| 1. |  McRooster | 25,477 | PROTOTYPE 2 - Lab Rat Mission | 3:32 |
| 2. | Criminal 2020 | 21,184 | Prototype 2 - Pt 7 Ending | 1:58:40 |
| 3. | EB Games Australia | 16,245 | Prototype 2 Timeline - Trailer | 3:29 |
| 4. | I'mClownBTW | 14,234 | Evil Clowns Prototype 2 (Major Update) | 13:54 |
| 5. | AndrewPWH1 | 13,921 | Prototype 2 Blackwatch Collector's Edition Unboxing! | 5:54 |
| 6. | Homesteading with Hill | 7,187 | Prototype Testing the Water. | 3:16 |
| 7. | HacknSlashMB | 6,469 | Prototype 2 - All Bosses (With Cutscenes) [HD] | 56:17 |
| 8. | EPICTREASURE | 5,463 | Prototype 2: Green Zone Mutagen Collection Tutorial (Commentary) | 3:00 |
| 9. | KjraGaming | 4,898 | SPAWN VS LOBO - BLOODY FIGHT - GRAND THEFT AUTO | 3:50 |
| 10. | ABC Gamer | 4,723 | Good Game Review - Prototype 2 - TX: 08/05/12 | 9:11 |
| 11. | Media Maniac | 2,725 | Prototype & Prototype 2 Xbox 360 #shorts #xbox360 | 0:11 |
| 12. | Spoony Gamez | 2,570 | PROTOTYPE 2 Makes You Feel Like A GOD #shorts | 0:55 |
| 13. | Nebo | 1,221 | Prototype 2 : AMD R7 370 (1080P/Maxed) | 2:32 |
| 14. | Kitty’s Minecraft Builds | 1,098 | [PROTOTYPE®2] - Red Zone's Height limit (Gunship heli - 220ft) | 0:00 |
| 15. | LeerySquid13 | 850 | Prototype 2 - Part 5 | 4:26:04 |
| 16. | DAMIENthGMV | 668 | [GMV] Prototype | Morphos | 2:09 |
| 17. | MrLionKing | 437 | Prototype 2 PS5 - Whipfist | 0:00 |
| 18. | NovaGhost | 370 | Prototype 2 Lets Play #10 | Hard Difficulty | 12:15 |
| 19. | J4CKM4N2266 | 287 | Prototype 2 pt34 (FINAL) | 13:04 |
| 20. | Luke Wilson gaming | 285 | prototype 2 killing the juggernaut | 17:09 |
| 21. | ZagsTheMan | 280 | PROTOTYPE 2 - 5 Minutes of Free Roam Gameplay (PC) | 5:00 |
| 22. | EnigmaStJimmy | 230 | Prototype 2 PS4 Playthrough Pt 12 Mercer (The Ending) | 33:12 |
| 23. | Storm Wolf Gaming | 227 | Prototype 2 missions and other brutal moments #3 | 1:10:42 |
| 24. | Platinum Hunters | 189 | Platinums With Playbox #145 Prototype 2 PS4 | 9:38 |
| 25. | GrizGaming | 151 | Prototype 2 (PS4) - First 15 mins | 15:00 |
| 26. | MR Todd West | 98 | Prototype 2 part 3 Alex Mercer's Master plan | 33:05 |
| 27. | ThePostalGamer | 93 | [PROTOTYPE2] - (Part 08, Final) - Omega | 2:02:29 |
| 28. | TheNeonDiablo | 77 | Prototype Hard Difficulty For Platinum Trophy Part 2 | 42:02 |
| 29. | LIQUID STUDIOS - GAMER | 63 | HELLER Takes On SPEC OPS In EPIC Showdown! | 0:00 |
| 30. | ElvishQuasar | 62 | Prototype 2 Gameplay Part 12 - The Descent | 22:40 |
| 31. | Gamer Jess | 55 | Saving my daughter & destroying my maker, all in a day's work - Prototype 2 Ep 10 | 40:50 |
| 32. | Dr. Amethyst | 53 | Prototype 2 Stream - Praying that the autosave kicked in | 3:54:48 |
| 33. | Payday Productions HD | 35 | P² Plays : JP plays Prototype 2 | Heller Vs Mercer | 6:15 |
| 34. | Creeper nation gaming | 34 | World eater prototype 2 for bedrock edition | 3:08 |
| 35. | Canguro Gaming | 31 | Prototype 2 (Hard Playthrough) PS5 | 11:09:55 |
| 36. | The Lovable Protagonist | 27 | [EPISODE 3] - [PROTOTYPE2] (Brain Drain) | 9:41 |
| 37. | RydeOrDie | 25 | 5 last-gen games that NEED to be remastered......RydeorDie | 6:54 |
| 38. | CynicalSlaya | 19 | Prototype 2 Insane Difficultly Is Too Easy | 3:06 |
| 39. | Hack The Dino Gamingcast - A Video Game Podcast | 17 | PROTOTYPE 2 | Prototype 2 | PART 1 | 2:34:50 |
| 40. | EvanBaracuda | 16 | [PROTOTYPE2]_2023/04/28/20:12:40 Over equipped trophy | 0:30 |
| 41. | ProForLife9 | 12 | [PROTOTYPE] Part 5 | 0:00 |
| 42. | Glitched_Guy | 10 | Prototype 2 Stream [16/08/2020] | 2:04:59 |
| 43. | YTHabagat Pinoy Gaming | 10 | (PS4) PROTOTYPE 2-KILLING TIME | 1:20:34 |
| 44. | JBZification is a salty cabbage | 9 | And yes more prototype | 1:26 |
| 45. | IllukaMonti | 6 | Badass Prototpe 2 Scene...... | 1:21 |
| 46. | Searching For Other Players | 4 | Prototype 2 (2012) - Opening Video | 6:56 |
| 47. | Ballfartmonkey | 2 | Starting The Prototype 1 & 2 Platinum Trophies | 10:34 |
| 48. | Blacksnow Fanfics and Gaming | 2 | Prototype 1: Episode 1 Part 2 | 8:04 |
