| 1. |  jacksepticeye | FRIENDS TILL THE END | Riddle Transfer 2 (Series Finale) | 18,714 | |
| 2. | jacksepticeye | The Binding of Isaac | SO MUCH MISERY | 2,478 | |
| 3. | Nogla & Lui Gaming | 0 HOURS PLAYED with 200 HOURS PLAYED! | Binding of Isaac Online! | 419 | |
| 4. | Nogla | Binding of Isaac co-op is the most toxic experience ever | 151 | |
| 5. | RockLeeSmile | Let's Play - Isaac WotL: LIVE! [Fresh Start] (Ep.1) (ft. Bisnap) | 89 | Let's Play |
| 6. | RockLeeSmile | Roundtable Live! - 2/12/2016 (Ep.31) [Isaac Is Child Abuse?] | 83 | Show |
| 7. | RockLeeSmile | Democracy of Isaac | 70 | |
| 8. | imWhiskerZ | This Little NEW Rogulike SLAPS | Binding of Isaac Gameplay | 50 | |
| 9. | The Lucky Roll | The Binding of Isaac: Four Souls - Card game - Review | 41 | Review |
| 10. | Niall Stenson | Sacrificial - The Binding Of Isaac Guitar Cover | 40 | |
| 11. | RockLeeSmile | Let's Play - Isaac WotL: LIVE! [Sequence Break?] (Ep.2) | 33 | Let's Play |
| 12. | Niall Stenson | Penance/Cellar Theme - The Binding Of Isaac Guitar Cover [60FPS] | 27 | |
| 13. | RockLeeSmile | Let's Play - The Binding of Isaac WotL (Ep.27) | 24 | Let's Play |
| 14. | RockLeeSmile | Northernlion Live Super Show [4/11/18] | 17 | |
| 15. | RockLeeSmile | Let's Play - The Binding of Isaac WotL (Ep.30) | 16 | Let's Play |
| 16. | RockLeeSmile | NLSS Funny Clips - Arena Song [8/6/14] | 14 | |
| 17. | RockLeeSmile | Let's Play - The Binding of Isaac WotL (Ep.15) | 14 | Let's Play |
| 18. | RockLeeSmile | NLSS Funny Clips - Fireworks [8/7/14] | 13 | |
| 19. | RockLeeSmile | Let's Play - The Binding of Isaac (Ep.1) | 13 | Let's Play |
| 20. | RockLeeSmile | Let's Play - The Binding of Isaac WotL (Ep.29) | 12 | Let's Play |
| 21. | RockLeeSmile | Let's Play - The Binding of Isaac WotL (Ep.37) | 11 | Let's Play |
| 22. | RockLeeSmile | Let's Play - The Binding of Isaac WotL (Ep.32) | 11 | Let's Play |
| 23. | RockLeeSmile | Let's Play - The Binding of Isaac WotL (Ep.26) | 11 | Let's Play |
| 24. | RockLeeSmile | Let's Play - The Binding of Isaac WotL (Ep.31) | 11 | Let's Play |
| 25. | RockLeeSmile | Let's Play - The Binding of Isaac WotL (Ep.35) | 10 | Let's Play |
| 26. | RockLeeSmile | Let's Play - The Binding of Isaac WotL (Ep.12) | 10 | Let's Play |
| 27. | RockLeeSmile | Let's Play - The Binding of Isaac WotL (Ep.28) | 9 | Let's Play |
| 28. | RockLeeSmile | Indie Impressions - The Binding of Isaac WotL | 9 | |
| 29. | RockLeeSmile | Let's Play - The Binding of Isaac WotL (Ep.21) | 9 | Let's Play |
| 30. | Majin Jamie | that was terrifying | 9 | |
| 31. | RockLeeSmile | Let's Play - The Binding of Isaac WotL (Ep.13) | 8 | Let's Play |
| 32. | RockLeeSmile | Let's Play - The Binding of Isaac WotL (Ep.34) | 8 | Let's Play |
