| 1. |  Gar | 136,772 | Serious Sam HD: The Second Encounter Legend of the Beast (Commentary) Part 4: Legendary Beast | 39:16 |
| 2. | kilplixism | 44,661 | Kilplix N Tate Play Serious Sam The 2nd Encounter #2 | 20:07 |
| 3. |  Valdis348 | 29,154 | Valdis vs. SpinatpiZZa (1.11) : Serious Sam: 2nd Encounter | 24:23 |
| 4. |  Wickman Wish | 28,103 | Let's Play Serious Sam HD: The Second Encounter [Co-op] - Part 16 | 26:43 |
| 5. | GuyNamedErick | 21,757 | Serious Sam: The Second Encounter - Serious Playthrough - All Secrets | 5:51:08 |
| 6. | flaschorLP | 15,298 | SERIOUS SAM HD: THE SECOND ENCOUNTER [07] - Serious Seriousness | Let's Play Together | 26:00 |
| 7. | Zarbach | 12,973 | Let's Play Serious Sam The Second Encounter HD | FINALE | Deutsch [Teil 50] | 15:37 |
| 8. | Juliean | 12,294 | Let's play Serious Sam Part 6 - der erste Goldjaguar | 9:46 |
| 9. | chk brk | 9,753 | Get Serious! Serious Sam The Second Encounter Part 4 | 5:35 |
| 10. | Meti Walkthroughs | 9,386 | Serious Sam The Second Encounter - SpeedLevel - Incomplete Playthrough | 10:22 |
| 11. |  Serious Sacor | 7,345 | Serious Sam: The Second Encounter Playthrough (Commentary) - Part 31 - The Grand Cathedral (4/4) | 17:51 |
| 12. |  KE1nonen | 5,568 | Serious Sam: The Second Encounter - Alpine Mists II: Dusts of Ages Part 2 (Serious) | 52:29 |
| 13. |  Loki D.S. | 5,154 | Serious Path - Alpha | 1:32 |
| 14. |  Serious Mkbewe | 4,343 | Serious Sam The Second Encounter - Alpha Reimagined and Future Enemy Resource Pack | 1:08:35 |
| 15. |  Natiunea Jucatoare | 4,200 | [RO] Let's Play Serious Sam the Second Encounter - Part 14 - ULTIMUL EPISOD | 29:47 |
| 16. |  NeoTyrant | 3,857 | Serious sam - Legend of the beast DLC coop playthrough part 5 | 18:12 |
| 17. | Trientia | 3,504 | Let's Play Serious Sam HD The Second Encounter Episode 4: Serious Courtyard | 18:11 |
| 18. |  Magicolo - Free Games | 2,955 | Serious Sam ALPHA Remake - Mod 2015 | 3:08 |
| 19. |  Freeman Bg - TV | 2,437 | Serious Sam on Ps Vita 😈 Serius Dungeons PSP Homebrew 🛠️ | 13:49 |
| 20. |  MPlayGaming | 2,327 | Serious Sam HD: The Second Encounter Playthrough The Grand Cathedral [4/5] 4K UHD | 7:57 |
| 21. | WhamNinjaMolehill | 2,152 | Live Stream: Serious Sam HD: The Second Encounter Blind Playthrough - Part 3 | 4:18:06 |
| 22. | GermansnakeGaming | 1,989 | Serious Sam HD The Second Encounter Deutsch (Coop) #001 - Serious Sam ist zurück! | 14:58 |
| 23. | Simpelicity | 1,813 | Let's play Serious Sam SE [29] Lift off | 27:16 |
| 24. | Arm4g3dd0nX | 1,597 | Let's Play: Serious Sam Second Encounter (P3) | 32:33 |
| 25. | FramePlay | 1,143 | Serious Sam 2000 Alpha Build | Unfinished Levels (ROUGH FOOTAGE) | 59:49 |
