| 1. | NoodsNoodle | 7,206,061 | Dragula - 100% FC expert Rock Band 2 (drums) | 4:02 |
| 2. | azuritereaction | 6,042,882 | "Science Genius Girl" by Freezepop (Rock Band 2 Expert Drums + Vocals 100% FC) | 3:45 |
| 3. | Sascha Van Stichel | 1,425,019 | GH 5: "Scream" by Avenged Sevenfold (expert+ drums sightread 5*) | 5:08 |
| 4. | UKOGmonkey | 962,693 | :O When you hit something and don't know how... | 5:41 |
| 5. | KKoserYaks | 935,536 | Rock Band 2 Stream (Channel Anniversary 2021 Part 4) | 59:11 |
| 6. | Electronic Arts | 571,794 | Rock Band 2 -- First Trailer | 1:17 |
| 7. | dbert1024 | 155,303 | Waking the Demon 5GS (Rock Band 2 Expert Drums) | 4:41 |
| 8. | gamerscoreblog | 121,852 | CES 2008: Ion Rock Band 2 Drum Prototype Drumset | 3:00 |
| 9. |  Chill2Music | 118,560 | De-Luxe - Lush (Performance Mode) (Rock Band 2 Deluxe) | 3:37 |
| 10. | qwertymodo | 106,104 | Rock Band Custom: Disciple - The Ballad of St. Augustine (Drums, Expert) [FoFiX] | 4:25 |
| 11. | ApFaqTech | 95,942 | Rock Band 2 Unboxing | 2:00 |
| 12. | HeikkiX360 | 92,903 | Rock Band 2 - 'Lookin' for a Good Time' by Lady Antebellum (drums expert) | 3:21 |
| 13. | StarSlay3r | 84,183 | Rock Band 2 - Ramblin Man Expert Guitar 100% Full Combo | 6:35 |
| 14. | PuppetMaster9 | 82,068 | Rock Band 2 Expert Guitar Full Game FC! - "Bodhisattva" 100% FC | 5:55 |
| 15. | TechAppsNGames | 79,509 | Rockband 2 - Opening Cinematic (HD) 1080P | 2:02 |
| 16. | GameSpot | 78,841 | Rock Band 2 DLC Video Preview: Queen and Abbey Road | 2:24 |
| 17. | lifeandlevel | 78,235 | EP07 Rockband 2 - Pepper Spray | 8:47 |
| 18. | SourceFedNERD | 73,260 | Rock Band RETURNS?!! | 2:23 |
| 19. | SoundDefenseRB | 69,459 | Rock Band 2 (Custom Song) - Arctic Monkeys "Brianstorm" | 3:14 |
| 20. | Niklas Börjesson | 69,322 | RB2 Drums My Generation (Live at Leeds) 100% FC | 4:19 |
| 21. | Inside Gaming | 64,187 | New Rock Band Game in the Works - The Know | 2:23 |
| 22. | gamingbits | 61,389 | Official Rock Band Trailer (PS3/Xbox 360/wii) | 1:11 |
| 23. |  The Stuttering Gamer | 60,401 | Rock Band 2 Wii Music Store - How To Buy Downloadable Content Overview | 7:13 |
| 24. |  GXZ95 | 57,934 | Rock Band Metal Track Pack (PS2 Gameplay) | 14:47 |
| 25. | JForJack | 54,518 | I Attempted Rock Band's Most Infamous Achievement | 8:02 |
| 26. | DeNice1776 | 54,270 | Rock Band 2: Arcaedion 99% Gold Stars - Expert Guitar - Sightread (RBN song) | 5:09 |
| 27. | DJX | 53,824 | Michelle - The Beatles Guitar FC (TBRB-to-RB2) HD Gameplay (Xbox 360) | 3:05 |
| 28. | PinkPixy | 43,932 | Ocean Avenue - Rock Band Expert Vocals Quartet | 3:30 |
| 29. | Joey Crick | 43,659 | Rock Band 2 Deluxe - This Ain't a Scene, It's an Arms Race (Hard Guitar 100% FC, 126,392 🌟🌟🌟🌟🌟) | 3:58 |
| 30. |  RPCS3 | 43,620 | RPCS3 - Rock Band 1 & 2 now Playable with Instrument Support! | 13:13 |
| 31. | Gravenhex | 40,724 | How to | Play ALL Guitar Hero's on PC | FAST + SIMPLE | 10:49 |
| 32. | NickOfTime | 37,584 | Rock Band 2: Waking the Demon (Expert Gtr) GS 100% FC | 4:27 |
| 33. | SynysterKobra | 34,598 | RB2 - Reinventing Your Exit - Expert Guitar 100% FC 5GS | 4:41 |