| 33. | RockLeeSmile | Let's Play - The Binding of Isaac WotL (Ep.33) | 8 | Let's Play |
| 34. | RockLeeSmile | Let's Play - The Binding of Isaac WotL (Ep.25) | 8 | Let's Play |
| 35. | RockLeeSmile | Let's Play - The Binding of Isaac WotL (Ep.8) | 8 | Let's Play |
| 36. | RockLeeSmile | Let's Play - The Binding of Isaac WotL (Ep.23) | 7 | Let's Play |
| 37. | RockLeeSmile | Let's Play - The Binding of Isaac WotL (Ep.24) | 7 | Let's Play |
| 38. | RockLeeSmile | Let's Play - The Binding of Isaac WotL (Ep. 19) | 7 | Let's Play |
| 39. | RockLeeSmile | Let's Play - The Binding of Isaac WotL (Ep.9) | 7 | Let's Play |
| 40. | RockLeeSmile | Let's Play - The Binding of Isaac WotL (Ep.22) | 7 | Let's Play |
| 41. | RockLeeSmile | Let's Play - The Binding of Isaac WotL (Ep.17) | 6 | Let's Play |
| 42. | RockLeeSmile | Let's Play - Isaac WotL: LIVE! [Daily 7/19/14] (Ep.3) | 6 | Let's Play |
| 43. | RockLeeSmile | Let's Play - The Binding of Isaac WotL (Ep.16) | 5 | Let's Play |
| 44. | RockLeeSmile | Let's Play - The Binding of Isaac WotL (Ep.36) | 5 | Let's Play |
| 45. | RockLeeSmile | RockLeeSmile Live! - The Binding of Isaac Community Remix Mod | 5 | |
| 46. | RockLeeSmile | Let's Play - The Binding of Isaac (Ep.4) | 5 | |
| 47. | RockLeeSmile | Let's Play - The Binding of Isaac WotL (Ep.20) | 5 | Let's Play |
| 48. | RockLeeSmile | Let's Play - The Binding of Isaac WotL (Ep.10) | 5 | Let's Play |
| 49. | RockLeeSmile | Let's Play - The Binding of Isaac (Ep.5) | 4 | Let's Play |
| 50. | RockLeeSmile | True PC Gaming Cast - Episode 8 (With RockLeeSmile) | 4 | Show |
| 51. | RockLeeSmile | Let's Play - The Binding of Isaac WotL (Ep.14) | 4 | Let's Play |
| 52. | Scorpios9472 | THE BINDING OF ISAAC - WITH MIDNIGHTWOOOOOOOOOOOOOLVES !! | 3 | |
| 53. | RockLeeSmile | Let's Play - The Binding of Isaac (Ep.2) | 3 | Let's Play |
| 54. | RockLeeSmile | Let's Play - The Binding of Isaac WotL (Ep.6) | 3 | Let's Play |
| 55. | InsideAgameR | THIS IS YOUR LIFE NOW! : Is this my destiny in 5 mins! lets walk through my life together! | 3 | Walkthrough |
| 56. | Moth Girl Hina | Unlocking All Tarnished Characters [VTUBER] | 3 | Let's Play |
| 57. | Moth Girl Hina | Character Mod Showcase The Binding of Isaac | 2 | Show |
| 58. | RockLeeSmile | Let's Play - The Binding of Isaac (Ep.3) | 2 | Let's Play |
| 59. | RockLeeSmile | Let's Play - The Binding of Isaac WotL (Ep.7) | 2 | Let's Play |
| 60. | Ishmael | The binding of Isaac #1 | 2 | |
| 61. | RockLeeSmile | Let's Play - The Binding of Isaac WotL (Ep.18) | 2 | Let's Play |
| 62. | ForgottenGemExtras | The Binding Of Isaac AB+ #26 | 1 | |
| 63. | Ramba | [AFTERBIRTH] Azazel Greed Ep.2 | 1 | |
| 64. | Snodge_ | The Binding of Isaac - 1st Look - [1] | 1 | |
| 65. | TheChrisD | The Binding of Isaac - #1 | 1 | |