| 26. | Jareth Let ́s Play | 1,103 | Let's Play Serious Sam HD: TSE #021 [Deutsch] [UHD] - Ausgezaubert! [Finale] | 28:29 |
| 27. |  GameVersum | 1,067 | Serious Sam HD The Second Encounter Complete Gameplay PART 15 - The Lava Caves (2K 60FPS) | 33:43 |
| 28. | Andrea Rovenski | 864 | Serious Sam: The Second Encounter CO-OP Playthrough; Part 7 | 27:44 |
| 29. | WinXP_SP1 | 593 | ReactOS running Serious Sam Alpha and Half-Life | 6:04 |
| 30. | VampirchickenLP | 574 | Lets Play Together Serious Sam: Second Encounter (blind) #35 - Mordekai, der Beschwörer | 21:05 |
| 31. | EpixKev04 | 508 | DAS EPISCHE FINALE!!! (FINALE) | Serious Sam TSE Classic #20 | LetsPlayTogether SonKi84 + EpixKev04 | 27:08 |
| 32. | MissFortunaLP | 471 | Let's Play Serious Sam: The Second Encounter [feat. Sunfact & NoXxX] (Deutsch/German/Blind) #10 | 29:49 |
| 33. |  SuperSaiyanDragon | 432 | Serious Sam HD: The Second Encounter Episode XII Gameplay playthrough (No Commentary) The Cathedral | 57:12 |
| 34. | Stromsky | SkyCat | 423 | LPT Serious Sam 1 First Encounter #007 [Nikk] "The Ring" | 13:28 |
| 35. | Van FirleFranz | 393 | Serious Sam The Second Encounter # 26 noch mal alles drauf FINALE Let's Play German, Deutsch | 16:26 |
| 36. | Viktor Games | 285 | СВЯЩЕННЫЙ ДИСБАЛАНС | Serious Sam: Hell Encounter Impossible+++ | #3 | 1:16:46 |
| 37. | NecroManZer | 273 | Пара слов о Serious sam Alpha | 6:36 |
| 38. | 7 Different Kinds Of Smoke | 245 | Rus Lets Plays by M@x512 BLR : Уровень Бонус v 1 1 | 25:20 |
| 39. | KHGhost | 242 | Serious Sam's World War 3 (Ending) | Serious Sam The Second Encounter HD Blind Playthrough | PS5 | 1:47:04 |
| 40. | BIG TONY | 234 | Serious Sam The Second Encounter HD|60fps 1080p Ps4|Playthrough Part 12 | 59:11 |
| 41. | Ikarru | 226 | Let's Play Serious Sam Second Encounter Part 1 | 41:02 |
| 42. | AveBatTV | 226 | Serious Sam HD The Second Encounter coop part 13 Last Boss END | 2:56 |
| 43. |  TheMasters PS | 216 | Serious Sam SECOND Encounter HD COOP / Mr Meep | EP15 | 18:45 |
| 44. | Polignano a Meme | 210 | Polignano a Meme plays Serious Sam: The Second Encounter | 37:07 |
| 45. | CHAOS ROOKIE | 207 | Serious Sam (Xbox) Let's Play part 34 The final battle | 23:40 |
| 46. |  Gouludword | 178 | นับ 1-5 Playstation เรื่องราวของคอนโซลอันดับหนึ่ง / Playstation 2 | 0:58 |
| 47. |  LetsPlayOnePiece | 172 | Let's Play Serious Sam HD: The Second Encounter [Ende] #033 - Das legendäre Biest | 36:39 |
| 48. | DarkRaptor86 | 138 | Lets Play Together Serious Sam: The Second Encounter Classic Edition Folge 24 | 27:01 |
| 49. | Vault of console games | 125 | Serious Sam: The Second Encounter |4k60fps| Longplay (Xbox Original) | 6:12:15 |
| 50. | Rob Flynn (Wolverous) | 120 | Serious Sam: The Second Encounter | 5:00:41 |
