| 1. |  Airton | PROTOTYPE - PS5™ Gameplay [4K HDR] | 3,761,725 | |
| 2. |  Ken Block | Ken Block’s NEW Audi #S1HOONITRON Gymkhana Prototype! | 3,596,213 | |
| 3. |  CaptHotah | Prototype - Opening cinematic trailer [HD] | 3,144,959 | Preview |
| 4. | CRHateR | Игры на вынос - Prototype | 2,499,064 | |
| 5. | MetalJesusRocks | FOUND: Ultra-Rare Nintendo Prototype N64 Add-On (US Version of 64DD) | 2,455,884 | |
| 6. |  StopGame - All about video games! | Разбор полётов. Prototype | 2,034,302 | |
| 7. | Gamer's Little Playground | PROTOTYPE All Cutscenes (Game Movie) 1080p HD | 2,019,853 | |
| 8. | Splice | Про что был Prototype | 1,875,457 | |
| 9. | CoryxKenshin | Super Hot (+Download) | September 2013 Prototype | 1,860,989 | |
| 10. | Первый Хоррор Канал | Prototype Прохождение На Русском #1 — СМЕРТЬ ГОРОДА! ПРОТОТИП! | 1,686,983 | |
| 11. | TVG | Расцвет и упадок Prototype | История серии. | 1,593,501 | |
| 12. |  Nico Rosberg | World’s First Drive of The New Rimac Nevera Prototype!! | Nico Rosberg | 1,487,920 | |
| 13. | Prototype | [PROTOTYPE] - Opening Cinematic Trailer | 1,450,409 | Preview |
| 14. |  Majorkill | The Emperor's Failed Primarch Prototype : The Angel of Destruction #warhammer40k | 1,364,125 | |
| 15. | People Make Games | The Game Prototype That Had to Be Banned by Its Own Studio | 1,351,955 | |
| 16. | GoldenDiamond | Poppy Playtime -1006 The Prototype VHS (Concept) | 1,349,993 | |
| 17. | Whitelight | Designing PROTOTYPE 3 - Gameplay | 1,317,060 | |
| 18. | Unseen Halo - Corbin | PROTOTYPE - Gameplay HD | 1,236,796 | |
| 19. | Whitelight | PROTOTYPE: 10 Years Later | 1,226,391 | Review |
| 20. | MetalJesusRocks | Prototype USA 64DD UPDATE - The Adventure Continues!! | 1,090,326 | Vlog |
| 21. | AngryJoeShow | Prototype Review by Alex Mercer | 1,039,715 | Review |
| 22. | FireoftheNight | Alex Theme - [PROTOTYPE] Soundtrack | 1,001,992 | |
| 23. | SkyTheSpy | Epic Prototype Moments: #1 (The Rise of Alex Mercer) | 976,991 | |
| 24. | MKIceAndFire | PROTOTYPE PS5 Gameplay Walkthrough Part 1 FULL GAME [4K ULTRA HD] - No Commentary | 975,312 | Walkthrough |
| 25. | ZAK | Литерал - PROTOTYPE | 941,879 | |
| 26. | GmanLives | The Prototype Games Are Still Absolutely Insane | 916,995 | |
| 27. | IGM | КАК ПОГИБЛА PROTOTYPE | 888,859 | |
| 28. | skorch82 | Prototype - Part 1: Intro | 866,706 | Let's Play |
| 29. |  Windah Basudara | GAME INI KELIATAN SANGAT REALISTIS TAPI.... Deppart Prototype | 856,758 | |
| 30. | Pixels | Hot Wheels Race Off - New Car HW Drift Prototype / New Level | 782,506 | |
| 31. | Purposeless Rabbitholes | Let's Make a Game: PROTOTYPE 3 | 764,030 | |
| 32. |  Burak Oyunda | EFSANE OYUN! - PROTOTYPE | 763,419 | |
| 33. |  Kevduit | So I FINALLY Tried PROTOTYPE | 753,304 | |
| 34. | VIP2GAMING | Prototype Gameplay | 703,077 | |
| 35. | isight | I INSTANTLY Hatched 1st HUGE M-10 PROTOTYPE... | 680,438 | |
| 36. | Wow Such Gaming | Why You Wouldn't Survive Prototype's Blacklight Virus | 671,323 | |
| 37. | KittenSneeze | Peridot | Prototype VIP | PMV | 645,697 | |
