| 1. |  NintenU | 3,681,963 | Sonic & Knuckles All Bosses | 19:01 |
| 2. | TurkishBullet19 | 247,436 | Sonic & Knuckles [USA] (Sega Genesis) - (All Endings) | 17:11 |
| 3. | DanielGamerDX | 179,246 | Sky Sanctuary Zone, but it gets more Modern by every 50th Ring! | 7:39 |
| 4. | ZitaWup | 112,701 | Warframe - -96% Flight Speed Bullets. When You Are in Matrix | 3:52 |
| 5. | Ruki185 | 73,469 | Sonic Mania - Sonic & Knuckles Playthrough - Egg Reverie | True Ending | Credits | 11:03 |
| 6. | HeavyMetal Rocker1988 | 49,057 | SMW Custom Music - Track 1377 (Sonic & Knuckles - Lava Reef Zone (Act 1)) (Variety 2) | 2:13 |
| 7. | LETSPLAYmarkus | 26,495 | SONIC 3 & KNUCKLES A.I.R. # 12 🦔 Death Egg & The Doomsday Zone! | 19:49 |
| 8. | baLANDor Silber | 25,151 | SEGA und die List der Delistings | 0:00 |
| 9. | DerTolleIgel | 11,895 | Sonic & Knuckles [German/Sonic] #0012 - Boss-Kampf | 13:42 |
| 10. | Peppi the Dog ˆᴥˆ | 5,358 | Sonic & Knuckles - Game Over (GENESIS/MEGA DRIVE OST) | 0:09 |
| 11. | TechnoMichaSDL | 4,017 | TechnoMicha - Sonic & Knuckles Mini Boss Theme [Remix] SEGA MEGA DRIVE (GENESIS) 2012 | 1:49 |
| 12. | Vexan_Twitch | 2,141 | Sonic and Knuckles meme | 0:08 |
| 13. | GFrom Reviews | 2,110 | SONIC & KNUCKLES + LOCK-ON-TECHNOLOGY = MAGIC! (Review) | 42:37 |
| 14. | LETSPLAYmarkus Streams | 1,880 | 🔴 SONIC & KNUCKLES [RA] 🦔 + MARIO PARTY [RA] # 03 🎲 Twitch-Livestream # 350 vom 11.09.20 | 4:23:59 |
| 15. | ESound | 1,698 | Sonic & Knuckles Part 12 (PS3) | 8:41 |
| 16. | RetroJuli | 955 | SONIC & KNUCKLES 🦔 #9: Knuckles vs. Super Mecha Sonic | 21:01 |
| 17. | SEröGA Gaming | 729 | Sonic & Knuckles SEGA Mega Drive #sonicandknuckles #sega #retro #сега #ретро | 0:59 |
| 18. | BaghiraZero | 457 | Flying Battery Zone (Massive Air Fortress Remix) - Sonic & Knuckles / Sonic Mania | 0:00 |
| 19. | Princess Daisy Fun Paradise! :o) | 384 | Sky Sanctuary Zone | 1:19 |
| 20. | LadyYurikoLP | 372 | Sonic & Knuckles - Knuckles #04 ENDE (Sega Genesis/Mega Drive) [Let's Play/Deutsch] | 42:16 |
| 21. | Van_Shadow_ | 326 | Sonic 3 & Knuckles | The Doomsday Zone | #14 | Shadow zockt [Sega Genesis] [gameplay] | 13:24 |
| 22. | PeterTheMurder | 321 | Sonic and Knuckles.exe (The 250th EXE Games Episode Special) | 4:23 |
| 23. | AlbertWesker LP | 310 | Sonic & Knuckles - Death Egg Zone Finale (Retro Lets Play) [100% & voice sounds] | 38:44 |
| 24. | Nimputs | 248 | [WR] Sonic Adventure (DC) - Casinopolis Knuckles speedrun in 9.73 | 0:28 |
| 25. | VG OSTs | 230 | Sonic & Knuckles ~ Doomsday Zone ~ OST | 2:02 |
| 26. | Atomic Thrill Gaming | 211 | Sonic & Knuckles 🦔 Gameplay-Clip #shorts #megadrive #sega #sonicthehedgehog #sonic #retrogaming | 0:31 |
| 27. | Lord Gamer | 185 | Lets Play Sonic and Knuckles - Sonic 3 (German-Chaos Emeralds CHALLENGE Nr.2 Master Emerald-ENDE | 1:23:54 |
| 28. | Micha-Teddy93 | 130 | Sonic & Knuckles ☆ Videospielmusik ☆ Special Stage | 2:23 |
| 29. | XBlueTarouX | 93 | Sonic - Lava Reef Zone Remix ♪ | 2:41 |
| 30. | SpielSatzFail | 74 | Let's Play Sonic & Knuckles #6 - Death Egg Zone (Ende) | 46:17 |
| 31. | Achampnator | 72 | Lets Play sonicandknuckles.exe | 6:10 |
| 32. | BREDES | 42 | Sonic and Knuckles- all bosses - no damage - easy way to win #shorts #youtubeshorts #sonic | 13:14 |
| 33. | LaharlLP | 31 | Let's Play Sonic & Knuckles #004 Knuckles Weg | 12:32 |
| 34. | Levelmarvin | 23 | alle Chaos Emeralds in sonic & knuckles auf der Sega mega drive | 19:03 |
| 35. | LpStorm100 | 18 | 98% Let's Retro Game Sonic & Knuckles [Full-HD] | 14:17 |
| 36. | SiIberGewehr | 17 | Flying Battery Zone: Akt 1 - Sonic & Knuckles Collection Musik | 1:36 |
| 37. | PiuPiuPilo | 11 | LTest 13#//sonicandknuckles.exe//Ähh Ok...★ | 4:32 |
| 38. | LETSPLAYoli | 11 | LETS TEST # 10 SONIC & KNUCKLES | 9:56 |
| 39. | Tolle Letsplays | 9 | SEGA mega Drive Flashback - 12 - Sonic 1&2, Sonic & Knuckles, Sonic Spinball (deutsch) | 16:15 |
| 40. | CanalWillplay | 5 | Sonic e knuckles game play parte 2 | 53:58 |
| 41. | TerraChannel / TerraFox | 1 | Let's Play Sonic Speedfreshed (German) (Facecam) [QHD] | 4:23 |
| 42. | EgamersNetworkTV | #Shorts | 0 | EgamersNetworkTV | #twitchtvclips | #sonic #Gaming #sega #gaming #fun #funny #egamersnetworktv | 2:59 |
