lonniedos | TOILET PAPER SHORTAGE in PLAGUE INC. MOBILE! | 71 | Let's Play |
| 11. | Ethan Nestor | DANK MEMES | Plague Inc. Evolved #1 | 70 | Let's Play |
| 12. | Timeless Dubs | (Plague Inc. Versus) -Is it an Island? Maybe?- | 30 | Let's Play |
| 13. | Ethan Nestor | KILLING EVERYONE! | Plague Inc. #3 | 29 | Let's Play |
| 14. | Accurize2 | Survival Gaming Channel | Let's Play Plague Inc. | First Ebola, Now Vixen-B | #1 | 26 | Let's Play |
| 15. | ChunChasku | Chara Destroys the world with Determination Zombies! | Chara Plays Plague Inc! | 19 | Let's Play |
| 16. | NeosForme | So Many Stupid People! Plague Inc. Evolved | Neos Plays | 18 | Let's Play |
| 17. | Ethan Nestor | MEMETHAN | Plague Inc. #2 | 17 | Let's Play |
| 18. | PyroFalkon | PyroFalkon plays Plague Inc.: Evolved | 16 | Let's Play |
| 19. | Missildine Online! | ✔ One Part Plays | Plague Inc. Evolved! | 13 | Let's Play |
| 20. | blackm00n | PLAGUE INC//BLACKMOON VIRUSI TARQALISHI//UZBEKCHA LETSPLAY | 11 | Let's Play |
| 21. | Underrated54 | [Plague Inc. Evolved] First Playthrough! | 10 | Let's Play |
| 22. | Accurize2 | Survival Gaming Channel | Let's Play Plague Inc. | Going Viral | #2 | 6 | Let's Play |
| 23. | CamboCommando | Santa's Little Helper "Brutal" | PLAGUE INC. – Walkthrough Gameplay – Part 4 | 5 | Let's Play |
| 24. | Khimera Reine | TRYING TO SPREAD MY JOKER SYRUM: Joker Plays Plague Inc Mobile | 4 | Let's Play |
| 25. | JacksawJack | Let's Play Plague Inc. Evolved [Fungus] | 3 | Let's Play |
| 26. | _Egg | Just a Casual Playthrough of Plague Inc. | 3 | Let's Play |
| 27. | Rydo | Plague Inc. Evolved - Early Access #100 "Mega Simian Flu" (Mega Brutal) (1080p 60fps) | 3 | Let's Play |
| 28. | WheeliesTV | Nick plays Plague Inc.!!! (part 1) | 3 | Let's Play |
| 29. | JacksawJack | Let's Play Plague Inc. Evolved [Bacteria] | 3 | Let's Play |
| 30. | vlad the-tek (vladikx137) | HOW BAD CAN COVID-19 GET! | Plague Inc. Evolved #2 | 2 | Let's Play |
| 31. | PatchFNPainted | Lets Play Plague Inc! | 2 | Let's Play |
| 32. | PatchFNPainted | Lets Play Plague Inc! (Goverment) | 2 | Let's Play |
| 33. | PatchFNPainted | Let's Play Plague Inc! exterminate! | 2 | Let's Play |
| 34. | elizibar | No Apes II (Simian Flu/Casual) - Plague Inc: Evolved (Let's Play) Part 21 | 2 | Let's Play |
| 35. | PatchFNPainted | Lets Play Plague Inc! (Government 2) | 2 | Let's Play |
| 36. | KaffeineGaming | Santa's Helper - Plague Inc - Merry Christmas! | 2 | Let's Play |
| 37. | Rydo | Plague Inc. Evolved - Early Access #90 "Mega Virus" (Mega Brutal) (1080p 60fps) | 2 | Let's Play |
| 38. | PatchFNPainted | Lets Play Plague Inc! (more fun) | 2 | Let's Play |
| 39. | The Dreadheaded Oreo | Plague Inc. (first playthrough) [#1] | 1 | Let's Play |
| 40. | JacksawJack | Let's Play Plague Inc. Evolved [Necroa Virus] | 1 | Let's Play |
| 41. | elizibar | Bath Time Achievement - Plague Inc: Evolved (Let's Play) | 1 | Let's Play |
| 42. | BlackGaymerGod | Let's Play: Plague Inc. - Evolved | Quarantine for THE CURE! | 1 | Let's Play |
| 43. | JacksawJack | Let's Play Plague Inc. Evolved [Neurax Worm] | 1 | Let's Play |
| 44. | Solracdragon | Let's Play. Plague Inc. Evolved. Episode 2. Saturday Short. | 1 | Let's Play |
| 45. | elizibar | Contaminated Package Achievement - Plague Inc: Evolved (Let's Play) | 1 | Let's Play |
| 46. | vlad the-tek (vladikx137) | Mall Moms and Aliens! | Plague Inc. Evolved #1 | 1 | Let's Play |
| 47. | caramida9 | Coronavirus! Let's play: Plague Inc. Evolved Custom Scenario | 1 | Let's Play |
| 48. | Android Gamer TMG | Plague Inc. - HD Android Gameplay - Other games - Full HD Video (1080p) | 1 | Let's Play |
| 49. | Rydo | Plague Inc. Evolved - Early Access #74 "Pirate Plague" Scenario (Casual) (1080p 60fps) | 1 | Let's Play |
| 50. | PreX' Stylez | Let's Play Plague Inc. Evolved - Bacteria Casual #1 | 1 | Let's Play |
| 51. | Pickcha1 | Pickcha1 Play's | Plague Inc. Evolved | Bacteria Playthrough (Casual) | 1 | Let's Play |
| 52. | System Update | We Catch a Case of the Dahmers in Plague Inc. | 1 | Let's Play |
| 53. | elizibar | Fake News Scenario / Gamergate Achievement - Plague Inc: Evolved (Let's Play) | 1 | Let's Play |
