| 1. | Matthewmatosis | SpaceChem Review | 236 | Review |
| 2. |  Scott Manley | Spacechem - Chemistry, In Spaaaccce. | 187 | |
| 3. | Northernlion | Let's Look At - SpaceChem | 181 | |
| 4. | Matthewmatosis | Recommending SpaceChem | 164 | |
| 5. | GuavaMoment | SpaceChem - Intentionally Slow Solutions | 76 | |
| 6. | Tasselfoot | Electric Box Walkthrough - Candystand | 64 | Walkthrough |
| 7. |  azenet | Découverte de SpaceChem | 62 | |
| 8. | Arthur Huynh | SpaceChem - Polar Expedition Achievement Guide + Free TF2 items (Steam Gift Grab) | 60 | Guide |
| 9. | Impartial Spector | Spacechem - Working | 58 | |
| 10. |  umcarainteressante | Que Merda É Essa #6 - Spacechem | 57 | |
| 11. | Zachtronics | SpaceChem: An Introduction | 56 | |
| 12. | slowbeef | SpaceChem - User-Created Assignment (23/1/50) | 52 | |
| 13. | Szyl | how to get the spacechem items in TF2 2023 | 51 | |
| 14. | Derek Kisman | SpaceChem - Precursor Compounds (1 reactor!) | 49 | |
| 15. | spar13 | SpaceChem - Moustachium 608 (1198/1/59) | 33 | |
| 16. | UnChainedLP: Сергей Лав | SpaceChem - варим космический мет! | 31 | |
| 17. | Derek Kisman | SpaceChem - Gas Works Park (1 reactor!) | 31 | |
| 18. | GuavaMoment | SpaceChem - SLOWER Intentionally Slow Solutions | 31 | |
| 19. |  Strumienie z Ruczaju | WBW: SpaceChem | 30 | |
| 20. | GuavaMoment | SpaceChem - The 74th Rule of Acquisition | 29 | |
| 21. | Gaming With BenWo0 | Ben's 5K Sub-stravaganza Pizza Party! | 28 | |
| 22. | GuavaMoment | SpaceChem - Sandbox Recycler | 27 | |
| 23. | TenFeetDown | How to SpaceChem : Tutorial 1 | 27 | Tutorial |
| 24. | sprucemooseful | SpaceChem: One Reactor Solution for "No Ordinary Headache" | 26 | |
| 25. | Sgt.McRuff | SpaceChem In-Place Swap 1 reactor 941 cycles 32 symbols | 26 | |
| 26. | PaV | Five games you've never heard of | 25 | |
| 27. | skundaihoy | SpaceChem - Going Green | 23 | |
| 28. | michelcolman | SpaceChem - Molecular Foundry (44118/1/65) Single Waldo: Internals | 23 | |
| 29. | GuavaMoment | SpaceChem Tournament - Final Results | 20 | |
| 30. | thebluecommet | Space Chem nothing works on danopth | 20 | |
| 31. | LagMasterSam | SpaceChem - No Ordinary Headache (1140,1,49) | 19 | |
| 32. | JSano19 - Dr. Nurse, Fire Fighter, Gamer | SpaceChem - The Tutorial | 19 | |
| 33. | The Gemsbok | The Atmosphere of SpaceChem | 19 | |
| 34. | Haiaiai | SpaceChem Brainfuck Interpreter - Sandbox Contest Entry | 19 | |
| 35. | GuavaMoment | SpaceChem Tournament - Intro to SpaceChem | 19 | |
| 36. | skundaihoy | SpaceChem - Gas Works Park | 19 | |
| 37. | Cascade Fury | SpaceChem - Moustachium 608 (187/1/42) | 18 | |
| 38. | slowbeef | SpaceChem: The Toughest Puzzler | 18 | |
| 39. | MetalBear | Jogo Rápido: Spacechem - Gameplay Português Vamos Jogar PT-BR | 18 | |
| 40. |  Bear is Driving | SpaceChem - Random Oxides - 16 Symbols | 17 | |
| 41. | Haiaiai | SpaceChem - Exploding Head Syndrome | 17 | |
| 42. |  Table 53 | SpaceChem Review | 17 | Review |
| 43. | Impartial Spector | Spacechem - Under Construction | 16 | |
| 44. | Negative Root | Spacechem 1 Brain Pain | 16 | |
| 45. | HenryEx | No Ordinary Headache - 1 Reactor, NO SENSORS [SpaceChem] | 16 | |
| 46. | Ched Cheese | SpaceChem - A Most Unfortunate Malfunction - Danopth | 16 | |
| 47. | Negative Root | Spacechem 4 360 No Scope | 15 | |
| 48. | Etrigane | [Early Access] Big Pharma - Le Spacechem pharmaceutique | 15 | |
| 49. | elorfinthendt | SpaceChem No Thanks Necessary full playthrough | 15 | Let's Play |
| 50. | Negative Root | Spacechem 2 Hints Required | 15 | |
| 51. | Haiaiai | Spacechem KOHCTPYKTOP - 3 Reactors - 3433 Cycles | 15 | |
| 52. | spar13 | SpaceChem - Moustachium 602 (268/1/26) | 14 | |
| 53. | Zachtronics | SpaceChem, by Zachtronics Industries | 14 | |