| 51. | mkssa | 117 | Let's play! #1 Serious Sam: The Second Encounter (2-ая серия) | 26:55 |
| 52. | EON | 112 | Serious Sam (The First and Second Encounter) Maximum Speed & Fire Rate | Full Gameplay | part 6 | 38:49 |
| 53. | Sephiroth Let's Play | 99 | SERIOUS SAM HD: THE SECOND ENCOUNTER #08 - Into the Storm! - Let's Play Together | 18:36 |
| 54. |  Dr. Atecep | 98 | SERIOUS SAM HD: THE SECOND ENCOUNTER #5 | Playthrough PT-ENG | 2:00:30 |
| 55. | KING MORGAN | 89 | Tyrone plays Serious Sam the Second Encounter More Serious Levels | 1:15:02 |
| 56. | Snack Time Sports | 89 | Let's Play Serious Sam: The Second Encounter [Co-op] - Episode 10 (Finale) | 37:49 |
| 57. |  The Royal Guard | 80 | TheRoyalGuard | Serious Sam HD: The Second Encounter | Playthrough | 1080p 60fps | 59:00 |
| 58. | nixan | 76 | [let's play] Serious Sam (german) part 21 | 26:09 |
| 59. | SlyfoXlive | 74 | Let's Play Serious Sam The Second Encounter HD Co-op mit DickWanst & SlyfoX | 21.01.2017 | #15 | 50:28 |
| 60. | McPhisto2051 | 72 | #24 - Serious Sam - The Second Encounter (LP/1080p/60fps/ger) - The Grand Obelisk 2/2 | 24:25 |
| 61. | Jironobou | 55 | Let's Play Serious Sam ╘66═ Raining Hell | 18:47 |
| 62. | RatchetGamingAllStars | 52 | Ps4 Serious Sam The Second Encounter Gameplay Playthrough | 5:10:00 |
| 63. | EWA Gamesroom | 47 | Faz Plays - Serious Sam HD: The Second Encounter (Xbox 360)(Gameplay) | 21:34 |
| 64. | Muppio | 46 | Let's Play Serious Sam HD: The Second Encounter - 1 - Sierra de Chiappas | 27:02 |
| 65. | Neon Henchman | 39 | Serious Sam: LPR: Démente [17] Pyramide en bois | 30:15 |
| 66. |  TOMMYK Yt | 39 | CZ let's play Serious Sam The firts encounter #13 FINAL | 36:53 |
| 67. |  CloudCrafts | 36 | Serious Sam HD: The Second Encounter Playthrough (Part 2) Palenque - Sierra de Chiapas [1/3] | 14:15 |
| 68. | Serious Santa | 29 | Serious Sam: Alpha [Remake] | Прохождение | #2 | 22:00 |
| 69. | TeeZaah | 24 | Let's Play Serious Sam (TSE) Part 2 - SPIKY ROOM | 20:15 |
| 70. | Popular Geekery | 22 | The Popular Geekery crew plays Serious Sam TSE pt2 | 23:38 |
| 71. |  VISUAL NOVEL GATE | 14 | MARCH OF THE DEAD - Gameplay | 10:18 |
| 72. | GermanGamers2000 | 14 | [Single] Let's Play: Serious Sam: The Second Encounter HD PART 01 | 15:01 |
| 73. | Longplay Studio 313 | 9 | Serious Sam HD: The Second Encounter - Legend of the Beast Longplay (Playstation 4) | 2:37:46 |
| 74. | GunslingerSyayo | 7 | Let's Play & Finish Serious Sam 2nd Encounter Before SS4!! #7 | 21:28 |
| 75. | PS2freak11223 | 4 | Let's Play Serious Sam HD 2: Serious Sam and the Temple of the Crystal Indiana Jones Harpy | 17:18 |
| 76. | Cheddar Shadooby | 1 | Red faction PlayStation 4 | 34:31 |
