| 1. |  WatsonKHD | PROTOTYPE 2's Platinum Trophy was HELL-ER Fun | 74 | Let's Play |
| 2. | Gamesweasel | Play Prototype 2 online | 58 | Let's Play |
| 3. | Dat Mental Gamer | [PROTOTYPE 2] | Alpha Alex Mercer Mod - Free Roam Combat | 48 | Let's Play |
| 4. | Elanip | Let's Play Prototype 2 - Walkthrough - Final Boss Defeat Alex Mercer (Ending Cutscene - End of Game) | 18 | Let's Play |
| 5. | IFreeMz | Prototype 2 Gameplay Walkthrough Part 19 - Alpha Wolf - Let's Play Review | 12 | Let's Play |
| 6. | Dat Mental Gamer | [PROTOTYPE 2] | Alpha Alex Mercer (First Variant) | 10 | Let's Play |
| 7. | Elanip | Let's Play Prototype 2 - Walkthrough - See HUGE Infected Monster and Get Infected by Alex Mercer | 10 | Let's Play |
| 8. | Dat Mental Gamer | [PROTOTYPE 2] | New Armor and Alpha/Beta Boss Alex (Model Swap Mods) | 9 | Let's Play |
| 9. | PlayStation Access | PlayStation Access TV 30 - Prototype 2! Max Payne 3! Gadgets! | 9 | Let's Play |
| 10. | Guides For Gamers | Prototype 2 - Let's Play #1: 0 - 25% Completion | 9 | Let's Play |
| 11. | Elanip | Let's Play Prototype 2 - Walkthrough - Blackwatch Missions (A.K.A Side Missions) | 6 | Let's Play |
| 12. | Elanip | Let's Play Prototype 2 - Walkthrough - Learning The Ropes of Consuming People | 6 | Let's Play |
| 13. | Elanip | Let's Play Prototype 2 - Walkthrough - Unlocked a New Attack Awesome Black Hole | 6 | Let's Play |
| 14. | Elanip | Let's Play Prototype 2 - Walkthrough - Escape Blackwatch Testing and We're Working with Alex Mercer? | 6 | Let's Play |
| 15. | samdaman118 | Prototype 2 Lets Play Commentary Part 1 | 4 | Let's Play |
| 16. | Elanip | Let's Play Prototype 2 - Walkthrough - Lair Domination | 4 | Let's Play |
| 17. | Dat Mental Gamer | [PROTOTYPE 2] | Alpha Alex Mercer (Second Variant) | 4 | Let's Play |
| 18. | The Real OAF | Let's Play - Prototype 2 (Part 2) [PC] | 4 | Let's Play |
| 19. | samdaman118 | Prototype 2 Lets Play Commentary Part 2 | 4 | Let's Play |
| 20. | ScottishFeller | Prototype 2 | Playthrough #21 | Fall From Grace | 4 | Let's Play |
| 21. | Alpaka Whacker | Alpaka Plays "Prototype 2" - Episode 10 : Violently Ripping Orion Apart | 4 | Let's Play |
| 22. | samdaman118 | Prototype 2 Lets Play Commentary Part 13 | 3 | Let's Play |
| 23. | TRW | Prototype 2 Playthrough | Part 27 | 3 | Let's Play |
| 24. | TRW | Prototype 2 Playthrough | Part 5 | 3 | Let's Play |
| 25. | The Real OAF | Let's Play - Prototype 2 (Part 1) [PC] | 3 | Let's Play |
| 26. | Alpaka Whacker | Alpaka Plays "Prototype 2" - Episode 2 : Consume, Throw, Destroy | 3 | Let's Play |
| 27. | Elanip | Let's Play Prototype 2 - Walkthrough - VERY BIG GAME TWIST | 3 | Let's Play |
| 28. | TRW | Prototype 2 Playthrough | Part 1 | 3 | Let's Play |
| 29. | Alpaka Whacker | Alpaka Plays "Prototype 2" - Episode 1 : Becoming A Monster | 3 | Let's Play |
| 30. | Elanip | Let's Play Prototype 2 - Walkthrough - GET TO THE CCHHHHHOOOOOPPPPPAAAAA | 2 | Let's Play |
| 31. | TRW | Prototype 2 Playthrough | Part 21 | 2 | Let's Play |
| 32. | Alpaka Whacker | Alpaka Plays "Prototype 2" - Episode 3 : Brawler Battle Bonanza | 2 | Let's Play |
| 33. | Elanip | Let's Play Prototype 2 - Walkthrough - Backstabbed by The Doctor | 2 | Let's Play |