| 54. | tojomojo62 | SpaceChem - Crossover (113089/1/138) | 14 | |
| 55. | Woitee | SpaceChem Challenge: Applied Fusion - 1 Reactor Solution | 14 | |
| 56. | Jurk0wski | SpaceChem - End of the Line - Automated, no input necessary | 13 | |
| 57. | Sahishar | SpaceChem - Accidents Happen (1044/1/24) - symbol optimized | 13 | |
| 58. | Alexander Zeillinger | SpaceChem - Moustachium 608 (228/1/41) | 13 | |
| 59. |  Galaksi Seyahatname | Spacechem Türkçe Oynanış - Temel Prensipler | 13 | |
| 60. | DFWanderingKid | SpaceChem Ep2 - Sernimir IV and additional game mechanics | 13 | |
| 61. | Dead Workers Party | The Daily Spencer 5/10/2011: SpaceChem! | 13 | |
| 62. | Ched Cheese | SpaceChem - No Need For Introductions - Alkonost | 13 | |
| 63. | Piece of Pie Software | GAME RAFFLE - SpaceChem | 12 | |
| 64. | Sobtanian | SpaceChem Challenge: In-Place Swap (1 reactor) | 12 | |
| 65. | thebluecommet | SpaceChem Nothing Works On Danopth in 422 Cycles | 12 | |
| 66. | DFWanderingKid | SpaceChem 9 - No Thanks Necessary | 12 | |
| 67. | DDRJake | Punishment Game #065: SpaceChem | 12 | |
| 68. | GuavaMoment | SpaceChem - PAX Challenge 1 | 12 | |
| 69. | PieceOfMindTheFirst | SpaceChem - "Exploding Head Syndrome" HANDS-FREE solution (3349/3/99) | 12 | |
| 70. | LoudTristero | SpaceChem - Don't Fear The Reaper | 12 | |
| 71. | UnChainedLP: Сергей Лав | InfiniFactory - Реинкарнация SpaceChem | 11 | |
| 72. | skundaihoy | SpaceChem - Σ-Ethylene | 11 | |
| 73. | plexci | Plexci's Weihnachtskalender 2013 - Best of Indie Games - Spacechem | 11 | |
| 74. | Celebrinu | SpaceChem - It Takes Three (116/1/22) | 11 | |
| 75. | GuavaMoment | SpaceChem Tournament - Week 7 Results | 10 | |
| 76. | GuavaMoment | SpaceChem Single Elimination Tournament Round One | 10 | |
| 77. | Sahishar | SpaceChem - Multiple Outputs (52/1/59) - cycle optimized (deprecated) | 10 | |
| 78. | cearnicus | SpaceChem - No Need for Introductions - 1 reactor | 10 | |
| 79. | Randomise User: The Best Indie Games | Best Ludum Dare 40 Games #6: Cats are Assholes, Micro Trooper, Amitosis, Super Cop Hero, Bonding Bad | 10 | |
| 80. | MrFoxterCZ | SpaceChem - Settling into the Routine - low cycles (831/3/64) | 10 | |
| 81. | Aavak | SpaceChem - Of Pancakes and Spaceships (128/1/7) | 10 | |
| 82. |  nsjb | SpaceChem - Don't Fear The Reaper (detailed) | 10 | |
| 83. | MauveButterfly | SpaceChem: Of Pancakes and Spaceships (Level 1-1) | 9 | |
| 84. | Anton Petrov | MineTest- review - GAMES IN EDUCATION (Math and more) | 9 | Review |
| 85. | GuavaMoment | SpaceChem Single Elimination Tournament - Round 3 | 9 | |
| 86. | Mhykol | SpaceChem - Of Pancakes and Spaceships (188/1/9) | 9 | |
| 87. | DFWanderingKid | SpaceChem Ep3 - Danopth's first 3 puzzles | 8 | |
| 88. | Cascade Fury | SpaceChem - Moustachium 602 (46/1/37) | 8 | |
| 89. | DFWanderingKid | SpaceChem 15 - Exploding Head Syndrome | 8 | |
| 90. | serbaldrig | SpaceChem - Settling into the Routine (821/3/37) Cycle Optimized | 8 | |
| 91. | Negative Root | Spacechem 3 Increasing Complexity | 8 | |
| 92. | slowbeef | SpaceChem: The Toughest Puzzler (Part 2) | 8 | |
| 93. | DFWanderingKid | SpaceChem 30 - End of the Line - The Final Board | 8 | |
| 94. | DFWanderingKid | SpaceChem 19 - Challenge: KOHCTPYKTOP | 8 | |
| 95. |  Lorzax | Spacechem | Ep. 01 | Rompiéndome la cabeza con la química | 8 | |
| 96. | SirChauncey1 | SpaceChem - End of the Line | 8 | |
| 97. | Fabio “Petrucio” Stange | SpaceChem - Every Day is the First Day (316/1/20) - Simple, Symmetrical | 8 | |
| 98. | GuavaMoment | SpaceChem Tournament - Week 8 Results | 8 | |
| 99. | Lusankya | SpaceChem Advanced: Waldo Stalling, Order of Operations (It Takes Three) | 8 | |
| 100. | mandokir | SpaceChem - Moustachium 604 (173/1/16) | 7 | |