| 38. | Kevduit | Prototype 2 is a PSYCHOPATH playground | 637,745 | |
| 39. |  Kratosworld | Prototype - Pelicula completa en Español - PC Ultra [1080p 60fps] | 627,005 | |
| 40. | Первый Хоррор Канал | Prototype Прохождение На Русском #14 — ФИНАЛ / Ending | 624,021 | |
| 41. |  TotalWeGames | PROTOTYPE 3 - ТРИ ГЛАВНЫХ ГЕРОЯ / НОВАЯ ИНФОРМАЦИЯ! | 609,535 | |
| 42. | Gamers Nexus | NVIDIA's Unreleased TITAN/Ti Prototype Cooler & PCB | Thermals, Acoustics, Tear-Down | 607,711 | |
| 43. | The Black Mastadonte | [Prototype] The Full Story of Prototype 💥 | 599,595 | |
| 44. | Amway921 | T28 Prototype - Ну наконец-то | 589,145 | |
| 45. | Enis Kirazoglu | TÜRKİYE'DE ANORMAL DERECEDE SEVİLEN OYUN: PROTOTYPE | 578,092 | |
| 46. | Button Mash | What the Hell Happened to Prototype? | 562,330 | |
| 47. | FireoftheNight | Memory In Death - [PROTOTYPE] Soundtrack | 553,502 | |
| 48. | TotalWeGames | PROTOTYPE 3 - НАКОНЕЦ-ТО НОВАЯ ИНФОРМАЦИЯ / СПУСТЯ 5 ЛЕТ! | 551,021 | |
| 49. |  Phân Tích Game | Tóm tắt cốt truyện: PROTOTYPE Story | PTG | 550,347 | |
| 50. | RusGameTactics | Прохождение Prototype - Миссия 1 — Побег из ГЕНТЕК | 530,040 | |
| 51. |  온다람 | 바이러스로 인해 먹이 사슬의 최정점이 된 끔찍한 남자 | 508,469 | |
| 52. | GUZNO | БАЛДЕЖНОЕ ПРОХОЖДЕНИЕ Prototype | 502,552 | |
| 53. | Black Ninja | Пасхалки в игре Prototype [Easter Eggs] | 500,635 | |
| 54. | SonnyK | Prototype в 2022 году... | 498,792 | |
| 55. | PlayStation | Project Morpheus: Hands on with PS4's Prototype Virtual Reality System | 495,327 | Let's Play |
| 56. |  Luis Dewitt | ¿Qué es el Virus Blacklight? EXPLICACIÓN | El Virus Blacklight o Virus Mercer de Prototype EXPLICADO | 494,354 | |
| 57. | TotalWeGames | PROTOTYPE 3 - ПОКАЗАЛИ ГЛАВНОГО ГЕРОЯ? КТО ЭТОТ ПАРЕНЬ? / ВСЯ ПРАВДА О КАРТИНКЕ! [Очередной фейк] | 463,950 | |
| 58. | Full Playthroughs | Prototype | Gameplay Walkthrough - FULL GAME | HD | No Commentary | 462,596 | Walkthrough |
| 59. |  EndlessChannel TH | สรุปเนื้อเรื่องเกม Prototype ภาค 1 ใน 6 นาที !!! | 459,544 | |
| 60. | TotalWeGames | Скачал PROTOTYPE 3 - ПЕРВЫЙ ЗАПУСК ФАЙЛА! [ЧТО Я СКАЧАЛ НА ТОРРЕНТЕ?] | 453,034 | |
| 61. | Чувак | Что такое Prototype? | 452,774 | |
| 62. | SethBling | Minecraft 12w32a: Push Map with Classes using Command Blocks (Prototype) | 451,746 | |
| 63. |  Series X | Prototype 1 Complete Story In Hindi | Origin story of Alex Mercer Explained In Hindi | 450,136 | |
| 64. | Dimia clay | Making All HUGGY WUGGY Compilation with clay, sculpture timelapse (FNF mods, Minecraft, Prototype) | 439,985 | Let's Play |
| 65. | 1980sGamer | Rare Nintendo TS (Triple Screen Prototype!) | 436,294 | |
| 66. | Classic Game Room | Classic Game Room HD - PROTOTYPE review | 418,551 | Review |
| 67. | Morninglord22 | Prototype Speed Parkour (PS3) | 413,363 | |
| 68. | Rooster Teeth | Pajamachievements: Prototype | Rooster Teeth | 406,908 | Show |
| 69. | TetraNinja | Prototype Walkthrough - Part 4 Elizabeth Greene Let's Play PS3 XBOX PC (Gameplay / Commentary) | 402,317 | Walkthrough |