| 34. | samdaman118 | Prototype 2 Lets Play Commentary Part 18 | 2 | Let's Play |
| 35. | TRW | Prototype 2 Playthrough | Part 25 | 2 | Let's Play |
| 36. | Elanip | Let's Play Prototype 2 - Walkthrough - Blackwatch Missions are Finished! Finally | 2 | Let's Play |
| 37. | TRW | Prototype 2 Playthrough | Part 11 | 2 | Let's Play |
| 38. | Elanip | Let's Play Prototype 2 - Walkthrough - ROOKS Helped Me Find My Daughter?!?!? | 2 | Let's Play |
| 39. | TRW | Prototype 2 Playthrough | Part 48 | 2 | Let's Play |
| 40. | TRW | Prototype 2 Playthrough | Part 3 | 2 | Let's Play |
| 41. | TRW | Prototype 2 Playthrough | Part 34 | 1 | Let's Play |
| 42. | TRW | Prototype 2 Playthrough | Part 4 | 1 | Let's Play |
| 43. | TRW | Prototype 2 Playthrough | Part 38 | 1 | Let's Play |
| 44. | samdaman118 | Prototype 2 Lets Play Commentary Part 3 | 1 | Let's Play |
| 45. | samdaman118 | Prototype 2 Lets Play Commentary Part 15 | 1 | Let's Play |
| 46. | TRW | Prototype 2 Playthrough | Part 23 | 1 | Let's Play |
| 47. | The Real OAF | Let's Play - Prototype 2 (Part 6) [PC] | 1 | Let's Play |
| 48. | The Real OAF | Let's Play - Prototype 2 (Part 5) [PC] | 1 | Let's Play |
| 49. | The Real OAF | Let's Play - Prototype 2 (Part 8 + Final) [PC] | 1 | Let's Play |
| 50. | TRW | Prototype 2 Playthrough | Part 2 | 1 | Let's Play |
| 51. | The Real OAF | Let's Play - Prototype 2 (Part 7) [PC] | 1 | Let's Play |
| 52. | ExcaliburTF93 | Prototype 2 Playthrough Part 18 | 1 | Let's Play |
| 53. | The Real OAF | Let's Play - Prototype 2 (Part 4) [PC] | 1 | Let's Play |
| 54. | TRW | Prototype 2 Playthrough | Part 29 | 1 | Let's Play |
| 55. | samdaman118 | Prototype 2 Lets Play Commentary Part 10 | 1 | Let's Play |
| 56. | samdaman118 | Prototype 2 Lets Play Commentary Part 17 | 1 | Let's Play |
| 57. | Alpaka Whacker | Alpaka Plays "Prototype 2" - Episode 4 : Training Your Heller to Evolve with Rare Candy | 1 | Let's Play |
| 58. | Elanip | Let's Play Prototype 2 - Walkthrough - Side Mission Consuming Like a Ninja | 1 | Let's Play |
| 59. | TRW | Prototype 2 Playthrough | Part 13 | 1 | Let's Play |
| 60. | TRW | Prototype 2 Playthrough | Part 20 | 1 | Let's Play |
| 61. | TRW | Prototype 2 Playthrough | Part 55 [FINAL] | 1 | Let's Play |
| 62. | The Real OAF | Let's Play - Prototype 2 (Part 3) [PC] | 1 | Let's Play |
| 63. | TRW | Prototype 2 Playthrough | Part 39 | 1 | Let's Play |
| 64. | TRW | Prototype 2 Playthrough | Part 47 | 1 | Let's Play |
| 65. | TRW | Prototype 2 Playthrough | Part 7 | 1 | Let's Play |
| 66. | TRW | Prototype 2 Playthrough | Part 15 | 1 | Let's Play |
| 67. | samdaman118 | Prototype 2 Lets Play Commentary Part 4 | 1 | Let's Play |
| 68. | samdaman118 | Prototype 2 Lets Play Commentary Part 6 | 1 | Let's Play |
| 69. | TRW | Prototype 2 Playthrough | Part 6 | 1 | Let's Play |
| 70. | TRW | Prototype 2 Playthrough | Part 19 | 1 | Let's Play |
| 71. | TRW | Prototype 2 Playthrough | Part 9 | 1 | Let's Play |
| 72. | TRW | Prototype 2 Playthrough | Part 17 | 1 | Let's Play |
| 73. | TRW | Prototype 2 Playthrough | Part 18 | 1 | Let's Play |
| 74. | TRW | Prototype 2 Playthrough | Part 53 | 1 | Let's Play |
