| 1. |  Jelly | My GIRLFRIEND Helps Me CHEAT In SLITHER.IO! | 7,194 | Let's Play |
| 2. | SquiddyPlays | SquiddyPlays - SLITHER.IO - Rage Quit! | 2,461 | Let's Play |
| 3. | Amy Lee (Amy Lee33) | Amy Lee Plays Slither.io! | WE GET ON THE LEADERBOARD! High Score! | Amy Lee33 | 1,201 | Let's Play |
| 4. | Vikkstar123 | BEST START EVER! - 30,000+ SIZE! - SLITHER.IO #2 with Vikkstar | 1,180 | Let's Play |
| 5. | SquiddyPlays | SquiddyPlays - WORM.IS - SO MUCH RAGE! | 898 | Let's Play |
| 6. | Amy Lee (Amy Lee33) | Amy Lee Plays Slither.io! | Meet Mr Wiggles! | Slither.io Lets Play | Amy Lee33 | 713 | Let's Play |
| 7. | Ricky And Zai | LICK MY FACE! | Slither.io | 616 | Let's Play |
| 8. | SB737 | SLITHERING INTO TROUBLE! | Slither.io | 584 | Let's Play |
| 9. | Amy Lee (Amy Lee33) | Slither.io TOP SCORE! WE ARE NUMBER ONE! | Slither.io Lets Play | Amy Lee33 | 508 | Let's Play |
| 10. | TSMC - Minecraft | Donald Trump Plays Slither.io? | 267 | Let's Play |
| 11. | SalemsLady M | SALEM PLAYS - SLITHER.IO! | 68 | Let's Play |
| 12. | tyler1 highlights | TYLER1 PLAYS SLITHER.IO + BATTLERITE [VOD: 4-10-2016] | 50 | Let's Play |
| 13. | EnglishSimmer | Slither.io: I'M NUMBER ONE!! | 45 | Let's Play |
| 14. | Star_Shine1 | Let's Play: Slither.io | 38 | Let's Play |
| 15. | SammiiCake Gaming | JUST DO IT! - Slither.io - Part 1 | 34 | Let's Play |
| 16. | SnakeDoctorChannel | Slither.io - SNAKE PLAYS SNAKE - Slither.io Online Game | 30 | Let's Play |
| 17. | Mamma MishaBe67 | Slither.io Lets play | 30 | Let's Play |
| 18. | KylePlays | THE NEXT BIG GAME!! | Opka.io | 25 | Let's Play |
| 19. | Mamma MishaBe67 | FROGAR.IO Lets Play | 22 | Let's Play |
| 20. | Mamma MishaBe67 | LET'S PLAY SLITHER.IO | 20 | Let's Play |
| 21. | SammiiCake Gaming | HAPPY SKIN! - Slither.io - Part 2 | 19 | Let's Play |
| 22. | tvbplays | WHY I STARTED YOUTUBE | YouTuber Tag | tvbplays 'n' vlogs | #1 | 17 | Let's Play |
| 23. | Solidarity | SLITHER.IO IN ROBLOX!? | Roblox Dragon Riders | With NettyPlays & Tomohawk | 16 | Let's Play |
| 24. | HenryTMC | Kid plays Slither.io gets Top of the Leaderboard | Epic Slither gameplay | 13 | Let's Play |
| 25. | Hexxic! | WATCH OUT FOR MAH SNEK (Slither.io) - One-Off - Hexxic Plays! | 10 | Let's Play |
| 26. | Matt and Gus | Gus Plays - Slither.io *Rage Returns!* | 9 | Let's Play |
| 27. | Mamma MishaBe67 | Lets Play Slither.io | 7 | Let's Play |
| 28. | Twelfth Consul | COME ON!!?? - Worm.is Lets Play AGRESSIVE FAIL GAMEPLAY EPSIDOE 2!! | 6 | Let's Play |
| 29. | L Plays | Slither.IO: MY FIRST TIME ON SLITHER.IO | 5 | Let's Play |
| 30. | Khazaboom | SNAKE? SNAAAAAAKE!! ► Slither.io #1 ►Let's Play/Gameplay/Funny Moments◄ | 4 | Let's Play |
| 31. | Avanta | Slither.io Solo Plays 1 | 4 | Let's Play |
| 32. | Sval Plays | Sval Plays... Slither.io | 4 | Let's Play |
| 33. | Khazaboom | SO MANY JACK SKINS!► Slither.io #2 ►Let's Play/Gameplay/Funny Moments◄ | 4 | Let's Play |
| 34. | Sval Plays | Sval Plays... Slither.io | 4 | Let's Play |
| 35. | tvbplays | MYSTIC SPACE SLUGS - Let's Play - Slither.io - #1 | 3 | Let's Play |
| 36. | RAD Gaming | Gulper.io | 3 | Let's Play |
| 37. | Sval Plays | Sval Plays... Slither.io! The Little Snke that (almost) Could! | 3 | Let's Play |
| 38. | No Formal Training | slitherio - Let's Play | 2 | Let's Play |
| 39. | Randomise User: The Best Indie Games | CLUSTERF*CK! Slither.io 50K score challenge | Let's play Slither.io gameplay | 2 | Let's Play |
| 40. | RAD Gaming | Gulper.io | 2 | Let's Play |
| 41. | Artemis | مارمو خوردن 🤣 gulper.io | 2 | Let's Play |
| 42. | THE THEATRE AND GAMING MECHANIC | SILTHER.IO - TTAGM - IOS - ANDROID - GAMEPLAY - LET'S PLAY | 2 | Let's Play |
| 43. | Twelfth Consul | Long Multicolored Thing??!! Worm.is Lets Play + Tutorial Gameplay Series Episode 1 | 2 | Let's Play |
| 44. | L Plays | Slither.IO: ULTIMATE KILL STEAL! | 1 | Let's Play |
| 45. | Sval Plays | Sval Plays... Slither.io - Again! | 1 | Let's Play |