| 34. | 2MAD4GAMING | 33,230 | Rock Band 2: The Endless Setlist: Bonus Video: Highlights & Instrument Swap | 34:31 |
| 35. | WIRED | 33,048 | Game|Life 29: Rock Band 2, Wipeout HD | 6:40 |
| 36. | szymmirr | 32,576 | Rock Band 2 - Soundtrack | 5:13:39 |
| 37. | Storm Dain Productions | 30,528 | Storm's Adventure with Rock Band 2 Et Al | 10:17 |
| 38. | Alexis Rivera | 30,260 | Rock Band - Rush - Closer to the Heart (Expert Vocals) | 3:40 |
| 39. |  Pandora | 28,817 | Credits - Rock Band 2 | 36:54 |
| 40. | paulink | 28,734 | Monster - Rock Band 2 DLC FAIL | 3:37 |
| 41. | Eric F | 26,592 | Rock Band 2 - Basic Guitar Alt-Strumming Tutorial | 9:01 |
| 42. | PotatoHandle | 26,414 | Rock Band 2 - Everlong - Expert Drums - Gold Stars (1 Miss.) | 4:29 |
| 43. | UlisesC005 | 25,308 | Rock Band 2 DX (DLC): blink-182 - What's My Age Again (Vocals Expert FC) | 2:40 |
| 44. | Tokyo90 | 25,084 | Rock Band 2 - Afterlife | 6:18 |
| 45. |  tvgry | 23,689 | Rocksmith 2014 i gra na basie tvgry.pl | 21:09 |
| 46. | The0IdMan | 23,258 | Hungry Like the Wolf Expert ION drums Rock Band 2 | 4:38 |
| 47. | retropolis gaming | 21,202 | Rock Band 2 at our karaoke wedding party - | 4:58 |
| 48. | Auddy | 20,262 | Rock Band - No Excuses - Expert - Guitar - Sightread - 99% - Gold Stars - High Quality | 4:59 |
| 49. |  Astérion | 20,203 | [Défi pimenté] Rock Band 2 + Micro + Chamallows | 5:43 |
| 50. | GameNut321 | 19,882 | Blue Snowball Mic VS Rock Band 2 Mic - Quality test | 3:56 |
| 51. | ZRXP | 19,009 | [Rock Band 2] Touhou - Marisa Stole the Precious Thing Guitar Cover (Expert Guitar) | 4:30 |
| 52. | GHJay | 18,798 | Rock Band 2 DLC Psychosocial Expert Guitar (233,928) playing banger song on my 20th birthday | 4:55 |
| 53. | Dizko | 18,475 | The Eurogamer TV Show: Rock Band 2 vs. Guitar Hero 4 | 10:28 |
| 54. | LysiX | 18,419 | (WII) How to Install Custom Songs for Rock Band 2 Deluxe | 10:22 |
| 55. | ParallaxDG | 18,105 | Rock Band 2 - Shackler's Revenge 100% FC (Expert Guitar) | 3:57 |
| 56. | Der Lindwurm | 17,855 | Penelope McQueen Sings Still Alive from Portal | 3:09 |
| 57. | Cheese Curds 64 | 17,545 | Caprici Di Diablo - Rock Band 2 - Yngwie Malmsteen's Rising Force - Expert - Gold Star - PiP | 4:51 |
| 58. | JasonParadise | 17,380 | JasonParadise & UKOGmonkey VS. A Colony of Birchmen | 4:49 |
| 59. | KSerika | 16,734 | Rock Band 2 - Dirty Little Secret (Vocals, Expert) | 3:31 |
| 60. | TheDarkStation88 | 16,604 | New Reviews Tommy T Returns Pt 3 of 3 | 7:02 |
| 61. | YoshiFan007 | 16,283 | Rock Band 2 - Guitar and Drums - Expert - Sprode (Battle of the Bands) | 3:54 |
| 62. |  Gamesweasel | 16,140 | Rock Band 2 review | 2:49 |
| 63. |  PaiBiônico | 15,936 | Rock Band 2 - Carry on my wayward son - All solos 100% FC | 1:12 |
| 64. | GuitarHeroPhenom | 15,504 | E3 MTV Pepsi Rock Band 2 Contest + GHP Day 2 Part 2 | 10:01 |
| 65. | Grohlvana | 15,409 | 1,000 Subscribers! My Proudest Xbox 360 Achievement! | 6:20 |
| 66. |  Rawiioli | 14,556 | Rock Band 2 - Gewinnspiel - Siegerehrung | 5:55 |