| 70. | Ericck Arts | Drawing The Prototype, Barry, Mini Huggy, and Rejected Toys In POPPY PLAY TIME | 397,440 | |
| 71. | Luis Dewitt | ¿Qué son las Criaturas de Prototype? EXPLICACIÓN | Los Monstruos del Virus Blacklight EXPLICADOS | 386,383 | |
| 72. | Vandal | 5 DETALLES ALUCINANTES DE PROTOTYPE #prototype | 380,507 | |
| 73. | GarlandTheGreat | Crash Bandicoot Prototype Version - Complete Playthrough & Unused Levels | 376,692 | Let's Play |
| 74. | HandOfUncut | WIE GEIL IST DIESES GAME?! Noita + Brotato = Bio Prototype | 375,257 | |
| 75. | TotalWeGames | Spider-Man - Найден возможный дом АЛЕКСА МЕРСЕРА? Алекс Мерсер в Человеке-пауке? (Квартира Мерсера) | 363,692 | |
| 76. | KaliTerran | Prototype 1 | Parte 1 | Español | 361,952 | |
| 77. | FireoftheNight | A Dream Of Armageddon - [PROTOTYPE] Soundtrack | 359,544 | |
| 78. | MR. ILLUSTRATED | SCP-001 - The Prototype | 359,115 | |
| 79. | Rios Visuals | [Prototype] Music Video- Sound of Madness | 358,882 | |
| 80. | Burak Oyunda | GÜZEL KIZIN LANETİ - PROTOTYPE - BÖLÜM 2 | 355,042 | |
| 81. | Первый Хоррор Канал | Prototype Прохождение На Русском #2 — СОТНИ ТРУПОВ! МАТЬ ПРОТОТИПА?! | 345,915 | |
| 82. | Game Reactions | Gamers React to a Figure Running Across The Hallway (JUMPSCARE) | Deppart (Prototype) | 342,241 | |
| 83. | SpecterChannel | Можно ли пройти Prototype без прокачки навыков? | 333,332 | |
| 84. | Bon Gamerz | BGZ - Prototype #1 ฮีโร่มนุษย์กลายพันธุ์ | 324,876 | |
| 85. | L Plays | Is This The Most Surreal & Ambitious Open World Survival Game Prototype...Ever? [Towers Game] | 324,216 | |
| 86. | clip extra | CORINGA JOGANDO Deppart Prototype | 311,877 | |
| 87. | TetraNinja | Prototype Walkthrough - Part 5 Claw Powers Let's Play PS3 XBOX PC (Gameplay / Commentary) | 309,368 | Walkthrough |
| 88. | xXSlyFoxHoundXx | Homies Power Level Friday: 700th Video [Prototype] Ep.1 | 309,063 | |
| 89. | 푸린 | 추억의 PC방 게임 프로토타입 세계 1등은 어떤 사람일까? | 305,902 | |
| 90. | Arekkz Gaming | Microsoft Cloud Gaming Prototype (Build 2014 Xbox One/PC) | 304,647 | |
| 91. | GVMERS | The Radical History of Prototype | 298,190 | |
| 92. | redhotsonic | Sonic X-Treme prototypes and more - But does it work on Real Hardware? | 291,645 | |
| 93. | Taki Udon | The Steam Deck Ultra is Here! - HUGE Screen & Battery // AYANEO Kun First Look | 288,481 | |
| 94. | Mundus | What everyone thinks about Arthur Pendragon (Prototype) | 288,342 | |
| 95. | skorch82 | Let's Play: [Prototype] [PS3][HD] - Part 2: I Will Eat Your Soul | 287,243 | Let's Play |
| 96. |  兄者弟者 | 【ボディカム風ホラー】弟者の「Deppart Prototype」【2BRO.】 | 284,855 | |
| 97. | Moby | Prototype Walkthrough - Part 1 - Escape From the Gentek Facility Let's Play XBOX PS3 PC | 282,382 | Walkthrough |
| 98. | Alpha Beta Gamer | Black Resin: Become an Amorphous Inky Monster this Cinematic Reverse Horror Action Game (Prototype) | 281,418 | |
| 99. | Purposeless Rabbitholes | Why the World Needs a New [PROTOTYPE] Game | 280,109 | Discussion |
| 100. |  Хумас | НЕПРОСТОЙ ТИП [Prototype] | 272,626 | |
