| 2024-11-13 |  Holden's Sentence | 392 | SpaceChem | Holden's Impressions | 0:00 |
| 2023-10-03 | Izzy | 10 | SpaceChem A Brief History of SpaceChem 196, 1, 20 2023 10 02 10 48 49 | 0:12 |
| 2021-07-14 | HexTree | 528 | SpaceChem - Blind Let's Play - part 14 | 3:10:36 |
| 2020-09-14 | The Great Berate | 13,200 | SpaceChem Tournament 2020 - Round 9 - Scientific Rule 110 | 5:06:01 |
| 2020-08-03 | Holden Gatsby | 122 | Holden's Extreamvaganza: SpaceChem (03/08/2020) | 33:04 |
| 2020-07-02 | Table 53 | 3,490 | SpaceChem Review | 9:26 |
| 2019-07-16 | Binky | 211 | SpaceChem 2019 tournament round 1 solutions - Normalization | 22:00 |
| 2019-03-19 | Atridas | 23 | Atridas Plays SpaceChem | 0:46 |
| 2017-12-09 | Randomise User: The Best Indie Games | 54,400 | Best Ludum Dare 40 Games #6: Cats are Assholes, Micro Trooper, Amitosis, Super Cop Hero, Bonding Bad | 15:27 |
| 2017-04-25 | DDRJake | 83,800 | Punishment Game #065: SpaceChem | 1:50:39 |
| 2016-12-12 | LazyGameBros | 50 | SpaceChem -Motion Blind Lets Play 04 | 32:03 |
| 2016-06-29 | Alan Temaficoni | 101 | SpaceChem - Fabricating Ammonia ("It Takes Three") | 0:21 |
| 2015-11-29 | Azraels Gaming | 5,680 | spacechem level | 6:30 |
| 2015-03-24 | Chris Jarvis | 16 | SpaceChem - No Thanks Necessary (6989/3/138) | 0:55 |
| 2014-11-03 | Zac Field | 253 | Electric Box Walkthrough (Easy and Medium Badges) | 12:30 |
| 2014-07-08 | Rafael Budnik | 1,080 | SpaceChem - Crossover (254/1/20) | 0:13 |
| 2013-10-14 | Piece of Pie Software | 9,400 | GAME RAFFLE - SpaceChem | 5:39 |
| 2012-08-26 | TenBear | 97 | Let's Play SpaceChem | 6:37 |
| 2012-04-19 | Aavak | 236,000 | SpaceChem - Sleepless on Sernimir IV (983/2/27) | 0:11 |
| 2012-04-17 | RebelliousUno | 70 | SpaceChem - Falling (4009/5/132) | 0:53 |
| 2012-01-14 | The Eyles | 13 | SpaceChem - Accidents Happen (1495/1/40) | 1:16 |
| 2011-10-07 | Balasarius | 35 | A Look at SpaceChem by Zachtronics Industries | 12:22 |
| 2011-07-28 | ZeroGravitas | 19,100 | SpaceChem - Split Before Bonding (99/1/30) | 0:06 |
| 2011-07-06 | Jonster | 27 | SpaceChem - Nothing Works (1122/4/84) | 0:12 |
| 2011-07-01 | Gaming Pants | 46 | SpaceChem - Tunnels II (193/1/9) | 0:10 |
| 2011-06-15 | Dan200 | 1,320 | SpaceChem - Challenge: KOHCTPYKTOP (23091/5/212) | 2:37 |
| 2011-05-23 | AfroMorello | 30 | SpaceChem - Sleepless on Sernimir IV (830/2/42) | 0:10 |
| 2011-05-12 | Smokestorm | 239 | SpaceChem - Every Day is the First Day (373/1/42) | 0:19 |
| 2011-05-10 | Jademalo | 722 | SpaceChem - Sleepless on Sernimir IV (1298/2/50) | 0:12 |
| 2011-03-20 | Balthelion | 2,950 | SpaceChem - No Thanks Necessary (3188/4/138) | 0:38 |
| 2011-02-04 | Robin 64 | 135 | SpaceChem - A Brief History of SpaceChem | 0:09 |