| 67. | IGN | 14,106 | Rock Band 2 Nintendo Wii Gameplay - Drum Trainer Mode | 1:11 |
| 68. | WULFF DEN | 13,800 | Rock Band 2 (Xbox 360 2008) The best music game? - The Backlog | 10:30 |
| 69. | Carson Mauthe | 13,671 | Rock Band 2: The Hardest Song In The Game | 8:39 |
| 70. | Rymante | 13,615 | Rock Band 2 Expert Vocals - Livin on a Prayer (Gold Stars) | 5:05 |
| 71. | David G | 13,179 | Rock Band 2 - The Ultimate Showdown (RBN Mix) - Expert Drums Gold Stars | 5:11 |
| 72. | Derpferdler | 13,005 | 🌲🎵 The Trees (Vault Edition) | Rock Band 2! 🥁🎸 #Rush | 0:30 |
| 73. | MultiSt3p | 12,992 | Rock Band Track Pack Vol. 2 (Xbox360) Snow ((Hey Oh)) | 8:24 |
| 74. | llamaswillbemine | 11,584 | (360) ...And Justice for All - Rock Band 2 Expert Drums 98% | 10:08 |
| 75. | OMG KON! | 11,101 | Kon - Get Ready To Rokk 99% Gold Stars Drums (EXPERT) on Rock Band 2 DLC | 3:16 |
| 76. | Lightstream | 11,066 | RB3- The deceiver 1st ever guitar FC 400TH VIDEO!! (team KOX) | 6:18 |
| 77. | chunkatuff | 10,309 | Nyan Cat 100% FC | 3:43 |
| 78. | EmpireArcadia | 10,237 | Prod1gy X receives Guinness World Record in Rock Band 2 | 3:18 |
| 79. | HerofTime64 | 10,079 | Rock Band 2 Wii - Music Store DLC | 7:59 |
| 80. | Degness222 | 9,975 | Rock Band 2 Nintendo Guitar | 0:19 |
| 81. | skuldnoshinpu | 9,680 | Waiting For You - Rock Band 2 (360) Custom | 5:45 |
| 82. | FRONTmedienTV | 9,453 | Rock Band 3 Gameplay-Trailer Xbox 360 PS3 Wii | 4:01 |
| 83. | 한규환 | 9,291 | [720P HD] Rock Band 2 (RBN) - Cluster (RB2 Version) - Expert Guitar - 100% FC | 4:27 |
| 84. | AllenDRK | 9,174 | Weight Of The World - Jukebox Mode (Rock Band 2 DX) | 3:47 |
| 85. | Dawn Brown | 9,143 | Rock band 2 looking at the challenge setlist | 0:39 |
| 86. | André Roronora Zoro | 8,614 | Rock Band 2 - Make a Setlist [Expert Bass] | 15:11 |
| 87. |  EA Italia | 8,562 | Rock Band - Cinematic Video HD | 1:49 |
| 88. | Guitar Hero and rock band rocks | 8,391 | rock band 2 get clean 5 stars (101,229) | 4:06 |
| 89. | rfmckinleyport gameplays | 8,152 | Rock Band 2 - Kids in America by The Muffs (Expert) - 99% | 3:57 |
| 90. | ZacharyShow | 8,026 | Hey John, What's Your Name Again? - The Devil Wears Prada - Rock Band 2 Ex. Guitar & Vox | 3:40 |
| 91. | TamakoIsBae | 7,965 | Rock Band 2 "The Leaving Song Pt. 2" Vocals FC 211,640 | 3:53 |
| 92. |  WiiPR | 7,909 | Rock Band 2 Xbox 360 Trailer | 1:43 |
| 93. | joshscorcher | 7,701 | Awesome Video Game Intros 10: Rock Band Collection | 6:02 |
| 94. | Sabresfan81 | 7,611 | Rock Band 2-Anyway You Want It- Gold Stars EXPERT | 3:58 |
| 95. | Shane Roth | 7,421 | Rock Band 2 (Otis Redding-On The Dock Of The Bay) | 3:01 |
| 96. | Electronic Arts France | 6,987 | Rock Band 2 - trailer | 1:17 |
| 97. | NoDot | 6,770 | Rock Band 2 Expert Guitar Rush - Trees Solo FC | 0:49 |
| 98. | AshhBearr | 6,464 | Rock Band 2 - Still Alive - GLaDOS - Expert - 100% FC | 3:24 |
| 99. | freqrexy | 6,405 | Rock Band DLC - Tribute (Expert Vocals FC) | 4:37 |
| 100. | Team Aftermath | 6,325 | Crosses by Sleeping With Sirens ft. Spencer Chamberlain of UNDEROATH Full Band FC #5316 | 3:57 |
