| 1. |  OTG | 33,122 | [S3][P10] Serious Sam [HTSF] | 9:59 |
| 2. | JarfJam | 18,499 | Serious Sam Second Encounter Parse Error Dancing Croteam | 1:04 |
| 3. | GamingOnLinux | 5,325 | Serious Sam HD The Second Encounter - Fusion - Vulkan API | 2:46 |
| 4. | Video Game Kill Counts | 3,652 | Serious Sam HD: The Second Encounter (2010) Kill Count | 1:17:14 |
| 5. | Kikoskia | 3,301 | Let's Play Serious Sam HD The Second Encounter #44: The End... or is it? | 22:35 |
| 6. | HakureiDeity | 3,082 | Serious Sam Second Encounter Stage 1 Part 2 | 7:21 |
| 7. | RHG 45 | 2,755 | Serious Sam: The Second Encounter | PS4 Gameplay (Blind) | 26:58 |
| 8. | CZSurvivor | 2,326 | New Kingdom The Grand Obelisk Ep 15 VR Serious Sam The Second Encounter | 1:02:25 |
| 9. | Global Gaming | 1,680 | Serious Sam 2nd Encounter【ALL BOSSES】 | 18:25 |
| 10. | Plasma SKX | 1,211 | Serious Sam HD: The Secound Encounter - Legend of the Beast DLC - All Secrets | 7:20 |
| 11. | JustRed | 922 | Serious Sam 2 HD : Treasure Diving Steam Summer Camp Achievement | 0:33 |
| 12. | Yuri The Hentai | 839 | Serious Sam 3 Gachikazes Preview | 1:14 |
| 13. | GavGonaCRT | 837 | Serious Sam HD: The Second Encounter On A CRT Monitor (No Commentary) | 20:14 |
| 14. | George Cadman | 518 | 🔴LIVE MINI GUN MAIN 😎 FLAMETHROWER ENJOYER 😳 CERTIFIED ASS KICKER 🍑 | 6:36:21 |
| 15. | AbsinthTears Gaming | 446 | Serious Sam Collection - Launch Trailer - PS4 - Xbox One - Switch - PC | 1:50 |
| 16. | The Royal Guard | 384 | TheRoyalGuard | Serious Sam The Second Encounter HD | 1080p/60fps | Gameplay | 1:01:26 |
| 17. | Paradise Decay | 382 | Serious Sam: The Second Encounter VR | Oculus Rift | GeForce GTX 1060 (With Commentary) | 31:49 |
| 18. | DanteCrysis | 309 | Serious Confession - Serious Sam: The Second Encounter (W/ Tats TopVideos) - End | 24:18 |
| 19. | naughty venom | 201 | Serious Sam HD The Second Encounter | 22:26 |
| 20. | Cane and Rinse | 158 | Serious Sam HD: The Second Encounter Quick Rinse | 13:34 |
| 21. | JMonkey | 138 | Serious Sam: The Second Encounter Any% Tourist in 54:26.03! New PB | 57:03 |
| 22. | CPT_BADASS | 136 | Serious Sam The Second Encounter HD Episode 11 This Coridor Will Be The Death Of Me!!!!l | 1:02:38 |
| 23. | VODcore | 125 | Serious Sam - The Second Encounter HD Playthrough | 8:14:56 |
| 24. | akitta21 | 117 | Serious Sam: SE - Kleer Guy snapped | 0:46 |
| 25. | TenkoBerry | 101 | Serious Sam The Second Encounter HD (Ep:10): Finishing The Thing i Couldn't do in Childhood - RGRD's | 18:09 |
| 26. | SeriousTuber | 94 | 젠틀맨 근데 시리어스 샘이네 (Gentleman, but it’s Serious Sam) (AI Cover) | 0:19 |
| 27. | Roasty Bunz | 80 | Dahkness! (Serious Sam: The Second Encounter HD) | 8:08 |
| 28. | SilverStinger | 68 | Serious Sam HD: The Second Encounter - PC Gameplay - [1440p (2K), 60 FPS] - (FREE TO USE) | 16:47 |
| 29. | Piece of Pie Software | 64 | XMas Special 2020 - Serious Sam: The Second Encounter | 58:25 |
| 30. | Astrabee | 56 | Exploring Serious Sam's Alpha | 11:12 |
| 31. | RatchetGamingAllStars | 52 | Ps4 Serious Sam The Second Encounter Gameplay Playthrough | 5:10:00 |
| 32. | Cadeaux Man | 50 | World First LIVESIDE VS Milton Pike! (Hitless) | 2:03 |
| 33. | PDJ | 49 | Serious Sam - The Failed Encounter | 12:51 |
| 34. | ProjectMyst | 47 | The First 11 Minutes of Serious Sam HD: Legend of the Beast DLC Gameplay | Xbox One | 11:28 |
| 35. | EWA Gamesroom | 47 | Faz Plays - Serious Sam HD: The Second Encounter (Xbox 360)(Gameplay) | 21:34 |
| 36. | Soraioc | 45 | Serious Sam: The Second Encounter | 6:47:47 |
| 37. | Catsninetails | 42 | 17. Please Don't Hug Meeeeee Serious Sam The Second Encounter Part 2 [Twitch Archive] | 3:44:40 |
| 38. | Dread The Player | 39 | Palenque And The Crystal Skull! Serious Sam The Second Encounter Part 1 | 2:42:21 |
| 39. | ElectronicPleasure | 34 | AMD A10: ** Serious Sam - Second Encounter ** 5800K - 7870 | 20:18 |
| 40. | ItsMartyy_ | 26 | Serious Sam HD: The Second Encounter [Part 3] - Serious Co Op Playthrough | 17:45 |
| 41. | ZACH SPEIGHT | 25 | SERIOUS SAM COLLECTION DLC LEGEND OF THE BEAST PS4 | 17:39 |
| 42. | InfernalMonsoon | 25 | Serious Sam HD: The Second Encounter - Stream 2 FINAL | 4:24:56 |
| 43. | KindaKasual | 22 | Serious Sam: The Second Encounter | Twitch Highlights | 10:16 |
| 44. | AleK | 19 | Serious Sam SE Fusion Stair Bug | 3:39 |
| 45. | GreatScott TT | 13 | Serious Sam HD: The Second Encounter (PC) | 1:32 |
| 46. | SOVEREIGN4850 | 10 | Serious Sam Collection : The Second Encounter : Legend Of The Beast DLC / Gameplay : Part 2 | 48:55 |
| 47. | thedragonreaper | 9 | i'm being totally super serial right now with serious sam the 2nd encounter like seriously | 4:48:34 |
| 48. | lmcgregoruk | 2 | Serious Sam:The Second Encounter Completed | 5:52 |
